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• W2171397906 startingPage "33" @default.
• W2171397906 abstract "The solid dispersions with poloxamer 188 (P188) and solid solutions with polyvinylpyrrolidone K30 (PVPK30) were evaluated and compared in an effort to improve aqueous solubility and bioavailability of a model hydrophobic drug. All preparations were characterized by differential scanning calorimetry, powder X-ray diffraction, intrinsic dissolution rates, and contact angle measurements. Accelerated stability studies also were conducted to determine the effects of aging on the stability of various formulations. The selected solid dispersion and solid solution formulations were further evaluated in beagle dogs for in vivo testing. Solid dispersions were characterized to show that the drug retains its crystallinity and forms a two-phase system. Solid solutions were characterized to be an amorphous monophasic system with transition of crystalline drug to amorphous state. The evaluation of the intrinsic dissolution rates of various preparations indicated that the solid solutions have higher initial dissolution rates compared with solid dispersions. However, after storage at accelerated conditions, the dissolution rates of solid solutions were lower due to partial reversion to crystalline form. The drug in solid dispersion showed better bioavailability in comparison to solid solution. Therefore, considering physical stability and in vivo study results, the solid dispersion was the most suitable choice to improve dissolution rates and hence the bioavailability of the poorly water soluble drug." @default.
• W2171397906 created "2016-06-24" @default.
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• W2171397906 date "2007-01-01" @default.
• W2171397906 modified "2023-09-26" @default.
• W2171397906 title "Improving the Dissolution Rate of Poorly Water Soluble Drug by Solid Dispersion and Solid Solution—Pros and Cons" @default.
• W2171397906 cites W1968667721 @default.
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• W2171397906 doi "https://doi.org/10.1080/10717540600640278" @default.
• W2171397906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17107929" @default.
• W2171397906 hasPublicationYear "2007" @default.
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