Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171547926> ?p ?o ?g. }
- W2171547926 endingPage "1057" @default.
- W2171547926 startingPage "1032" @default.
- W2171547926 abstract "In the present study, developmental and reproductive effects of lifelong exposure to environmental relevant concentrations of two natural mixtures of persistent organic pollutants (POP) were investigated using classical and molecular methods in a controlled zebrafish model. The mixtures used were extracted from burbot ( Lota lota ) liver originating from freshwater systems in Norway: one mixture with high levels and one mixture with background levels of polybrominated diphenyl ethers (PBDE), polychlorinated biphenyls (PCB), and dichlorodiphenyltrichloroethane metabolites (DDT). The concentration of POP measured in the zebrafish ranged from levels detected in wild fish from Lake Mjøsa to concentrations reported in human and wildlife populations, indicating that the experimental fish were exposed to concentrations comparable with wild fish. Phenotypic effects observed in both exposure groups included earlier onset of puberty, increased male/female sex ratio, and differences in body weight at 5 mo of age. Interestingly, genome-wide transcription profiling showed changes in regulation of genes involved in endocrine signaling and growth. The transcriptomics changes include key regulator genes for steroid hormone functions ( ncoa3 ), and growth (c/ebp, ncoa3 ). The effects observed in the experimental zebrafish model raise the question whether chemical pollution represents a risk to reproductive health of wild fish inhabitating the freshwater system." @default.
- W2171547926 created "2016-06-24" @default.
- W2171547926 creator A5002965139 @default.
- W2171547926 creator A5004267603 @default.
- W2171547926 creator A5042284531 @default.
- W2171547926 creator A5050386800 @default.
- W2171547926 creator A5056963337 @default.
- W2171547926 creator A5058835759 @default.
- W2171547926 creator A5073946687 @default.
- W2171547926 creator A5090129454 @default.
- W2171547926 date "2010-06-14" @default.
- W2171547926 modified "2023-10-18" @default.
- W2171547926 title "Natural Mixtures of Persistent Organic Pollutants (POP) Increase Weight Gain, Advance Puberty, and Induce Changes in Gene Expression Associated with Steroid Hormones and Obesity in Female Zebrafish" @default.
- W2171547926 cites W150450883 @default.
- W2171547926 cites W1586247554 @default.
- W2171547926 cites W1922704711 @default.
- W2171547926 cites W1971641550 @default.
- W2171547926 cites W1972087205 @default.
- W2171547926 cites W1972942507 @default.
- W2171547926 cites W1979189634 @default.
- W2171547926 cites W1980508602 @default.
- W2171547926 cites W1980998628 @default.
- W2171547926 cites W1983020752 @default.
- W2171547926 cites W1991371264 @default.
- W2171547926 cites W2004572418 @default.
- W2171547926 cites W2005084421 @default.
- W2171547926 cites W2007747507 @default.
- W2171547926 cites W2013444425 @default.
- W2171547926 cites W2019007589 @default.
- W2171547926 cites W2020393862 @default.
- W2171547926 cites W2025258565 @default.
- W2171547926 cites W2025358151 @default.
- W2171547926 cites W2027623707 @default.
- W2171547926 cites W2029867191 @default.
- W2171547926 cites W2031731336 @default.
- W2171547926 cites W2038711150 @default.
- W2171547926 cites W2039637381 @default.
- W2171547926 cites W2039871782 @default.
- W2171547926 cites W2040361144 @default.
- W2171547926 cites W2041846642 @default.
- W2171547926 cites W2041896828 @default.
- W2171547926 cites W2045715853 @default.
- W2171547926 cites W2050118432 @default.
- W2171547926 cites W2050810869 @default.
- W2171547926 cites W2050986991 @default.
- W2171547926 cites W2052032735 @default.
- W2171547926 cites W2057845792 @default.
- W2171547926 cites W2060410246 @default.
- W2171547926 cites W2061971952 @default.
- W2171547926 cites W2062948983 @default.
- W2171547926 cites W2067969527 @default.
- W2171547926 cites W2070956362 @default.
- W2171547926 cites W2074289120 @default.
- W2171547926 cites W2075094290 @default.
- W2171547926 cites W2078252528 @default.
- W2171547926 cites W2079149091 @default.
- W2171547926 cites W2079596704 @default.
- W2171547926 cites W2081090961 @default.
- W2171547926 cites W2081225531 @default.
- W2171547926 cites W2082802165 @default.
- W2171547926 cites W2083416363 @default.
- W2171547926 cites W2087673629 @default.
- W2171547926 cites W2094022965 @default.
- W2171547926 cites W2099745025 @default.
- W2171547926 cites W2101470202 @default.
- W2171547926 cites W2101951807 @default.
- W2171547926 cites W2105856315 @default.
- W2171547926 cites W2114041290 @default.
- W2171547926 cites W2114696635 @default.
- W2171547926 cites W2115662854 @default.
- W2171547926 cites W2117923938 @default.
- W2171547926 cites W2129008449 @default.
- W2171547926 cites W2132024398 @default.
- W2171547926 cites W2137645986 @default.
- W2171547926 cites W2139746114 @default.
- W2171547926 cites W2142415307 @default.
- W2171547926 cites W2147422622 @default.
- W2171547926 cites W2148244700 @default.
- W2171547926 cites W2151574084 @default.
- W2171547926 cites W2156355236 @default.
- W2171547926 cites W2159876804 @default.
- W2171547926 cites W2162811628 @default.
- W2171547926 cites W2165849895 @default.
- W2171547926 cites W2167486734 @default.
- W2171547926 cites W2167787018 @default.
- W2171547926 cites W4231356650 @default.
- W2171547926 cites W4237916691 @default.
- W2171547926 cites W911831223 @default.
- W2171547926 doi "https://doi.org/10.1080/15287394.2010.481618" @default.
- W2171547926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20526952" @default.
- W2171547926 hasPublicationYear "2010" @default.
- W2171547926 type Work @default.
- W2171547926 sameAs 2171547926 @default.
- W2171547926 citedByCount "61" @default.
- W2171547926 countsByYear W21715479262012 @default.
- W2171547926 countsByYear W21715479262013 @default.
- W2171547926 countsByYear W21715479262014 @default.
- W2171547926 countsByYear W21715479262015 @default.