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- W2171365156 abstract "<h3>AIM</h3> To determine if the diuretic spironolactone cross reacts with 17α-hydroxyprogesterone (17OHP) in an enzyme linked immunosorbent assay (ELISA) kit used for the mass screening of congenital adrenal hyperplasia. <h3>METHODS</h3> Concentrations of 17OHP on a blood filter paper disc were measured using an ELISA kit (kit C-7: ENZAPLATE N-17α -OHP-7; Chiron, Tokyo, Japan). The cross reactivity of spironolactone and its metabolites with 17OHP was determined. The concentrations of spironolactone and its metabolites in blood were measured using HPLC (high performance liquid chromatography). <h3>RESULTS</h3> Spironolactone cross reacted with 17OHP using kit C-7 (0.01%), by increasing 17OHP concentration in a dose dependent manner. The blood concentration of spironolactone and its metabolites was nearly 900 ng/ml, high enough to show an additive effect on the 17OHP concentration. About 12% of the false positive cases screened using the kit were due to the administration of spironolactone. <h3>CONCLUSIONS</h3> Spironolactone interferes with 17OHP concentrations, leading to false positive test results for CAH." @default.
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- W2171365156 date "1999-11-01" @default.
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- W2171365156 title "Influence of spironolactone on neonatal screening for congenital adrenal hyperplasia" @default.
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- W2171365156 doi "https://doi.org/10.1136/fn.81.3.f179" @default.
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