FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171494430> ?p ?o ?g. }

• W2171494430 endingPage "1318" @default.
• W2171494430 startingPage "1312" @default.
• W2171494430 abstract "The organic cation transporter 2 (OCT2, SLC22A2) plays an important role for renal drug elimination. Recent clinical studies indicate an impact of the frequent nonsynonymous c.808G>T (p.270Ala>Ser) polymorphism on renal clearance of metformin and the extent of the metformin-cimetidine interaction. The role of this polymorphism for renal disposition of endogenous compounds and drugs other than metformin has not been investigated. In addition, it is unclear whether the observed genotype dependence of an OCT2-mediated drug-drug interaction might occur also with other OCT inhibitors. To address these issues, we generated human embryonic kidney cells stably expressing wild-type OCT2 or the p.270Ala>Ser variant. No differences in protein expression levels and membrane incorporation pattern were observed between the two cell lines. The p.270Ala>Ser variant significantly impaired uptake kinetics of 1-methyl-4-phenylpyridinium, dopamine, norepinephrine, and propranolol. V(max) values were significantly reduced for uptake of all four compounds mediated by the p.270Ala>Ser variant compared with wild-type OCT2. In addition, a significant difference in the affinity to wild-type and mutant OCT2 was observed for dopamine (K(m) dopamine: 932 +/- 77 versus 1285 +/- 132 microM). Moreover, out of a set of 27 compounds p.270Ala>Ser OCT2 was significantly less sensitive to inhibition by cimetidine, flurazepam, metformin, mexiletine, propranolol, and verapamil than wild-type OCT2 (e.g., for propranolol: IC(50) wild type versus p.270Ala>Ser 189 versus 895 microM, P < 0.001). Our results indicate that the common OCT2 c.808G>T single nucleotide polymorphism significantly alters uptake of endogenous compounds and drugs. Moreover, for selected compounds the extent of OCT2-mediated drug interactions could depend on OCT2 c.808G>T genotype." @default.
• W2171494430 created "2016-06-24" @default.
• W2171494430 creator A5002071491 @default.
• W2171494430 creator A5020324921 @default.
• W2171494430 creator A5029302293 @default.
• W2171494430 creator A5030993480 @default.
• W2171494430 date "2009-02-27" @default.
• W2171494430 modified "2023-09-26" @default.
• W2171494430 title "Functional Characterization of the Human Organic Cation Transporter 2 Variant p.270Ala>Ser" @default.
• W2171494430 cites W1275052218 @default.
• W2171494430 cites W1974004642 @default.
• W2171494430 cites W1985730712 @default.
• W2171494430 cites W1989664121 @default.
• W2171494430 cites W1997038641 @default.
• W2171494430 cites W2016382199 @default.
• W2171494430 cites W2021001573 @default.
• W2171494430 cites W2023434765 @default.
• W2171494430 cites W2025894603 @default.
• W2171494430 cites W2027086950 @default.
• W2171494430 cites W2028615902 @default.
• W2171494430 cites W2053912143 @default.
• W2171494430 cites W2055518481 @default.
• W2171494430 cites W2062384361 @default.
• W2171494430 cites W2064203680 @default.
• W2171494430 cites W2071283070 @default.
• W2171494430 cites W2079073137 @default.
• W2171494430 cites W2128564251 @default.
• W2171494430 cites W2133812171 @default.
• W2171494430 cites W2134594247 @default.
• W2171494430 cites W2151903621 @default.
• W2171494430 cites W2157721092 @default.
• W2171494430 cites W2159829769 @default.
• W2171494430 cites W2167325052 @default.
• W2171494430 cites W2196515255 @default.
• W2171494430 doi "https://doi.org/10.1124/dmd.108.023762" @default.
• W2171494430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19251820" @default.
• W2171494430 hasPublicationYear "2009" @default.
• W2171494430 type Work @default.
• W2171494430 sameAs 2171494430 @default.
• W2171494430 citedByCount "78" @default.
• W2171494430 countsByYear W21714944302012 @default.
• W2171494430 countsByYear W21714944302013 @default.
• W2171494430 countsByYear W21714944302014 @default.
• W2171494430 countsByYear W21714944302015 @default.
• W2171494430 countsByYear W21714944302016 @default.
• W2171494430 countsByYear W21714944302017 @default.
• W2171494430 countsByYear W21714944302018 @default.
• W2171494430 countsByYear W21714944302019 @default.
• W2171494430 countsByYear W21714944302020 @default.
• W2171494430 countsByYear W21714944302021 @default.
• W2171494430 countsByYear W21714944302022 @default.
• W2171494430 countsByYear W21714944302023 @default.
• W2171494430 crossrefType "journal-article" @default.
• W2171494430 hasAuthorship W2171494430A5002071491 @default.
• W2171494430 hasAuthorship W2171494430A5020324921 @default.
• W2171494430 hasAuthorship W2171494430A5029302293 @default.
• W2171494430 hasAuthorship W2171494430A5030993480 @default.
• W2171494430 hasConcept C104317684 @default.
• W2171494430 hasConcept C126322002 @default.
• W2171494430 hasConcept C134018914 @default.
• W2171494430 hasConcept C143065580 @default.
• W2171494430 hasConcept C149011108 @default.
• W2171494430 hasConcept C185592680 @default.
• W2171494430 hasConcept C189613389 @default.
• W2171494430 hasConcept C207583985 @default.
• W2171494430 hasConcept C2778151854 @default.
• W2171494430 hasConcept C2780323712 @default.
• W2171494430 hasConcept C2780339425 @default.
• W2171494430 hasConcept C2780719153 @default.
• W2171494430 hasConcept C55493867 @default.
• W2171494430 hasConcept C555293320 @default.
• W2171494430 hasConcept C71924100 @default.
• W2171494430 hasConcept C86803240 @default.
• W2171494430 hasConcept C98274493 @default.
• W2171494430 hasConceptScore W2171494430C104317684 @default.
• W2171494430 hasConceptScore W2171494430C126322002 @default.
• W2171494430 hasConceptScore W2171494430C134018914 @default.
• W2171494430 hasConceptScore W2171494430C143065580 @default.
• W2171494430 hasConceptScore W2171494430C149011108 @default.
• W2171494430 hasConceptScore W2171494430C185592680 @default.
• W2171494430 hasConceptScore W2171494430C189613389 @default.
• W2171494430 hasConceptScore W2171494430C207583985 @default.
• W2171494430 hasConceptScore W2171494430C2778151854 @default.
• W2171494430 hasConceptScore W2171494430C2780323712 @default.
• W2171494430 hasConceptScore W2171494430C2780339425 @default.
• W2171494430 hasConceptScore W2171494430C2780719153 @default.
• W2171494430 hasConceptScore W2171494430C55493867 @default.
• W2171494430 hasConceptScore W2171494430C555293320 @default.
• W2171494430 hasConceptScore W2171494430C71924100 @default.
• W2171494430 hasConceptScore W2171494430C86803240 @default.
• W2171494430 hasConceptScore W2171494430C98274493 @default.
• W2171494430 hasIssue "6" @default.
• W2171494430 hasLocation W21714944301 @default.
• W2171494430 hasLocation W21714944302 @default.
• W2171494430 hasOpenAccess W2171494430 @default.
• W2171494430 hasPrimaryLocation W21714944301 @default.
• W2171494430 hasRelatedWork W1966367806 @default.
• W2171494430 hasRelatedWork W1971444095 @default.

• next