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• W2171454878 endingPage "30" @default.
• W2171454878 startingPage "1" @default.
• W2171454878 abstract "In this Update, the cytogenetic and molecular genetic findings in osteosarcoma (OS) and some related tumors published since our book appeared in 1994 [1] will be presented and reviewed. Osteosarcoma is uncommon (i.e., 2.4% of all childhood cancers), with ∼1000 new cases diagnosed yearly in the United States. It is, however, the most common nonhematologic malignant tumor of bone in children (56% of all malignant tumors of bone) and adults [2]. The peak incidence of OS occurs in the second decade (5.6 per million children under 15 years of age), with an additional smaller peak after age 50 [3]. The tumors typically arise in the metaphyseal regions of long bones, with the distal femur, proximal tibia, and proximal humerus representing the three most common sites [4]. Almost all OS are of high grade and have a poor prognosis [5], with 10%–20% having detectable metastases at diagnosis. Only ∼10% of patients with OS achieve longterm disease-free interval [6–8]. The conventional OS type, arising in the intramedullary cavity of bone, represents ∼75% of all OS. These tumors frequently penetrate and destroy the cortex of the bone and extend into the surrounding soft tissues. The unifying histologic feature present in all types and subtypes of OS is the presence of malignant osteoid produced by the neoplastic cells [9]. Certain genetic or acquired conditions increase the risk of OS (e.g., metallic orthopedic prostheses and ionizing radiation) [10,11]. Patients with hereditary retinoblastoma have a high risk of second cancers, 50% of which are OS [12]. Osteosarcoma can arise in patients with Paget disease of bone, enchondromatosis, hereditary multiple exostoses, and fibrous dysplasia [13]." @default.
• W2171454878 created "2016-06-24" @default.
• W2171454878 creator A5027642211 @default.
• W2171454878 creator A5057299622 @default.
• W2171454878 date "2003-08-01" @default.
• W2171454878 modified "2023-10-09" @default.
• W2171454878 title "Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: osteosarcoma and related tumors" @default.
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