FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171371554> ?p ?o ?g. }

• W2171371554 endingPage "10966" @default.
• W2171371554 startingPage "10961" @default.
• W2171371554 abstract "The immunovariant N -ethyl- N -nitrosourea-induced mutations Pococurante (Poc) and Lackadaisical were found to alter MyD88, creating striking receptor-selective effects. Poc, in particular, prevented sensing of all MyD88-dependent Toll-like receptor (TLR) ligands except diacyl lipopeptides. Furthermore, Poc-site and classical BB loop mutations caused equivalent phenotypes when engrafted into any TLR/IL-1 receptor/resistance (TIR) domain. These observations, complemented by data from docking studies and site-directed mutagenesis, revealed that BB loops and Poc sites interact homotypically across the receptor:adapter signaling interface, whereas the C-terminal α E -helices support adapter:adapter and receptor:receptor oligomerization. We have thus defined the TIR domain surface that mediates association between TLRs and MyD88 and the surface required for MyD88 or TLR oligomerization. Moreover, MyD88 engages individual TLRs differently, suggesting the feasibility of selective pharmacologic TIR domain receptor blockade." @default.
• W2171371554 created "2016-06-24" @default.
• W2171371554 creator A5004810353 @default.
• W2171371554 creator A5010315360 @default.
• W2171371554 creator A5018827487 @default.
• W2171371554 creator A5024117387 @default.
• W2171371554 creator A5025976155 @default.
• W2171371554 creator A5031872815 @default.
• W2171371554 creator A5050590989 @default.
• W2171371554 creator A5051902385 @default.
• W2171371554 creator A5058956938 @default.
• W2171371554 creator A5059140393 @default.
• W2171371554 creator A5066956845 @default.
• W2171371554 creator A5078855521 @default.
• W2171371554 creator A5087563095 @default.
• W2171371554 date "2006-07-18" @default.
• W2171371554 modified "2023-09-26" @default.
• W2171371554 title "Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis" @default.
• W2171371554 cites W1519843522 @default.
• W2171371554 cites W1655860314 @default.
• W2171371554 cites W1966772446 @default.
• W2171371554 cites W1975459052 @default.
• W2171371554 cites W1979046104 @default.
• W2171371554 cites W1989656760 @default.
• W2171371554 cites W1996120614 @default.
• W2171371554 cites W2006404858 @default.
• W2171371554 cites W2013601771 @default.
• W2171371554 cites W2016928596 @default.
• W2171371554 cites W2019676172 @default.
• W2171371554 cites W2024741451 @default.
• W2171371554 cites W2039473156 @default.
• W2171371554 cites W2049874360 @default.
• W2171371554 cites W2065283382 @default.
• W2171371554 cites W2073938056 @default.
• W2171371554 cites W2082890018 @default.
• W2171371554 cites W2084832493 @default.
• W2171371554 cites W2089217951 @default.
• W2171371554 cites W2089575955 @default.
• W2171371554 cites W2106882534 @default.
• W2171371554 cites W2129319296 @default.
• W2171371554 cites W2139867627 @default.
• W2171371554 cites W2145584783 @default.
• W2171371554 cites W2147038697 @default.
• W2171371554 cites W2147903280 @default.
• W2171371554 cites W2156788946 @default.
• W2171371554 doi "https://doi.org/10.1073/pnas.0603804103" @default.
• W2171371554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1544157" @default.
• W2171371554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16832055" @default.
• W2171371554 hasPublicationYear "2006" @default.
• W2171371554 type Work @default.
• W2171371554 sameAs 2171371554 @default.
• W2171371554 citedByCount "119" @default.
• W2171371554 countsByYear W21713715542012 @default.
• W2171371554 countsByYear W21713715542013 @default.
• W2171371554 countsByYear W21713715542014 @default.
• W2171371554 countsByYear W21713715542015 @default.
• W2171371554 countsByYear W21713715542016 @default.
• W2171371554 countsByYear W21713715542017 @default.
• W2171371554 countsByYear W21713715542018 @default.
• W2171371554 countsByYear W21713715542019 @default.
• W2171371554 countsByYear W21713715542020 @default.
• W2171371554 countsByYear W21713715542021 @default.
• W2171371554 countsByYear W21713715542022 @default.
• W2171371554 countsByYear W21713715542023 @default.
• W2171371554 crossrefType "journal-article" @default.
• W2171371554 hasAuthorship W2171371554A5004810353 @default.
• W2171371554 hasAuthorship W2171371554A5010315360 @default.
• W2171371554 hasAuthorship W2171371554A5018827487 @default.
• W2171371554 hasAuthorship W2171371554A5024117387 @default.
• W2171371554 hasAuthorship W2171371554A5025976155 @default.
• W2171371554 hasAuthorship W2171371554A5031872815 @default.
• W2171371554 hasAuthorship W2171371554A5050590989 @default.
• W2171371554 hasAuthorship W2171371554A5051902385 @default.
• W2171371554 hasAuthorship W2171371554A5058956938 @default.
• W2171371554 hasAuthorship W2171371554A5059140393 @default.
• W2171371554 hasAuthorship W2171371554A5066956845 @default.
• W2171371554 hasAuthorship W2171371554A5078855521 @default.
• W2171371554 hasAuthorship W2171371554A5087563095 @default.
• W2171371554 hasBestOaLocation W21713715541 @default.
• W2171371554 hasConcept C103408237 @default.
• W2171371554 hasConcept C104317684 @default.
• W2171371554 hasConcept C119599485 @default.
• W2171371554 hasConcept C127413603 @default.
• W2171371554 hasConcept C136449434 @default.
• W2171371554 hasConcept C143065580 @default.
• W2171371554 hasConcept C159110408 @default.
• W2171371554 hasConcept C16318435 @default.
• W2171371554 hasConcept C170493617 @default.
• W2171371554 hasConcept C177284502 @default.
• W2171371554 hasConcept C183786373 @default.
• W2171371554 hasConcept C2776709828 @default.
• W2171371554 hasConcept C41685203 @default.
• W2171371554 hasConcept C501734568 @default.
• W2171371554 hasConcept C55493867 @default.
• W2171371554 hasConcept C71924100 @default.
• W2171371554 hasConcept C86803240 @default.
• W2171371554 hasConcept C95444343 @default.
• W2171371554 hasConceptScore W2171371554C103408237 @default.

• next