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• W2171407076 endingPage "e0132136" @default.
• W2171407076 startingPage "e0132136" @default.
• W2171407076 abstract "Di-(2-ethylhexyl)phtalate (DEHP) is a plasticizer with endocrine disrupting properties found ubiquitously in the environment and altering reproduction in rodents. Here we investigated the impact of prenatal exposure to DEHP on spermatogenesis and DNA sperm methylation in two distinct, selected, and sequenced mice strains. FVB/N and C57BL/6J mice were orally exposed to 300 mg/kg/day of DEHP from gestation day 9 to 19. Prenatal DEHP exposure significantly decreased spermatogenesis in C57BL/6J (fold-change = 0.6, p-value = 8.7*10-4), but not in FVB/N (fold-change = 1, p-value = 0.9). The number of differentially methylated regions (DMRs) by DEHP-exposure across the entire genome showed increased hyper- and decreased hypo-methylation in C57BL/6J compared to FVB/N. At the promoter level, three important subsets of genes were massively affected. Promoters of vomeronasal and olfactory receptors coding genes globally followed the same trend, more pronounced in the C57BL/6J strain, of being hyper-methylated in DEHP related conditions. In contrast, a large set of micro-RNAs were hypo-methylated, with a trend more pronounced in the FVB/N strain. We additionally analyze both the presence of functional genetic variations within genes that were associated with the detected DMRs and that could be involved in spermatogenesis, and DMRs related with the DEHP exposure that affected both strains in an opposite manner. The major finding in this study indicates that prenatal exposure to DEHP can decrease spermatogenesis in a strain-dependent manner and affects sperm DNA methylation in promoters of large sets of genes putatively involved in both sperm chemotaxis and post-transcriptional regulatory mechanisms." @default.
• W2171407076 created "2016-06-24" @default.
• W2171407076 creator A5007301113 @default.
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• W2171407076 date "2015-08-05" @default.
• W2171407076 modified "2023-10-18" @default.
• W2171407076 title "Prenatal Exposure to DEHP Affects Spermatogenesis and Sperm DNA Methylation in a Strain-Dependent Manner" @default.
• W2171407076 cites W1575812631 @default.
• W2171407076 cites W1855288583 @default.
• W2171407076 cites W1965224994 @default.
• W2171407076 cites W1967333368 @default.
• W2171407076 cites W1968179768 @default.
• W2171407076 cites W1970052023 @default.
• W2171407076 cites W1976906208 @default.
• W2171407076 cites W1982171656 @default.
• W2171407076 cites W1985178609 @default.
• W2171407076 cites W1986024745 @default.
• W2171407076 cites W1987053416 @default.
• W2171407076 cites W1987557775 @default.
• W2171407076 cites W1993866744 @default.
• W2171407076 cites W1994048261 @default.
• W2171407076 cites W1998569297 @default.
• W2171407076 cites W2001051749 @default.
• W2171407076 cites W2002918346 @default.
• W2171407076 cites W2005501593 @default.
• W2171407076 cites W2008370344 @default.
• W2171407076 cites W2012802064 @default.
• W2171407076 cites W2013846360 @default.
• W2171407076 cites W2015353463 @default.
• W2171407076 cites W2015402753 @default.
• W2171407076 cites W2016171982 @default.
• W2171407076 cites W2018249152 @default.
• W2171407076 cites W2020541351 @default.
• W2171407076 cites W2021780354 @default.
• W2171407076 cites W2023158177 @default.
• W2171407076 cites W2026559515 @default.
• W2171407076 cites W2034470409 @default.
• W2171407076 cites W2036743604 @default.
• W2171407076 cites W2038622658 @default.
• W2171407076 cites W2043293981 @default.
• W2171407076 cites W2043673800 @default.
• W2171407076 cites W2045148798 @default.
• W2171407076 cites W2047458612 @default.
• W2171407076 cites W2048867062 @default.
• W2171407076 cites W2049153989 @default.
• W2171407076 cites W2052473671 @default.
• W2171407076 cites W2052710582 @default.
• W2171407076 cites W2054776840 @default.
• W2171407076 cites W2055344766 @default.
• W2171407076 cites W2055464151 @default.
• W2171407076 cites W2058759573 @default.
• W2171407076 cites W2065260973 @default.
• W2171407076 cites W2072271141 @default.
• W2171407076 cites W2075009571 @default.
• W2171407076 cites W2076203191 @default.
• W2171407076 cites W2078583788 @default.
• W2171407076 cites W2078872477 @default.
• W2171407076 cites W2084110570 @default.
• W2171407076 cites W2086744446 @default.
• W2171407076 cites W2089288112 @default.
• W2171407076 cites W2090401135 @default.
• W2171407076 cites W2092122739 @default.
• W2171407076 cites W2095514406 @default.
• W2171407076 cites W2096196036 @default.
• W2171407076 cites W2101037833 @default.
• W2171407076 cites W2103017472 @default.
• W2171407076 cites W2103041850 @default.
• W2171407076 cites W2107449283 @default.
• W2171407076 cites W2109145159 @default.
• W2171407076 cites W2111893619 @default.
• W2171407076 cites W2114104545 @default.
• W2171407076 cites W2118813981 @default.
• W2171407076 cites W2121818828 @default.
• W2171407076 cites W2122488988 @default.
• W2171407076 cites W2124584349 @default.
• W2171407076 cites W2124985265 @default.
• W2171407076 cites W2133058137 @default.
• W2171407076 cites W2135505974 @default.
• W2171407076 cites W2140291328 @default.
• W2171407076 cites W2141829495 @default.
• W2171407076 cites W2142601658 @default.
• W2171407076 cites W2149962584 @default.
• W2171407076 cites W2152378246 @default.
• W2171407076 cites W2157936339 @default.
• W2171407076 cites W2158698794 @default.
• W2171407076 cites W2160515768 @default.
• W2171407076 cites W2160697532 @default.
• W2171407076 cites W2348079883 @default.
• W2171407076 cites W2380598276 @default.
• W2171407076 cites W2412019321 @default.
• W2171407076 cites W2413793601 @default.
• W2171407076 doi "https://doi.org/10.1371/journal.pone.0132136" @default.
• W2171407076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4526524" @default.
• W2171407076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26244509" @default.

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