Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171520210> ?p ?o ?g. }
- W2171520210 endingPage "4928" @default.
- W2171520210 startingPage "4914" @default.
- W2171520210 abstract "ABSTRACT We previously described the isolation of ysl2 - 1 due to its genetic interaction with Δ ypt51/vps21 , a mutant with a deletion of the coding sequence for the yeast Rab5 homolog, which regulates endocytic traffic between early and late endosomes. Here we report that Ysl2p is a novel 186.8-kDa peripheral membrane protein homologous to members of the Sec7 family. We provide multiple genetic and biochemical evidence for an interaction between Ysl12p and the Arf-like protein Arl1p, consistent with a potential function as an Arf guanine nucleotide exchange factor (GEF). The temperature-sensitive alleles ysl2 - 307 and ysl2 - 316 are specifically defective in ligand-induced degradation of Ste2p and α-factor and exhibit vacuole fragmentation directly upon a shift to 37°C. In living cells, green fluorescent protein (GFP)-Ysl2p colocalizes with endocytic elements that accumulate FM4-64. The GFP-Ysl2p staining is sensitive to a mutation in VPS27 resulting in the formation of an aberrant class E compartment, but it is not affected by a sec7 mutation. Consistent with the idea that Ysl2p and Arl1p have closely related functions, Δ arl1 cells are defective in endocytic transport and in vacuolar protein sorting." @default.
- W2171520210 created "2016-06-24" @default.
- W2171520210 creator A5028909818 @default.
- W2171520210 creator A5029902333 @default.
- W2171520210 creator A5033186626 @default.
- W2171520210 creator A5073147866 @default.
- W2171520210 creator A5088617574 @default.
- W2171520210 date "2002-07-01" @default.
- W2171520210 modified "2023-09-28" @default.
- W2171520210 title "Yeast Ysl2p, Homologous to Sec7 Domain Guanine Nucleotide Exchange Factors, Functions in Endocytosis and Maintenance of Vacuole Integrity and Interacts with the Arf-Like Small GTPase Arl1p" @default.
- W2171520210 cites W1497885180 @default.
- W2171520210 cites W1526754730 @default.
- W2171520210 cites W1543525864 @default.
- W2171520210 cites W1564648482 @default.
- W2171520210 cites W1566478858 @default.
- W2171520210 cites W1582554042 @default.
- W2171520210 cites W1595083713 @default.
- W2171520210 cites W1673824819 @default.
- W2171520210 cites W1859619881 @default.
- W2171520210 cites W1966072209 @default.
- W2171520210 cites W1975593876 @default.
- W2171520210 cites W1977598234 @default.
- W2171520210 cites W1997293429 @default.
- W2171520210 cites W1998963313 @default.
- W2171520210 cites W2006165666 @default.
- W2171520210 cites W2008475447 @default.
- W2171520210 cites W2019215631 @default.
- W2171520210 cites W2020824066 @default.
- W2171520210 cites W2025059188 @default.
- W2171520210 cites W2030111014 @default.
- W2171520210 cites W2042431220 @default.
- W2171520210 cites W2048697340 @default.
- W2171520210 cites W2054571973 @default.
- W2171520210 cites W2059428912 @default.
- W2171520210 cites W2078959581 @default.
- W2171520210 cites W2080273350 @default.
- W2171520210 cites W2083895131 @default.
- W2171520210 cites W2086906681 @default.
- W2171520210 cites W2090222587 @default.
- W2171520210 cites W2090486711 @default.
- W2171520210 cites W2093006848 @default.
- W2171520210 cites W2098584421 @default.
- W2171520210 cites W2100057937 @default.
- W2171520210 cites W2102424043 @default.
- W2171520210 cites W2102948276 @default.
- W2171520210 cites W2106882534 @default.
- W2171520210 cites W2107180729 @default.
- W2171520210 cites W2110905842 @default.
- W2171520210 cites W2111565848 @default.
- W2171520210 cites W2111612340 @default.
- W2171520210 cites W2124330643 @default.
- W2171520210 cites W2130905895 @default.
- W2171520210 cites W2132460046 @default.
- W2171520210 cites W2134109852 @default.
- W2171520210 cites W2137804377 @default.
- W2171520210 cites W2140752038 @default.
- W2171520210 cites W2142529984 @default.
- W2171520210 cites W2154534551 @default.
- W2171520210 cites W2158714788 @default.
- W2171520210 cites W2185758914 @default.
- W2171520210 cites W3147254695 @default.
- W2171520210 cites W317324549 @default.
- W2171520210 cites W34732 @default.
- W2171520210 cites W74095970 @default.
- W2171520210 doi "https://doi.org/10.1128/mcb.22.13.4914-4928.2002" @default.
- W2171520210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/133889" @default.
- W2171520210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12052896" @default.
- W2171520210 hasPublicationYear "2002" @default.
- W2171520210 type Work @default.
- W2171520210 sameAs 2171520210 @default.
- W2171520210 citedByCount "44" @default.
- W2171520210 countsByYear W21715202102012 @default.
- W2171520210 countsByYear W21715202102013 @default.
- W2171520210 countsByYear W21715202102017 @default.
- W2171520210 countsByYear W21715202102019 @default.
- W2171520210 countsByYear W21715202102020 @default.
- W2171520210 countsByYear W21715202102021 @default.
- W2171520210 countsByYear W21715202102022 @default.
- W2171520210 crossrefType "journal-article" @default.
- W2171520210 hasAuthorship W2171520210A5028909818 @default.
- W2171520210 hasAuthorship W2171520210A5029902333 @default.
- W2171520210 hasAuthorship W2171520210A5033186626 @default.
- W2171520210 hasAuthorship W2171520210A5073147866 @default.
- W2171520210 hasAuthorship W2171520210A5088617574 @default.
- W2171520210 hasBestOaLocation W21715202102 @default.
- W2171520210 hasConcept C102568950 @default.
- W2171520210 hasConcept C104317684 @default.
- W2171520210 hasConcept C119062480 @default.
- W2171520210 hasConcept C124682485 @default.
- W2171520210 hasConcept C126619667 @default.
- W2171520210 hasConcept C158617107 @default.
- W2171520210 hasConcept C170493617 @default.
- W2171520210 hasConcept C190062978 @default.
- W2171520210 hasConcept C207332259 @default.
- W2171520210 hasConcept C2777576037 @default.
- W2171520210 hasConcept C2779222958 @default.
- W2171520210 hasConcept C2780298669 @default.
- W2171520210 hasConcept C28005876 @default.