Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171514265> ?p ?o ?g. }
- W2171514265 endingPage "538" @default.
- W2171514265 startingPage "533" @default.
- W2171514265 abstract "Arsenic is naturally occurring element that exists in both organic and inorganic formulations. The inorganic form arsenite has a positive association with development of multiple cancer types. There are significant populations throughout the world with high exposure to arsenite via drinking water. Thus, human exposure to arsenic has become a significant public health problem. Recent evidence suggests that reactive oxygen species (ROS) mediate multiple changes to cell behavior after acute arsenic exposure, including activation of proliferative signaling and angiogenesis. However, the role of ROS in mediating cell transformation by chronic arsenic exposure is unknown. We found that cells chronically exposed to sodium arsenite increased proliferation and gained anchorage-independent growth. This cell transformation phenotype required constitutive activation of AKT, ERK1/2, mTOR, and p70S6K1. We also observed these cells constitutively produce ROS, which was required for the constitutive activation of AKT, ERK1/2, mTOR, and p70S6K1. Suppression of ROS levels by forced expression of catalase also reduced cell proliferation and anchorage-independent growth. These results indicate cell transformation induced by chronic arsenic exposure is mediated by increased cellular levels of ROS, which mediates activation of AKT, ERK1/2, and p70S6K1." @default.
- W2171514265 created "2016-06-24" @default.
- W2171514265 creator A5053401529 @default.
- W2171514265 creator A5063124087 @default.
- W2171514265 creator A5065023946 @default.
- W2171514265 creator A5073093941 @default.
- W2171514265 creator A5074873913 @default.
- W2171514265 creator A5080894648 @default.
- W2171514265 creator A5090816109 @default.
- W2171514265 date "2011-10-01" @default.
- W2171514265 modified "2023-09-30" @default.
- W2171514265 title "Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1" @default.
- W2171514265 cites W1911262314 @default.
- W2171514265 cites W1964305994 @default.
- W2171514265 cites W1971470223 @default.
- W2171514265 cites W1972726130 @default.
- W2171514265 cites W1975727775 @default.
- W2171514265 cites W1988939285 @default.
- W2171514265 cites W1991701837 @default.
- W2171514265 cites W1992676492 @default.
- W2171514265 cites W1995296724 @default.
- W2171514265 cites W1997565776 @default.
- W2171514265 cites W1997889852 @default.
- W2171514265 cites W2015471917 @default.
- W2171514265 cites W2016036988 @default.
- W2171514265 cites W2016536246 @default.
- W2171514265 cites W2019716859 @default.
- W2171514265 cites W2022553472 @default.
- W2171514265 cites W2025603945 @default.
- W2171514265 cites W2027912860 @default.
- W2171514265 cites W2029213094 @default.
- W2171514265 cites W2030868695 @default.
- W2171514265 cites W2055072807 @default.
- W2171514265 cites W2066411725 @default.
- W2171514265 cites W2068386374 @default.
- W2171514265 cites W2080468905 @default.
- W2171514265 cites W2087186233 @default.
- W2171514265 cites W2107462675 @default.
- W2171514265 cites W2109351551 @default.
- W2171514265 cites W2123583425 @default.
- W2171514265 cites W2137168194 @default.
- W2171514265 cites W2143983853 @default.
- W2171514265 cites W2157309969 @default.
- W2171514265 cites W2157453530 @default.
- W2171514265 cites W2160506940 @default.
- W2171514265 doi "https://doi.org/10.1016/j.bbrc.2011.09.102" @default.
- W2171514265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21971544" @default.
- W2171514265 hasPublicationYear "2011" @default.
- W2171514265 type Work @default.
- W2171514265 sameAs 2171514265 @default.
- W2171514265 citedByCount "64" @default.
- W2171514265 countsByYear W21715142652012 @default.
- W2171514265 countsByYear W21715142652013 @default.
- W2171514265 countsByYear W21715142652014 @default.
- W2171514265 countsByYear W21715142652015 @default.
- W2171514265 countsByYear W21715142652016 @default.
- W2171514265 countsByYear W21715142652017 @default.
- W2171514265 countsByYear W21715142652018 @default.
- W2171514265 countsByYear W21715142652019 @default.
- W2171514265 countsByYear W21715142652020 @default.
- W2171514265 countsByYear W21715142652021 @default.
- W2171514265 countsByYear W21715142652022 @default.
- W2171514265 countsByYear W21715142652023 @default.
- W2171514265 crossrefType "journal-article" @default.
- W2171514265 hasAuthorship W2171514265A5053401529 @default.
- W2171514265 hasAuthorship W2171514265A5063124087 @default.
- W2171514265 hasAuthorship W2171514265A5065023946 @default.
- W2171514265 hasAuthorship W2171514265A5073093941 @default.
- W2171514265 hasAuthorship W2171514265A5074873913 @default.
- W2171514265 hasAuthorship W2171514265A5080894648 @default.
- W2171514265 hasAuthorship W2171514265A5090816109 @default.
- W2171514265 hasConcept C178790620 @default.
- W2171514265 hasConcept C185592680 @default.
- W2171514265 hasConcept C2776305511 @default.
- W2171514265 hasConcept C48349386 @default.
- W2171514265 hasConcept C502230775 @default.
- W2171514265 hasConcept C55493867 @default.
- W2171514265 hasConcept C62112901 @default.
- W2171514265 hasConcept C62478195 @default.
- W2171514265 hasConcept C75217442 @default.
- W2171514265 hasConcept C86554907 @default.
- W2171514265 hasConcept C86803240 @default.
- W2171514265 hasConcept C95444343 @default.
- W2171514265 hasConceptScore W2171514265C178790620 @default.
- W2171514265 hasConceptScore W2171514265C185592680 @default.
- W2171514265 hasConceptScore W2171514265C2776305511 @default.
- W2171514265 hasConceptScore W2171514265C48349386 @default.
- W2171514265 hasConceptScore W2171514265C502230775 @default.
- W2171514265 hasConceptScore W2171514265C55493867 @default.
- W2171514265 hasConceptScore W2171514265C62112901 @default.
- W2171514265 hasConceptScore W2171514265C62478195 @default.
- W2171514265 hasConceptScore W2171514265C75217442 @default.
- W2171514265 hasConceptScore W2171514265C86554907 @default.
- W2171514265 hasConceptScore W2171514265C86803240 @default.
- W2171514265 hasConceptScore W2171514265C95444343 @default.
- W2171514265 hasIssue "3" @default.
- W2171514265 hasLocation W21715142651 @default.
- W2171514265 hasLocation W21715142652 @default.