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• W2171556594 endingPage "e26071" @default.
• W2171556594 startingPage "e26071" @default.
• W2171556594 abstract "The growing interest in quantifying the molecular basis of protein kinase activation and allosteric regulation by cancer mutations has fueled computational studies of allosteric signaling in protein kinases. In the present study, we combined computer simulations and the energy landscape analysis of protein kinases to characterize the interplay between oncogenic mutations and locally frustrated sites as important catalysts of allostetric kinase activation. While structurally rigid kinase core constitutes a minimally frustrated hub of the catalytic domain, locally frustrated residue clusters, whose interaction networks are not energetically optimized, are prone to dynamic modulation and could enable allosteric conformational transitions. The results of this study have shown that the energy landscape effect of oncogenic mutations may be allosteric eliciting global changes in the spatial distribution of highly frustrated residues. We have found that mutation-induced allosteric signaling may involve a dynamic coupling between structurally rigid (minimally frustrated) and plastic (locally frustrated) clusters of residues. The presented study has demonstrated that activation cancer mutations may affect the thermodynamic equilibrium between kinase states by allosterically altering the distribution of locally frustrated sites and increasing the local frustration in the inactive form, while eliminating locally frustrated sites and restoring structural rigidity of the active form. The energy landsape analysis of protein kinases and the proposed role of locally frustrated sites in activation mechanisms may have useful implications for bioinformatics-based screening and detection of functional sites critical for allosteric regulation in complex biomolecular systems." @default.
• W2171556594 created "2016-06-24" @default.
• W2171556594 creator A5009132569 @default.
• W2171556594 creator A5031922505 @default.
• W2171556594 date "2011-10-06" @default.
• W2171556594 modified "2023-10-13" @default.
• W2171556594 title "The Energy Landscape Analysis of Cancer Mutations in Protein Kinases" @default.
• W2171556594 cites W1690887682 @default.
• W2171556594 cites W1926851645 @default.
• W2171556594 cites W1965076207 @default.
• W2171556594 cites W1966103056 @default.
• W2171556594 cites W1967796318 @default.
• W2171556594 cites W1968091681 @default.
• W2171556594 cites W1968464319 @default.
• W2171556594 cites W1970174659 @default.
• W2171556594 cites W1972964958 @default.
• W2171556594 cites W1974105492 @default.
• W2171556594 cites W1976051941 @default.
• W2171556594 cites W1976499671 @default.
• W2171556594 cites W1978343870 @default.
• W2171556594 cites W1978943385 @default.
• W2171556594 cites W1979948766 @default.
• W2171556594 cites W1980045457 @default.
• W2171556594 cites W1980374511 @default.
• W2171556594 cites W1980590401 @default.
• W2171556594 cites W1983834639 @default.
• W2171556594 cites W1984852348 @default.
• W2171556594 cites W1988688258 @default.
• W2171556594 cites W1988837867 @default.
• W2171556594 cites W1989213989 @default.
• W2171556594 cites W1991194470 @default.
• W2171556594 cites W1991764480 @default.
• W2171556594 cites W1992784105 @default.
• W2171556594 cites W1992931339 @default.
• W2171556594 cites W1992945955 @default.
• W2171556594 cites W1994762541 @default.
• W2171556594 cites W1998093640 @default.
• W2171556594 cites W1998171084 @default.
• W2171556594 cites W1998367993 @default.
• W2171556594 cites W2000025256 @default.
• W2171556594 cites W2000390423 @default.
• W2171556594 cites W2002767842 @default.
• W2171556594 cites W2003229373 @default.
• W2171556594 cites W2005080874 @default.
• W2171556594 cites W2005392755 @default.
• W2171556594 cites W2005474992 @default.
• W2171556594 cites W2007832948 @default.
• W2171556594 cites W2009123297 @default.
• W2171556594 cites W2012490272 @default.
• W2171556594 cites W2014425795 @default.
• W2171556594 cites W2015403140 @default.
• W2171556594 cites W2015870840 @default.
• W2171556594 cites W2017792882 @default.
• W2171556594 cites W2018981978 @default.
• W2171556594 cites W2022402563 @default.
• W2171556594 cites W2022609682 @default.
• W2171556594 cites W2027408247 @default.
• W2171556594 cites W2028415754 @default.
• W2171556594 cites W2028876207 @default.
• W2171556594 cites W2029118067 @default.
• W2171556594 cites W2029667189 @default.
• W2171556594 cites W2030205108 @default.
• W2171556594 cites W2031094493 @default.
• W2171556594 cites W2034299708 @default.
• W2171556594 cites W2040232982 @default.
• W2171556594 cites W2041415161 @default.
• W2171556594 cites W2042629507 @default.
• W2171556594 cites W2043789128 @default.
• W2171556594 cites W2049682677 @default.
• W2171556594 cites W2050046701 @default.
• W2171556594 cites W2051341715 @default.
• W2171556594 cites W2052420692 @default.
• W2171556594 cites W2053960740 @default.
• W2171556594 cites W2054752913 @default.
• W2171556594 cites W2055823413 @default.
• W2171556594 cites W2057594534 @default.
• W2171556594 cites W2058130956 @default.
• W2171556594 cites W2059044388 @default.
• W2171556594 cites W2059521474 @default.
• W2171556594 cites W2061579713 @default.
• W2171556594 cites W2065717473 @default.
• W2171556594 cites W2073495809 @default.
• W2171556594 cites W2074511635 @default.
• W2171556594 cites W2077804275 @default.
• W2171556594 cites W2079398727 @default.
• W2171556594 cites W2079620307 @default.
• W2171556594 cites W2080590432 @default.
• W2171556594 cites W2083975423 @default.
• W2171556594 cites W2085928981 @default.
• W2171556594 cites W2086204383 @default.
• W2171556594 cites W2092006899 @default.
• W2171556594 cites W2095145098 @default.
• W2171556594 cites W2095745765 @default.
• W2171556594 cites W2097412382 @default.
• W2171556594 cites W2098419466 @default.
• W2171556594 cites W2098968010 @default.
• W2171556594 cites W2099203391 @default.
• W2171556594 cites W2100358815 @default.

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