Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171464982> ?p ?o ?g. }
- W2171464982 endingPage "400" @default.
- W2171464982 startingPage "393" @default.
- W2171464982 abstract "Background: Patients with cystic fibrosis (CF) frequently experience pulmonary exacerbations that may lead to a faster subsequent decline in pulmonary function; however, this relationship has not been clearly established. The purpose of this study was to determine the association between the frequency of pulmonary exacerbations and subsequent forced expiratory volume in 1 sec (FEV1) decline in adults and children with CF. Methods: Cohort study of subjects followed in the Cystic Fibrosis Foundation Patient Registry from 2003 through 2006. Mixed effects modeling was used to estimate differences in rates of decline in FEV1 in 2004–2006 for patients with 0, 1, 2, or 3+ pulmonary exacerbation(s) in 2003. Results: Of 8,490 subjects who met inclusion criteria, 60% had 0 exacerbations, 23% had 1, 10% had 2, and 7% had 3+ exacerbations in 2003. Compared to children with no pulmonary exacerbations in 2003, children with one or more exacerbations experienced a significantly (P < 0.001) greater rate of FEV1 decline in 2004–2006. In contrast, among adults, only those with 3+ exacerbations in 2003 had a significantly (P = 0.01) greater rate of FEV1 decline in 2004–2006 than those with no exacerbations in 2003. Conclusions: There is a strong association between the frequency of pulmonary exacerbations and subsequent decline in pulmonary function. In adults, having 3+ exacerbations, and among children, having any exacerbations is associated with a greater rate of decline in the ensuing 3 years. Improved prevention, identification, and treatment of pulmonary exacerbations are likely to have long-term benefits for patients with CF, especially children. Pediatr Pulmonol. 2011; 46:393–400. © 2010 Wiley-Liss, Inc." @default.
- W2171464982 created "2016-06-24" @default.
- W2171464982 creator A5003565749 @default.
- W2171464982 creator A5003873304 @default.
- W2171464982 creator A5032042043 @default.
- W2171464982 creator A5078050470 @default.
- W2171464982 creator A5090179470 @default.
- W2171464982 date "2010-10-21" @default.
- W2171464982 modified "2023-10-03" @default.
- W2171464982 title "Pulmonary exacerbations are associated with subsequent FEV<sub>1</sub> decline in both adults and children with cystic fibrosis" @default.
- W2171464982 cites W1715680901 @default.
- W2171464982 cites W1904652721 @default.
- W2171464982 cites W1971558827 @default.
- W2171464982 cites W1979451256 @default.
- W2171464982 cites W1990336663 @default.
- W2171464982 cites W1996804057 @default.
- W2171464982 cites W2004189684 @default.
- W2171464982 cites W2032815975 @default.
- W2171464982 cites W2036216154 @default.
- W2171464982 cites W2048091641 @default.
- W2171464982 cites W2053471558 @default.
- W2171464982 cites W2061822958 @default.
- W2171464982 cites W2061909665 @default.
- W2171464982 cites W2074235114 @default.
- W2171464982 cites W2079477694 @default.
- W2171464982 cites W2082031673 @default.
- W2171464982 cites W2082832292 @default.
- W2171464982 cites W2098507554 @default.
- W2171464982 cites W2101273248 @default.
- W2171464982 cites W2105534700 @default.
- W2171464982 cites W2108678383 @default.
- W2171464982 cites W2109939030 @default.
- W2171464982 cites W2142418276 @default.
- W2171464982 cites W2142443730 @default.
- W2171464982 cites W2142554222 @default.
- W2171464982 cites W2144947606 @default.
- W2171464982 cites W2153102800 @default.
- W2171464982 cites W2171230591 @default.
- W2171464982 doi "https://doi.org/10.1002/ppul.21374" @default.
- W2171464982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20967845" @default.
- W2171464982 hasPublicationYear "2010" @default.
- W2171464982 type Work @default.
- W2171464982 sameAs 2171464982 @default.
- W2171464982 citedByCount "212" @default.
- W2171464982 countsByYear W21714649822012 @default.
- W2171464982 countsByYear W21714649822013 @default.
- W2171464982 countsByYear W21714649822014 @default.
- W2171464982 countsByYear W21714649822015 @default.
- W2171464982 countsByYear W21714649822016 @default.
- W2171464982 countsByYear W21714649822017 @default.
- W2171464982 countsByYear W21714649822018 @default.
- W2171464982 countsByYear W21714649822019 @default.
- W2171464982 countsByYear W21714649822020 @default.
- W2171464982 countsByYear W21714649822021 @default.
- W2171464982 countsByYear W21714649822022 @default.
- W2171464982 countsByYear W21714649822023 @default.
- W2171464982 crossrefType "journal-article" @default.
- W2171464982 hasAuthorship W2171464982A5003565749 @default.
- W2171464982 hasAuthorship W2171464982A5003873304 @default.
- W2171464982 hasAuthorship W2171464982A5032042043 @default.
- W2171464982 hasAuthorship W2171464982A5078050470 @default.
- W2171464982 hasAuthorship W2171464982A5090179470 @default.
- W2171464982 hasConcept C126322002 @default.
- W2171464982 hasConcept C165637977 @default.
- W2171464982 hasConcept C187212893 @default.
- W2171464982 hasConcept C2776178081 @default.
- W2171464982 hasConcept C2776938444 @default.
- W2171464982 hasConcept C2777014857 @default.
- W2171464982 hasConcept C2777714996 @default.
- W2171464982 hasConcept C3018587741 @default.
- W2171464982 hasConcept C55520419 @default.
- W2171464982 hasConcept C71924100 @default.
- W2171464982 hasConcept C72563966 @default.
- W2171464982 hasConcept C75603125 @default.
- W2171464982 hasConceptScore W2171464982C126322002 @default.
- W2171464982 hasConceptScore W2171464982C165637977 @default.
- W2171464982 hasConceptScore W2171464982C187212893 @default.
- W2171464982 hasConceptScore W2171464982C2776178081 @default.
- W2171464982 hasConceptScore W2171464982C2776938444 @default.
- W2171464982 hasConceptScore W2171464982C2777014857 @default.
- W2171464982 hasConceptScore W2171464982C2777714996 @default.
- W2171464982 hasConceptScore W2171464982C3018587741 @default.
- W2171464982 hasConceptScore W2171464982C55520419 @default.
- W2171464982 hasConceptScore W2171464982C71924100 @default.
- W2171464982 hasConceptScore W2171464982C72563966 @default.
- W2171464982 hasConceptScore W2171464982C75603125 @default.
- W2171464982 hasIssue "4" @default.
- W2171464982 hasLocation W21714649821 @default.
- W2171464982 hasLocation W21714649822 @default.
- W2171464982 hasOpenAccess W2171464982 @default.
- W2171464982 hasPrimaryLocation W21714649821 @default.
- W2171464982 hasRelatedWork W1857123111 @default.
- W2171464982 hasRelatedWork W2005806130 @default.
- W2171464982 hasRelatedWork W2009245754 @default.
- W2171464982 hasRelatedWork W2031286892 @default.
- W2171464982 hasRelatedWork W2105611117 @default.
- W2171464982 hasRelatedWork W2130947272 @default.
- W2171464982 hasRelatedWork W2142443730 @default.