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- W2171447013 abstract "Ovarian cancer usually remains clinically silent until it is far advanced, and is associated with significant morbidity and mortality. In view of the modest impact of adjuvant treatments on survival, much effort is devoted to early detection programs and prevention strategies. However, the usefulness of early detection programs remains to be established, with only one randomized study indicating improved median survival in screened individuals. At present, oral contraceptives and prophylactic oophorectomy are the only options for prevention of ovarian cancer. Indications for prophylactic oophorectomy either as a primary procedure, or secondary to abdominal surgery, will vary according to the estimated risk, and to the individual's perception of that risk. Genetic screening allows better identification of pre-symptomatic individuals who would benefit the most from prophylactic oophorectomy. Data concerning the benefit of prophylactic surgery, and the safety of established or innovative hormone replacement therapies in individuals at risk, are encouraging." @default.
- W2171447013 created "2016-06-24" @default.
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- W2171447013 date "2000-01-01" @default.
- W2171447013 modified "2023-09-24" @default.
- W2171447013 title "Prophylactic oophorectomy: Clinical considerations" @default.
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- W2171447013 doi "https://doi.org/10.1002/1098-2388(200007/08)19:1<20::aid-ssu4>3.0.co;2-2" @default.
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