FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171451570> ?p ?o ?g. }

• W2171451570 endingPage "177" @default.
• W2171451570 startingPage "169" @default.
• W2171451570 abstract "The histopathological features of rheumatoid joint-inflammation suggest that an antigen-driven activation of T cells plays a central role in the onset and/or perpetuation of the inflammatory process. However, the disease-associated antigens responsible for the activation of T cells in the joint are unknown. In this project we study the response of IL-2 expanded T-cell lines from the synovial fluid (SF) of rheumatoid arthritis (RA) patients against autologous SF in a proliferation assay. Sixteen out of 32 RA patients were found to have CD4+ T cells that proliferate in response to autologous SF. The presence of T cells able to respond to SF antigens in inflamed joints suggests that these T cells play an active role in the pathogenesis of RA. T cell clones reactive to autologous SF were isolated from SF-derived T-cell lines of two RA patients. All clones were of the CD4+, CD8−-, α/β+ phenotype. SF-reactivity of T-cell clones from the DR4DR12-positive RA patient was restricted via the Dw4 subtype of DR4. SF reactivity of T cells of the DR12/DR15 patient was DP-restricted. Some of the T-cell clones responded specifically to autologous and not to allogeneic SF, whereas others revealed responsiveness against a limited number of allogeneic SF samples. The (restricted) specificity of T cells towards autologous SF antigens is indicative for heterogeneity of the epitopes recognized and argues against ubiquitous nonpolymorphic joint constituents as the relevant antigens recognized by the SF-autoreactive T cells." @default.
• W2171451570 created "2016-06-24" @default.
• W2171451570 creator A5021474476 @default.
• W2171451570 creator A5027656668 @default.
• W2171451570 creator A5039918302 @default.
• W2171451570 creator A5044269827 @default.
• W2171451570 creator A5052424289 @default.
• W2171451570 creator A5062474212 @default.
• W2171451570 creator A5063123142 @default.
• W2171451570 creator A5068769338 @default.
• W2171451570 creator A5078867438 @default.
• W2171451570 date "1995-01-01" @default.
• W2171451570 modified "2023-09-26" @default.
• W2171451570 title "Joint-Derived T Cells in Rheumatoid Arthritis Proliferate to Antigens Present in Autologous Synovial Fluid" @default.
• W2171451570 cites W1966588987 @default.
• W2171451570 cites W1974865963 @default.
• W2171451570 cites W1982917969 @default.
• W2171451570 cites W1993733461 @default.
• W2171451570 cites W2006088305 @default.
• W2171451570 cites W2015865604 @default.
• W2171451570 cites W2016096642 @default.
• W2171451570 cites W2016562027 @default.
• W2171451570 cites W2023691634 @default.
• W2171451570 cites W2034165703 @default.
• W2171451570 cites W2056280580 @default.
• W2171451570 cites W2058572069 @default.
• W2171451570 cites W2069997305 @default.
• W2171451570 cites W2076375577 @default.
• W2171451570 cites W2079184949 @default.
• W2171451570 cites W2084001516 @default.
• W2171451570 cites W2117322160 @default.
• W2171451570 cites W2133692536 @default.
• W2171451570 cites W2134753241 @default.
• W2171451570 doi "https://doi.org/10.3109/03009749509100922" @default.
• W2171451570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7747121" @default.
• W2171451570 hasPublicationYear "1995" @default.
• W2171451570 type Work @default.
• W2171451570 sameAs 2171451570 @default.
• W2171451570 citedByCount "13" @default.
• W2171451570 countsByYear W21714515702014 @default.
• W2171451570 countsByYear W21714515702016 @default.
• W2171451570 crossrefType "journal-article" @default.
• W2171451570 hasAuthorship W2171451570A5021474476 @default.
• W2171451570 hasAuthorship W2171451570A5027656668 @default.
• W2171451570 hasAuthorship W2171451570A5039918302 @default.
• W2171451570 hasAuthorship W2171451570A5044269827 @default.
• W2171451570 hasAuthorship W2171451570A5052424289 @default.
• W2171451570 hasAuthorship W2171451570A5062474212 @default.
• W2171451570 hasAuthorship W2171451570A5063123142 @default.
• W2171451570 hasAuthorship W2171451570A5068769338 @default.
• W2171451570 hasAuthorship W2171451570A5078867438 @default.
• W2171451570 hasConcept C142724271 @default.
• W2171451570 hasConcept C147483822 @default.
• W2171451570 hasConcept C154317977 @default.
• W2171451570 hasConcept C167672396 @default.
• W2171451570 hasConcept C195616568 @default.
• W2171451570 hasConcept C202751555 @default.
• W2171451570 hasConcept C203014093 @default.
• W2171451570 hasConcept C204787440 @default.
• W2171451570 hasConcept C2776090121 @default.
• W2171451570 hasConcept C2776164576 @default.
• W2171451570 hasConcept C2776268809 @default.
• W2171451570 hasConcept C2777077863 @default.
• W2171451570 hasConcept C2777575956 @default.
• W2171451570 hasConcept C2777652487 @default.
• W2171451570 hasConcept C2780942790 @default.
• W2171451570 hasConcept C55493867 @default.
• W2171451570 hasConcept C71924100 @default.
• W2171451570 hasConcept C86803240 @default.
• W2171451570 hasConcept C8891405 @default.
• W2171451570 hasConceptScore W2171451570C142724271 @default.
• W2171451570 hasConceptScore W2171451570C147483822 @default.
• W2171451570 hasConceptScore W2171451570C154317977 @default.
• W2171451570 hasConceptScore W2171451570C167672396 @default.
• W2171451570 hasConceptScore W2171451570C195616568 @default.
• W2171451570 hasConceptScore W2171451570C202751555 @default.
• W2171451570 hasConceptScore W2171451570C203014093 @default.
• W2171451570 hasConceptScore W2171451570C204787440 @default.
• W2171451570 hasConceptScore W2171451570C2776090121 @default.
• W2171451570 hasConceptScore W2171451570C2776164576 @default.
• W2171451570 hasConceptScore W2171451570C2776268809 @default.
• W2171451570 hasConceptScore W2171451570C2777077863 @default.
• W2171451570 hasConceptScore W2171451570C2777575956 @default.
• W2171451570 hasConceptScore W2171451570C2777652487 @default.
• W2171451570 hasConceptScore W2171451570C2780942790 @default.
• W2171451570 hasConceptScore W2171451570C55493867 @default.
• W2171451570 hasConceptScore W2171451570C71924100 @default.
• W2171451570 hasConceptScore W2171451570C86803240 @default.
• W2171451570 hasConceptScore W2171451570C8891405 @default.
• W2171451570 hasIssue "sup101" @default.
• W2171451570 hasLocation W21714515701 @default.
• W2171451570 hasLocation W21714515702 @default.
• W2171451570 hasOpenAccess W2171451570 @default.
• W2171451570 hasPrimaryLocation W21714515701 @default.
• W2171451570 hasRelatedWork W1991393819 @default.
• W2171451570 hasRelatedWork W2016719252 @default.
• W2171451570 hasRelatedWork W2068097628 @default.
• W2171451570 hasRelatedWork W2094585998 @default.

• next