Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171394136> ?p ?o ?g. }
- W2171394136 endingPage "93" @default.
- W2171394136 startingPage "7084" @default.
- W2171394136 abstract "The control of cell growth is regulated through coordinated responses to growth factors and cell-extracellular matrix (ECM) interactions. Integrins, the major family of cell-ECM receptors, are vital to these coordinated responses. Although much is known of the role of integrins in growth promotion, specific examples of integrin-mediated cell growth inhibition are few. On the basis of our findings that the integrin beta8 subunit is expressed in airway epithelial cells and is absent in lung cancers, we investigated the role and mechanism of the integrin alphavbeta8 in mediating growth inhibition. When introduced into either a lung or colon carcinoma cell line, beta8 inhibited cell growth without inducing apoptosis. Ligation of alphavbeta8 also induced cell rounding, inhibited focal contact formation, and initiated an inhibitory signaling pathway as demonstrated by increased expression of the cyclin-dependent kinase inhibitor p21Cip1. The cytoplasmic domain of beta8 was capable of both growth inhibition and causing cell shape changes as shown by the use of a chimeric integrin construct consisting of the beta8-cytoplasmic domain coupled to the beta6-extracellular domain. Finally, when tested in vivo, beta8 potently inhibited tumor growth in nude mice. Together, these results implicate alphavbeta8 as a novel growth-regulatory molecule of epithelial cells." @default.
- W2171394136 created "2016-06-24" @default.
- W2171394136 creator A5036139824 @default.
- W2171394136 creator A5038017242 @default.
- W2171394136 creator A5041863997 @default.
- W2171394136 creator A5044483075 @default.
- W2171394136 creator A5056073315 @default.
- W2171394136 creator A5060770620 @default.
- W2171394136 creator A5067682920 @default.
- W2171394136 creator A5083852419 @default.
- W2171394136 date "2000-12-15" @default.
- W2171394136 modified "2023-09-26" @default.
- W2171394136 title "A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth." @default.
- W2171394136 cites W1480206373 @default.
- W2171394136 cites W1501970115 @default.
- W2171394136 cites W1506953782 @default.
- W2171394136 cites W1513264753 @default.
- W2171394136 cites W1524285426 @default.
- W2171394136 cites W1559679159 @default.
- W2171394136 cites W1561903693 @default.
- W2171394136 cites W1563326914 @default.
- W2171394136 cites W1565639679 @default.
- W2171394136 cites W1622543276 @default.
- W2171394136 cites W1634520049 @default.
- W2171394136 cites W1853993502 @default.
- W2171394136 cites W1876406510 @default.
- W2171394136 cites W1966748740 @default.
- W2171394136 cites W1967120404 @default.
- W2171394136 cites W1968509014 @default.
- W2171394136 cites W1971622089 @default.
- W2171394136 cites W1971653050 @default.
- W2171394136 cites W1973047647 @default.
- W2171394136 cites W1977093600 @default.
- W2171394136 cites W1977225005 @default.
- W2171394136 cites W1977426071 @default.
- W2171394136 cites W1991644963 @default.
- W2171394136 cites W1994651714 @default.
- W2171394136 cites W1999824658 @default.
- W2171394136 cites W2005644246 @default.
- W2171394136 cites W2006659499 @default.
- W2171394136 cites W2008732608 @default.
- W2171394136 cites W2010307195 @default.
- W2171394136 cites W2021124377 @default.
- W2171394136 cites W2023342066 @default.
- W2171394136 cites W2026162621 @default.
- W2171394136 cites W2026349049 @default.
- W2171394136 cites W2029231027 @default.
- W2171394136 cites W2035032863 @default.
- W2171394136 cites W2035641694 @default.
- W2171394136 cites W2038692329 @default.
- W2171394136 cites W2040251404 @default.
- W2171394136 cites W2041272659 @default.
- W2171394136 cites W2045393019 @default.
- W2171394136 cites W2045726722 @default.
- W2171394136 cites W2053582875 @default.
- W2171394136 cites W2058128032 @default.
- W2171394136 cites W2058376481 @default.
- W2171394136 cites W2058418451 @default.
- W2171394136 cites W2059035317 @default.
- W2171394136 cites W2060937867 @default.
- W2171394136 cites W2063753069 @default.
- W2171394136 cites W2064735316 @default.
- W2171394136 cites W2066279385 @default.
- W2171394136 cites W2067656705 @default.
- W2171394136 cites W2071323720 @default.
- W2171394136 cites W2081401313 @default.
- W2171394136 cites W2089218510 @default.
- W2171394136 cites W2095084280 @default.
- W2171394136 cites W2103737185 @default.
- W2171394136 cites W2108361166 @default.
- W2171394136 cites W2113267611 @default.
- W2171394136 cites W2120379841 @default.
- W2171394136 cites W2128884401 @default.
- W2171394136 cites W2130689737 @default.
- W2171394136 cites W2134571801 @default.
- W2171394136 cites W2137401341 @default.
- W2171394136 cites W2144243296 @default.
- W2171394136 cites W2144549532 @default.
- W2171394136 cites W2152930226 @default.
- W2171394136 cites W2154083290 @default.
- W2171394136 cites W2154169742 @default.
- W2171394136 cites W2162553740 @default.
- W2171394136 cites W2162589060 @default.
- W2171394136 cites W2171087525 @default.
- W2171394136 cites W2184089090 @default.
- W2171394136 cites W2216422662 @default.
- W2171394136 cites W2341726762 @default.
- W2171394136 cites W264187420 @default.
- W2171394136 cites W41965769 @default.
- W2171394136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11156415" @default.
- W2171394136 hasPublicationYear "2000" @default.
- W2171394136 type Work @default.
- W2171394136 sameAs 2171394136 @default.
- W2171394136 citedByCount "34" @default.
- W2171394136 countsByYear W21713941362012 @default.
- W2171394136 countsByYear W21713941362015 @default.
- W2171394136 countsByYear W21713941362017 @default.
- W2171394136 countsByYear W21713941362018 @default.