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- W2171463896 abstract "Interleukin 6 (IL-6) is a pleiotropic cytokine with a pivotal role in the pathophysiology of rheumatoid arthritis (RA). It is found in abundance in the synovial fluid and serum of patients with RA and the level correlates with the disease activity and joint destruction. IL-6 can promote synovitis and joint destruction by stimulating neutrophil migration, osteoclast maturation and vascular endothelial growth factor (VEGF)-stimulated pannus proliferation. IL-6 may also be mediating many of the systematic manifestations of RA including inducing the acute-phase reaction [including C-reactive protein (CRP)], anaemia through hecipidin production, fatigue via the hypothalmic-pituitary-adrenal (HPA) axis) and osteoporosis from its effect on osteoclasts. In addition, IL-6 may contribute to the induction and maintenance of the autoimmune process through B-cell maturation and TH-17 differentiation. All of the above makes IL-6 blockade a desirable therapeutic option in the treatment of RA. Following successful animal studies, a humanized anti-interleukin-6 receptor (anti-IL-6R) monoclonal antibody, tocilizumab (TCZ), entered into clinical trials and it has been shown to be an effective treatment in several large phase III clinical trials in RA with rapid and sustained improvement in disease activity, reducing radiographic joint damage and improving physical function." @default.
- W2171463896 created "2016-06-24" @default.
- W2171463896 creator A5063795404 @default.
- W2171463896 creator A5083583562 @default.
- W2171463896 date "2010-08-24" @default.
- W2171463896 modified "2023-10-11" @default.
- W2171463896 title "The role of Interleukin 6 in the pathophysiology of rheumatoid arthritis" @default.
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- W2171463896 cites W1880833927 @default.
- W2171463896 cites W1965756011 @default.
- W2171463896 cites W1971639265 @default.
- W2171463896 cites W1974457163 @default.
- W2171463896 cites W1976077702 @default.
- W2171463896 cites W1978172024 @default.
- W2171463896 cites W1982172588 @default.
- W2171463896 cites W1985589632 @default.
- W2171463896 cites W1985953874 @default.
- W2171463896 cites W1988318286 @default.
- W2171463896 cites W1990868699 @default.
- W2171463896 cites W1992613188 @default.
- W2171463896 cites W1993484882 @default.
- W2171463896 cites W1994339834 @default.
- W2171463896 cites W1995755401 @default.
- W2171463896 cites W1999855516 @default.
- W2171463896 cites W2000846863 @default.
- W2171463896 cites W2005536703 @default.
- W2171463896 cites W2005832407 @default.
- W2171463896 cites W2006708761 @default.
- W2171463896 cites W2012680181 @default.
- W2171463896 cites W2012942026 @default.
- W2171463896 cites W2015527055 @default.
- W2171463896 cites W2022713850 @default.
- W2171463896 cites W2025217427 @default.
- W2171463896 cites W2034976876 @default.
- W2171463896 cites W2036452124 @default.
- W2171463896 cites W2041184642 @default.
- W2171463896 cites W2043863730 @default.
- W2171463896 cites W2044561904 @default.
- W2171463896 cites W2047015493 @default.
- W2171463896 cites W2049414733 @default.
- W2171463896 cites W2055114626 @default.
- W2171463896 cites W2055928479 @default.
- W2171463896 cites W2060267166 @default.
- W2171463896 cites W2063216829 @default.
- W2171463896 cites W2063485775 @default.
- W2171463896 cites W2064998333 @default.
- W2171463896 cites W2067504868 @default.
- W2171463896 cites W2077688443 @default.
- W2171463896 cites W2081451656 @default.
- W2171463896 cites W2084102864 @default.
- W2171463896 cites W2088672818 @default.
- W2171463896 cites W2091169302 @default.
- W2171463896 cites W2095165075 @default.
- W2171463896 cites W2101596544 @default.
- W2171463896 cites W2108145145 @default.
- W2171463896 cites W2109506750 @default.
- W2171463896 cites W2110604741 @default.
- W2171463896 cites W2110901553 @default.
- W2171463896 cites W2111091679 @default.
- W2171463896 cites W2114308202 @default.
- W2171463896 cites W2118640511 @default.
- W2171463896 cites W2125212735 @default.
- W2171463896 cites W2127692829 @default.
- W2171463896 cites W2134461080 @default.
- W2171463896 cites W2139339400 @default.
- W2171463896 cites W2139476329 @default.
- W2171463896 cites W2150952126 @default.
- W2171463896 cites W2155702314 @default.
- W2171463896 cites W2157234417 @default.
- W2171463896 cites W2159705610 @default.
- W2171463896 cites W2164481110 @default.
- W2171463896 cites W2166223856 @default.
- W2171463896 cites W2168822788 @default.
- W2171463896 cites W2170924625 @default.
- W2171463896 cites W2320349682 @default.
- W2171463896 cites W2340325420 @default.
- W2171463896 cites W2406295010 @default.
- W2171463896 cites W4249150518 @default.
- W2171463896 doi "https://doi.org/10.1177/1759720x10378372" @default.
- W2171463896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3383508" @default.
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