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- W2171489505 abstract "The ability of environmental estrogens to regulate gene transcription on model and physiologically complex promoterwas examined in GH3 cells, a pituitary cell line. In transient transfection studies, the pGL3 model promoter and thephysiologically complex prolactin promoter were both responsive to the xenoestrogen bisphenol A and thephytoestrogen daidzein in a dose related manner. These transcriptional responses were mediated by estrogen receptors,as responses were ameliorated in the presence of ICI 180, 782, a pure antiestrogen. Cotransfection of Pit-1 significantlyenhanced the transcriptional response of the prolactin promoter to stimulation by environmental estrogens. The natureand magnitude of transcriptional responses to estradiol sensitive genes following challenge by environmental estrogensis likely dependent on regulatory elements found in the promoter and their ability to recruit transcription factors." @default.
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- W2171489505 date "2010-01-01" @default.
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- W2171489505 title "Environmental Estrogens Stimulate Gene Transcription in the Prolactin Promoter" @default.
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- W2171489505 doi "https://doi.org/10.5539/ijb.v2n1p35" @default.
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