FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171397802> ?p ?o ?g. }

• W2171397802 endingPage "9259" @default.
• W2171397802 startingPage "9250" @default.
• W2171397802 abstract "Structure−activity correlations have been employed previously in the mechanistic interpretation of TTQ-dependent amine dehydrogenases using a series of para-substituted benzylamines. However, by combining the use of kinetic isotope effects (KIEs) and crystallographic analysis, in conjunction with structure−reactivity correlation studies, we show that para-substituted benzylamines are poor reactivity probes for TTQ-dependent aromatic amine dehydrogenase (AADH). Stopped-flow kinetic studies of the reductive half-reaction, with para-substituted benzylamines and their dideuterated counterparts, demonstrate that C−H or C−D bond breakage is not fully rate limiting (KIEs ∼ unity). Contrary to previous reports, Hammett plots exhibit a poor correlation of structure−reactivity data with electronic substituent effects for para-substituted benzylamines and phenylethylamines. Crystallographic studies of enzyme−substrate complexes reveal that the observed structure−reactivity correlations are not attributed to distinct binding modes for para-substituted benzylamines in the active site, although two binding sites for p-nitrobenzylamine are identified. We identify structural rearrangements, prior to the H-transfer step, which are likely to limit the rate of TTQ reduction by benzylamines. This work emphasizes (i) the need for caution when applying structure−activity correlations to enzyme-catalyzed reactions and (ii) the added benefit of using both isotope effects and structural analysis, in conjunction with structure−reactivity relationships, to study chemical steps in enzyme reaction cycles." @default.
• W2171397802 created "2016-06-24" @default.
• W2171397802 creator A5004792265 @default.
• W2171397802 creator A5040355941 @default.
• W2171397802 creator A5043216025 @default.
• W2171397802 creator A5048395558 @default.
• W2171397802 creator A5058612126 @default.
• W2171397802 creator A5069101665 @default.
• W2171397802 creator A5069667659 @default.
• W2171397802 date "2007-07-18" @default.
• W2171397802 modified "2023-09-29" @default.
• W2171397802 title "Isotope Effects Reveal That <i>Para</i>-Substituted Benzylamines Are Poor Reactivity Probes of the Quinoprotein Mechanism for Aromatic Amine Dehydrogenase^," @default.
• W2171397802 cites W1513416677 @default.
• W2171397802 cites W1539796472 @default.
• W2171397802 cites W1833956654 @default.
• W2171397802 cites W1968050567 @default.
• W2171397802 cites W1985624549 @default.
• W2171397802 cites W1989763284 @default.
• W2171397802 cites W1991133713 @default.
• W2171397802 cites W2025358509 @default.
• W2171397802 cites W2026239764 @default.
• W2171397802 cites W2028750260 @default.
• W2171397802 cites W2038840577 @default.
• W2171397802 cites W2051854967 @default.
• W2171397802 cites W2064590647 @default.
• W2171397802 cites W2071873843 @default.
• W2171397802 cites W2072153970 @default.
• W2171397802 cites W2079000200 @default.
• W2171397802 cites W2089319510 @default.
• W2171397802 cites W2094170863 @default.
• W2171397802 cites W2097310936 @default.
• W2171397802 cites W2099455158 @default.
• W2171397802 cites W2111378668 @default.
• W2171397802 cites W2121260810 @default.
• W2171397802 cites W2121890116 @default.
• W2171397802 cites W2150454959 @default.
• W2171397802 cites W2160790360 @default.
• W2171397802 cites W2829598496 @default.
• W2171397802 doi "https://doi.org/10.1021/bi7007239" @default.
• W2171397802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17636875" @default.
• W2171397802 hasPublicationYear "2007" @default.
• W2171397802 type Work @default.
• W2171397802 sameAs 2171397802 @default.
• W2171397802 citedByCount "4" @default.
• W2171397802 crossrefType "journal-article" @default.
• W2171397802 hasAuthorship W2171397802A5004792265 @default.
• W2171397802 hasAuthorship W2171397802A5040355941 @default.
• W2171397802 hasAuthorship W2171397802A5043216025 @default.
• W2171397802 hasAuthorship W2171397802A5048395558 @default.
• W2171397802 hasAuthorship W2171397802A5058612126 @default.
• W2171397802 hasAuthorship W2171397802A5069101665 @default.
• W2171397802 hasAuthorship W2171397802A5069667659 @default.
• W2171397802 hasConcept C121332964 @default.
• W2171397802 hasConcept C131779359 @default.
• W2171397802 hasConcept C142724271 @default.
• W2171397802 hasConcept C147597530 @default.
• W2171397802 hasConcept C178790620 @default.
• W2171397802 hasConcept C185592680 @default.
• W2171397802 hasConcept C204787440 @default.
• W2171397802 hasConcept C2776910235 @default.
• W2171397802 hasConcept C2778689049 @default.
• W2171397802 hasConcept C58364064 @default.
• W2171397802 hasConcept C62520636 @default.
• W2171397802 hasConcept C69928629 @default.
• W2171397802 hasConcept C71240020 @default.
• W2171397802 hasConcept C71924100 @default.
• W2171397802 hasConceptScore W2171397802C121332964 @default.
• W2171397802 hasConceptScore W2171397802C131779359 @default.
• W2171397802 hasConceptScore W2171397802C142724271 @default.
• W2171397802 hasConceptScore W2171397802C147597530 @default.
• W2171397802 hasConceptScore W2171397802C178790620 @default.
• W2171397802 hasConceptScore W2171397802C185592680 @default.
• W2171397802 hasConceptScore W2171397802C204787440 @default.
• W2171397802 hasConceptScore W2171397802C2776910235 @default.
• W2171397802 hasConceptScore W2171397802C2778689049 @default.
• W2171397802 hasConceptScore W2171397802C58364064 @default.
• W2171397802 hasConceptScore W2171397802C62520636 @default.
• W2171397802 hasConceptScore W2171397802C69928629 @default.
• W2171397802 hasConceptScore W2171397802C71240020 @default.
• W2171397802 hasConceptScore W2171397802C71924100 @default.
• W2171397802 hasIssue "32" @default.
• W2171397802 hasLocation W21713978021 @default.
• W2171397802 hasLocation W21713978022 @default.
• W2171397802 hasOpenAccess W2171397802 @default.
• W2171397802 hasPrimaryLocation W21713978021 @default.
• W2171397802 hasRelatedWork W1968876324 @default.
• W2171397802 hasRelatedWork W1977047664 @default.
• W2171397802 hasRelatedWork W1991794925 @default.
• W2171397802 hasRelatedWork W2002724865 @default.
• W2171397802 hasRelatedWork W2008211245 @default.
• W2171397802 hasRelatedWork W2024520218 @default.
• W2171397802 hasRelatedWork W2035716858 @default.
• W2171397802 hasRelatedWork W2145284050 @default.
• W2171397802 hasRelatedWork W2953261074 @default.
• W2171397802 hasRelatedWork W3191782969 @default.
• W2171397802 hasVolume "46" @default.
• W2171397802 isParatext "false" @default.
• W2171397802 isRetracted "false" @default.

• next