FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171557357> ?p ?o ?g. }

• W2171557357 endingPage "1466S" @default.
• W2171557357 startingPage "1459S" @default.
• W2171557357 abstract "The maintenance of discrete subcellular pools of zinc (Zn) is critical for the functional and structural integrity of cells. Among the important biological processes influenced by Zn is apoptosis, a process that is important in cellular homeostasis (an important cellular homeostatic process). It has also been identified as a major mechanism contributing to cell death in response to toxins and in disease, offering hope that novel therapies that target apoptotic pathways may be developed. Because Zn levels in the body can be increased in a relatively nontoxic manner, it may be possible to prevent or ameliorate degenerative disorders that are associated with high rates of apoptotic cell death. This review begins with brief introductions that address, first, the cellular biology of Zn, especially the critical labile Zn pools, and, second, the phenomenon of apoptosis. We then review the evidence relating Zn to apoptosis and address three major hypotheses: (1) that a specific pool or pools of intracellular labile Zn regulates apoptosis; (2) that systemic changes in Zn levels in the body, due to dietary factors, altered physiological states or disease, can influence cell susceptibility to apoptosis, and (3) that this altered susceptibility to apoptosis contributes to pathophysiological changes in the body. Other key issues are the identity of the molecular targets of Zn in the apoptotic cascade, the types of cells and tissues most susceptible to Zn-regulated apoptosis, the role of Zn as a coordinate regulator of mitosis and apoptosis and the apparent release of tightly bound intracellular pools of Zn during the later stages of apoptosis. This review concludes with a section highlighting areas of priority for future studies." @default.
• W2171557357 created "2016-06-24" @default.
• W2171557357 creator A5017398739 @default.
• W2171557357 creator A5037713568 @default.
• W2171557357 creator A5063077496 @default.
• W2171557357 creator A5073488824 @default.
• W2171557357 date "2000-05-01" @default.
• W2171557357 modified "2023-10-16" @default.
• W2171557357 title "Cellular Zinc Fluxes and the Regulation of Apoptosis/Gene-Directed Cell Death" @default.
• W2171557357 cites W124849053 @default.
• W2171557357 cites W1559184092 @default.
• W2171557357 cites W157666778 @default.
• W2171557357 cites W1836761553 @default.
• W2171557357 cites W1915857360 @default.
• W2171557357 cites W1916482672 @default.
• W2171557357 cites W1964100162 @default.
• W2171557357 cites W1967183934 @default.
• W2171557357 cites W1969611489 @default.
• W2171557357 cites W1969915582 @default.
• W2171557357 cites W1974040120 @default.
• W2171557357 cites W1988641747 @default.
• W2171557357 cites W1992580705 @default.
• W2171557357 cites W1998617310 @default.
• W2171557357 cites W2001572152 @default.
• W2171557357 cites W2002366112 @default.
• W2171557357 cites W2002945872 @default.
• W2171557357 cites W2010842408 @default.
• W2171557357 cites W2021209937 @default.
• W2171557357 cites W2021369700 @default.
• W2171557357 cites W2023360891 @default.
• W2171557357 cites W2025369435 @default.
• W2171557357 cites W2027642546 @default.
• W2171557357 cites W2032393510 @default.
• W2171557357 cites W2034917512 @default.
• W2171557357 cites W2040810776 @default.
• W2171557357 cites W2042479965 @default.
• W2171557357 cites W2045563337 @default.
• W2171557357 cites W2046557163 @default.
• W2171557357 cites W2061497413 @default.
• W2171557357 cites W2062884465 @default.
• W2171557357 cites W2065798478 @default.
• W2171557357 cites W2076445114 @default.
• W2171557357 cites W2086493438 @default.
• W2171557357 cites W2089540661 @default.
• W2171557357 cites W2107568151 @default.
• W2171557357 cites W2110652761 @default.
• W2171557357 cites W2116690382 @default.
• W2171557357 cites W2124684134 @default.
• W2171557357 cites W2128239350 @default.
• W2171557357 cites W2142301272 @default.
• W2171557357 cites W2145664512 @default.
• W2171557357 cites W2165637297 @default.
• W2171557357 cites W2166151945 @default.
• W2171557357 cites W2171483351 @default.
• W2171557357 cites W2172205541 @default.
• W2171557357 cites W2335055505 @default.
• W2171557357 cites W2398982390 @default.
• W2171557357 cites W2893402662 @default.
• W2171557357 doi "https://doi.org/10.1093/jn/130.5.1459s" @default.
• W2171557357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10801960" @default.
• W2171557357 hasPublicationYear "2000" @default.
• W2171557357 type Work @default.
• W2171557357 sameAs 2171557357 @default.
• W2171557357 citedByCount "203" @default.
• W2171557357 countsByYear W21715573572012 @default.
• W2171557357 countsByYear W21715573572013 @default.
• W2171557357 countsByYear W21715573572014 @default.
• W2171557357 countsByYear W21715573572015 @default.
• W2171557357 countsByYear W21715573572016 @default.
• W2171557357 countsByYear W21715573572017 @default.
• W2171557357 countsByYear W21715573572018 @default.
• W2171557357 countsByYear W21715573572019 @default.
• W2171557357 countsByYear W21715573572020 @default.
• W2171557357 countsByYear W21715573572021 @default.
• W2171557357 countsByYear W21715573572022 @default.
• W2171557357 countsByYear W21715573572023 @default.
• W2171557357 crossrefType "journal-article" @default.
• W2171557357 hasAuthorship W2171557357A5017398739 @default.
• W2171557357 hasAuthorship W2171557357A5037713568 @default.
• W2171557357 hasAuthorship W2171557357A5063077496 @default.
• W2171557357 hasAuthorship W2171557357A5073488824 @default.
• W2171557357 hasBestOaLocation W21715573571 @default.
• W2171557357 hasConcept C104317684 @default.
• W2171557357 hasConcept C1491633281 @default.
• W2171557357 hasConcept C190283241 @default.
• W2171557357 hasConcept C28859421 @default.
• W2171557357 hasConcept C31573885 @default.
• W2171557357 hasConcept C55493867 @default.
• W2171557357 hasConcept C63645605 @default.
• W2171557357 hasConcept C6929976 @default.
• W2171557357 hasConcept C79879829 @default.
• W2171557357 hasConcept C86803240 @default.
• W2171557357 hasConcept C95444343 @default.
• W2171557357 hasConceptScore W2171557357C104317684 @default.
• W2171557357 hasConceptScore W2171557357C1491633281 @default.
• W2171557357 hasConceptScore W2171557357C190283241 @default.
• W2171557357 hasConceptScore W2171557357C28859421 @default.
• W2171557357 hasConceptScore W2171557357C31573885 @default.

• next