FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171377149> ?p ?o ?g. }

• W2171377149 endingPage "187" @default.
• W2171377149 startingPage "177" @default.
• W2171377149 abstract "The present study was undertaken to explore the antimalarial effect of a series of dicatecholate iron chelators. They may be made more or less lipophilic by increasing or reducing the length of the R substituent on the nitrogen. In vitro activity against the W2 and 3D7 clones of Plasmodium falciparum, toxicity on Vero cells and toxicity on uninfected erythrocytes by measure of the released haemoglobin were assessed for each compound. These findings were compared with the ability of iron(III), iron(II) and ferritin to reverse the inhibitory effect of catecholates. This study shows that increased lipid solubility of catecholate iron chelators does not lead to improved antimalarial activity. However, their activity is well correlated with their interaction with iron and with their toxicity against Vero cells. This study demonstrates a potent antimalarial effect of FR160 (R = C9H19) on five different strains of P. falciparumin vitro. FR160 inhibited parasite growth with an IC50 between 0.8 and 1.5 µM. The effects of FR160 on mammalian cells were minimal compared with those obtained with malaria parasites. FR160 acted on parasites at considerably higher rates than desferrioxamine, and at all stages of parasite growth. The drug was more effective at the late trophozoite and young schizont stages, although FR160 affected rings and schizonts as well. Ascorbic acid, a free radical scavenger, reduced the activities of FR160 and artesunate. FR160 might induce formation of free radicals, which could explain why FR160 antagonized the effects of artesunate and dihydroartemisinin." @default.
• W2171377149 created "2016-06-24" @default.
• W2171377149 creator A5078098543 @default.
• W2171377149 date "2002-08-01" @default.
• W2171377149 modified "2023-09-27" @default.
• W2171377149 title "Iron chelators as antimalarial agents: in vitro activity of dicatecholate against Plasmodium falciparum" @default.
• W2171377149 cites W1896395195 @default.
• W2171377149 cites W1957028641 @default.
• W2171377149 cites W1970058802 @default.
• W2171377149 cites W1974908027 @default.
• W2171377149 cites W1983699140 @default.
• W2171377149 cites W1991584531 @default.
• W2171377149 cites W1993465504 @default.
• W2171377149 cites W1999925819 @default.
• W2171377149 cites W2000188706 @default.
• W2171377149 cites W2007138719 @default.
• W2171377149 cites W2009258477 @default.
• W2171377149 cites W2009281834 @default.
• W2171377149 cites W2010818369 @default.
• W2171377149 cites W2011168394 @default.
• W2171377149 cites W2014419556 @default.
• W2171377149 cites W2015244174 @default.
• W2171377149 cites W2020251171 @default.
• W2171377149 cites W2021927807 @default.
• W2171377149 cites W2025765364 @default.
• W2171377149 cites W2039451198 @default.
• W2171377149 cites W2039654504 @default.
• W2171377149 cites W2040450077 @default.
• W2171377149 cites W2047069910 @default.
• W2171377149 cites W2051690168 @default.
• W2171377149 cites W205885959 @default.
• W2171377149 cites W2065314419 @default.
• W2171377149 cites W2074309033 @default.
• W2171377149 cites W2081059256 @default.
• W2171377149 cites W2088158705 @default.
• W2171377149 cites W2089288068 @default.
• W2171377149 cites W2090081368 @default.
• W2171377149 cites W2092991593 @default.
• W2171377149 cites W2106434216 @default.
• W2171377149 cites W2108672965 @default.
• W2171377149 cites W2112191861 @default.
• W2171377149 cites W2139878820 @default.
• W2171377149 cites W2145556489 @default.
• W2171377149 cites W2148450650 @default.
• W2171377149 cites W2157746760 @default.
• W2171377149 cites W2160301959 @default.
• W2171377149 cites W2165149490 @default.
• W2171377149 cites W2181657564 @default.
• W2171377149 cites W2284821231 @default.
• W2171377149 cites W2325256638 @default.
• W2171377149 cites W2395818450 @default.
• W2171377149 cites W2396251829 @default.
• W2171377149 cites W2404959663 @default.
• W2171377149 cites W2411574159 @default.
• W2171377149 cites W2412598121 @default.
• W2171377149 cites W2414753455 @default.
• W2171377149 cites W2418779688 @default.
• W2171377149 cites W2430876803 @default.
• W2171377149 cites W265490412 @default.
• W2171377149 cites W275765444 @default.
• W2171377149 cites W2469737944 @default.
• W2171377149 doi "https://doi.org/10.1093/jac/dkf104" @default.
• W2171377149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12161397" @default.
• W2171377149 hasPublicationYear "2002" @default.
• W2171377149 type Work @default.
• W2171377149 sameAs 2171377149 @default.
• W2171377149 citedByCount "48" @default.
• W2171377149 countsByYear W21713771492012 @default.
• W2171377149 countsByYear W21713771492013 @default.
• W2171377149 countsByYear W21713771492014 @default.
• W2171377149 countsByYear W21713771492016 @default.
• W2171377149 countsByYear W21713771492017 @default.
• W2171377149 countsByYear W21713771492019 @default.
• W2171377149 countsByYear W21713771492020 @default.
• W2171377149 countsByYear W21713771492021 @default.
• W2171377149 countsByYear W21713771492022 @default.
• W2171377149 countsByYear W21713771492023 @default.
• W2171377149 crossrefType "journal-article" @default.
• W2171377149 hasAuthorship W2171377149A5078098543 @default.
• W2171377149 hasBestOaLocation W21713771491 @default.
• W2171377149 hasConcept C178790620 @default.
• W2171377149 hasConcept C185592680 @default.
• W2171377149 hasConcept C202751555 @default.
• W2171377149 hasConcept C203014093 @default.
• W2171377149 hasConcept C2776028358 @default.
• W2171377149 hasConcept C2776120307 @default.
• W2171377149 hasConcept C2776672577 @default.
• W2171377149 hasConcept C2777752497 @default.
• W2171377149 hasConcept C2778048844 @default.
• W2171377149 hasConcept C2778059366 @default.
• W2171377149 hasConcept C2778118209 @default.
• W2171377149 hasConcept C2778319317 @default.
• W2171377149 hasConcept C2778371730 @default.
• W2171377149 hasConcept C2781160685 @default.
• W2171377149 hasConcept C29730261 @default.
• W2171377149 hasConcept C2986274086 @default.
• W2171377149 hasConcept C31903555 @default.
• W2171377149 hasConcept C55493867 @default.

• next