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• W2171440520 abstract "Background The molecular mechanisms of exercise training induced cardiovascular protection are poorly understood. There is growing evidence that reactive oxygen species may be involved in a number of these adaptations and that antioxidants may be used to investigate this effect. Objective To determine the effects of exercise training and/or antioxidant supplementation on myocardial endothelium and vascular endothelium gene expression. Methods Male Wistar rats were divided into four groups: i) control; ii) exercise trained (90 min of treadmill running 4d per week, 14 weeks); iii) antioxidant-supplemented (α-tocopherol 1000 IU kg−1 diet and α-lipoic acid 1.6 gkg−1 diet, mixed with rat chow) and iv) exercise trained and antioxidant-supplemented. Results cDNA microarray analysis showed diverse expression changes in both left ventricular and coronary artery endothelial cells. In particular, RT-PCR analysis showed that a gene involved in cardiovascular disease progression, Ras homolog gene family member A, was down-regulated by exercise, and up-regulated by antioxidant supplementation in left ventricular endothelial cells. Furthermore, an important gene involved in inflammation, IL-6, was down-regulated by all treatments. Conclusions Exercise training and/or antioxidant supplementation affects cardiac endothelial cell gene expression, and their effects on genes such as ras homolog gene family member A and IL-6 provides insight into the molecular mechanisms of their influences on cardiovascular diseases." @default.
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• W2171440520 date "2012-06-01" @default.
• W2171440520 modified "2023-09-23" @default.
• W2171440520 title "Effects of exercise and antioxidant supplementation on endothelial gene expression" @default.
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• W2171440520 doi "https://doi.org/10.1016/j.ijcard.2010.12.104" @default.
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