FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171485000> ?p ?o ?g. }

• W2171485000 endingPage "548" @default.
• W2171485000 startingPage "542" @default.
• W2171485000 abstract "Local cytokine production is a pathogenic factor in ischemia-reperfusion injury in early graft dysfunction. This study analyzed interleukin 8 (IL-8) messenger RNA (mRNA) expression in lung tissue and the association between IL-8 mRNA levels and interstitial lung changes in an experimental model of warm lung ischemia-reperfusion. We studied 16 New Zealand rabbits divided into 3 groups: control, ischemia (tissue taken from right lower lobe after 1, 2, or 3 hours of ischemia), and reperfusion (tissue taken from right upper and middle lobes after 1 hour of ischemia and 1, 2, or 3 hours of reperfusion). Expression of IL-8 mRNA was determined by reverse transcription and polymerase chain reaction. Interstitial infiltration by polymorphonuclear neutrophils was determined. The Mann-Whitney U-test was used for statistical comparisons, with P<.05 considered to indicate a significant result. During ischemia, IL-8 mRNA levels were elevated at the end of hour 1 (P=.009) with respect to the control group, but not thereafter. Interstitial changes were minimal. IL-8 mRNA levels during reperfusion were similar to those observed during ischemia, with a slight increase at the end of hour 2. There were no significant differences between hours 1, 2, and 3. Polymorphonuclear neutrophil recruitment occurred at the beginning of reperfusion (P=.014), but no significant differences were observed at hours 2 or 3. Progressive thickening of alveolar septa and edema was documented. Changes in IL-8 mRNA expression during ischemia precede interstitial infiltration by polymorphonuclear neutrophils during reperfusion, suggesting that the 2 processes are related. Quantification of IL-8 mRNA expression could facilitate early diagnosis of graft dysfunction. La generación local de citocinas es un factor patogénico en el daño por isquemia-reperfusión en la disfunción precoz del injerto. Este estudio analiza la expresión en tejido pulmonar de ARN mensajero de interleucina-8 (ARNm de IL-8) y su relación con los cambios intersticiales pulmonares en un modelo experimental de isquemia-reperfusión pulmonar normotérmica. Se estudiaron 16 conejos de la raza Nueva Zelanda en 3 grupos de estudio: a) basal; b) isquemia (lóbulo inferior derecho tras isquemia de 1, 2 o 3 h), y c) reperfusión (lóbulos superior y medio derechos tras 1 h de isquemia y 1, 2 o 3 h de reperfusión). Se deter- minó la expresión del ARNm de IL-8 mediante transcripción inversa y reacción en cadena de la polimerasa y estudió la infiltración intersticial por polimorfonucleares (PMN). Para el análisis estadístico se empleó el test de la U de Mann-Whitney aceptando como significativo un valor de p < 0,05. Durante el período de isquemia se observó respecto al basal elevación del ARNm de IL-8 al final de la primera hora (p = 0,009), pero no durante el resto del período isquémico. Los cambios intersticiales fueron mínimos. Durante la reperfusión los valores de ARNm de IL-8 fueron semejantes a los observados durante la isquemia, con una ligera elevación al final de segunda hora; no hubo diferencias significativas entre la primera, segunda y tercera horas. Hubo reclutamiento de PMN al inicio de la reperfusión (p = 0,014), sin observarse diferencias significativas en la segunda y tercera horas. Se objetivó un engrosamiento progresivo de los tabiques interalveolares y edema. Los cambios en la expresión del ARNm de IL-8 durante la isquemia preceden a la infiltración intersticial de PMN durante la reperfusión, lo que señala una relación entre ambos procesos. La cuantificación del ARNm de IL-8 podría ser un procedimiento para el seguimiento diagnóstico de la disfunción precoz del injerto." @default.
• W2171485000 created "2016-06-24" @default.
• W2171485000 creator A5000201213 @default.
• W2171485000 creator A5013455659 @default.
• W2171485000 creator A5018899391 @default.
• W2171485000 creator A5029696197 @default.
• W2171485000 creator A5031865811 @default.
• W2171485000 creator A5072382215 @default.
• W2171485000 creator A5074429354 @default.
• W2171485000 creator A5084267397 @default.
• W2171485000 date "2007-01-01" @default.
• W2171485000 modified "2023-09-23" @default.
• W2171485000 title "Interleukin-8 Expression in Lung Tissue During Ischemia-Reperfusion" @default.
• W2171485000 cites W1584362946 @default.
• W2171485000 cites W1595245989 @default.
• W2171485000 cites W1622862369 @default.
• W2171485000 cites W1968235120 @default.
• W2171485000 cites W1983146632 @default.
• W2171485000 cites W1983688860 @default.
• W2171485000 cites W1989295017 @default.
• W2171485000 cites W2014877991 @default.
• W2171485000 cites W2019253100 @default.
• W2171485000 cites W2020433858 @default.
• W2171485000 cites W2025386529 @default.
• W2171485000 cites W2037882316 @default.
• W2171485000 cites W2044848723 @default.
• W2171485000 cites W2050544650 @default.
• W2171485000 cites W2050579100 @default.
• W2171485000 cites W2059656604 @default.
• W2171485000 cites W2061340886 @default.
• W2171485000 cites W2064492273 @default.
• W2171485000 cites W2129526202 @default.
• W2171485000 cites W2132497066 @default.
• W2171485000 cites W2317223292 @default.
• W2171485000 doi "https://doi.org/10.1016/s1579-2129(07)60125-6" @default.
• W2171485000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17939908" @default.
• W2171485000 hasPublicationYear "2007" @default.
• W2171485000 type Work @default.
• W2171485000 sameAs 2171485000 @default.
• W2171485000 citedByCount "5" @default.
• W2171485000 countsByYear W21714850002012 @default.
• W2171485000 countsByYear W21714850002023 @default.
• W2171485000 crossrefType "journal-article" @default.
• W2171485000 hasAuthorship W2171485000A5000201213 @default.
• W2171485000 hasAuthorship W2171485000A5013455659 @default.
• W2171485000 hasAuthorship W2171485000A5018899391 @default.
• W2171485000 hasAuthorship W2171485000A5029696197 @default.
• W2171485000 hasAuthorship W2171485000A5031865811 @default.
• W2171485000 hasAuthorship W2171485000A5072382215 @default.
• W2171485000 hasAuthorship W2171485000A5074429354 @default.
• W2171485000 hasAuthorship W2171485000A5084267397 @default.
• W2171485000 hasConcept C104317684 @default.
• W2171485000 hasConcept C105580179 @default.
• W2171485000 hasConcept C121332964 @default.
• W2171485000 hasConcept C126322002 @default.
• W2171485000 hasConcept C142724271 @default.
• W2171485000 hasConcept C153400128 @default.
• W2171485000 hasConcept C2777714996 @default.
• W2171485000 hasConcept C2780114680 @default.
• W2171485000 hasConcept C2780886150 @default.
• W2171485000 hasConcept C541997718 @default.
• W2171485000 hasConcept C55493867 @default.
• W2171485000 hasConcept C71924100 @default.
• W2171485000 hasConcept C86803240 @default.
• W2171485000 hasConcept C97355855 @default.
• W2171485000 hasConceptScore W2171485000C104317684 @default.
• W2171485000 hasConceptScore W2171485000C105580179 @default.
• W2171485000 hasConceptScore W2171485000C121332964 @default.
• W2171485000 hasConceptScore W2171485000C126322002 @default.
• W2171485000 hasConceptScore W2171485000C142724271 @default.
• W2171485000 hasConceptScore W2171485000C153400128 @default.
• W2171485000 hasConceptScore W2171485000C2777714996 @default.
• W2171485000 hasConceptScore W2171485000C2780114680 @default.
• W2171485000 hasConceptScore W2171485000C2780886150 @default.
• W2171485000 hasConceptScore W2171485000C541997718 @default.
• W2171485000 hasConceptScore W2171485000C55493867 @default.
• W2171485000 hasConceptScore W2171485000C71924100 @default.
• W2171485000 hasConceptScore W2171485000C86803240 @default.
• W2171485000 hasConceptScore W2171485000C97355855 @default.
• W2171485000 hasIssue "10" @default.
• W2171485000 hasLocation W21714850001 @default.
• W2171485000 hasLocation W21714850002 @default.
• W2171485000 hasOpenAccess W2171485000 @default.
• W2171485000 hasPrimaryLocation W21714850001 @default.
• W2171485000 hasRelatedWork W1971313703 @default.
• W2171485000 hasRelatedWork W2054444769 @default.
• W2171485000 hasRelatedWork W2069198968 @default.
• W2171485000 hasRelatedWork W2073328546 @default.
• W2171485000 hasRelatedWork W2129363868 @default.
• W2171485000 hasRelatedWork W2169094735 @default.
• W2171485000 hasRelatedWork W2362413034 @default.
• W2171485000 hasRelatedWork W2389415086 @default.
• W2171485000 hasRelatedWork W2904528952 @default.
• W2171485000 hasRelatedWork W3149703501 @default.
• W2171485000 hasVolume "43" @default.
• W2171485000 isParatext "false" @default.
• W2171485000 isRetracted "false" @default.
• W2171485000 magId "2171485000" @default.

• next