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- W2171415760 abstract "Abstract Adult hematopoiesis depends on rare multipotent hematopoietic stem cells (HSCs) that self-renew and give rise to progenitor cells, which differentiate to all blood lineages. The strict regulation of the fine balance between self-renewal and differentiation is essential for normal hematopoiesis and suppression of leukemia development. HSCs and progenitor cells are commonly assumed to reside within the hypoxic BM microenvironment, however, there is no direct evidence supporting this notion. Nevertheless, HSCs and progenitors do exhibit a hypoxic profile and strongly express Hif-1α. Although hypoxia signaling pathways are thought to play important roles in adult HSC maintenance and leukemogenesis, the precise function of Hif-dependent signaling in HSCs remains to be uncovered. Here we discuss recent gain-of-function and loss-of-function studies that shed light on the complex roles of hypoxia-signaling pathways in HSCs and their niches in normal and malignant hematopoiesis. Importantly, we comment on the current and often contrasting interpretations of the role of Hif-dependent signaling in stem cell functions. Stem Cells 2014;32:1390–1397" @default.
- W2171415760 created "2016-06-24" @default.
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- W2171415760 date "2014-05-23" @default.
- W2171415760 modified "2023-10-11" @default.
- W2171415760 title "Concise Review: Genetic Dissection of Hypoxia Signaling Pathways in Normal and Leukemic Stem Cells" @default.
- W2171415760 cites W1749022239 @default.
- W2171415760 cites W1965338602 @default.
- W2171415760 cites W1969734439 @default.
- W2171415760 cites W1970109552 @default.
- W2171415760 cites W1974182237 @default.
- W2171415760 cites W1974549729 @default.
- W2171415760 cites W1976747229 @default.
- W2171415760 cites W1982071626 @default.
- W2171415760 cites W1982401508 @default.
- W2171415760 cites W1982521119 @default.
- W2171415760 cites W1984352312 @default.
- W2171415760 cites W1985458442 @default.
- W2171415760 cites W1988377666 @default.
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- W2171415760 cites W1991219645 @default.
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- W2171415760 cites W1997422780 @default.
- W2171415760 cites W1999178985 @default.
- W2171415760 cites W2002777789 @default.
- W2171415760 cites W2005718040 @default.
- W2171415760 cites W2007984185 @default.
- W2171415760 cites W2012056552 @default.
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- W2171415760 cites W2030334534 @default.
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- W2171415760 doi "https://doi.org/10.1002/stem.1657" @default.
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