Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171559244> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2171559244 endingPage "1065" @default.
- W2171559244 startingPage "1062" @default.
- W2171559244 abstract "Data on the risk of Clostridium difficile infection (CDI) associated with specific antibiotics are difficult to obtain because of confounding clinical factors. It is particularly important to evaluate the propensity of new antibiotics to induce CDI. We have examined the propensity of tigecycline to induce CDI using a human gut model.We used a three-stage chemostat human gut model to study the effects of tigecycline on indigenous gut microflora and C. difficile. Two epidemic C. difficile were studied in separate experiments: PCR ribotype 001 (UK, CD001) and PCR ribotype 027 (North America, CD027). Tigecycline MICs for 39 C. difficile representing 19 distinct PCR ribotypes were also determined.Tigecycline MICs were 0.06 mg/L for all the C. difficile strains. Peak tigecycline concentrations in the gut model were 10.9 and 11.7 mg/L in CD027 and CD001 experiments, respectively. Tigecycline instillation invoked marked decreases in numbers of bacteroides and bifidobacteria (10(7)-10(8) cfu/mL) and lesser reductions in facultative anaerobes. Despite markedly altered gut microflora, CD001 and CD027 remained as spores for the duration of the experiment, with no evidence of proliferation or cytotoxin production.Tigecycline exposure did not induce C. difficile proliferation or cytotoxin production despite reduced competing microflora. The potency of tigecycline against C. difficile may contribute to the low risk of CDI induction. Factors other than gut microflora colonization resistance may be important in preventing C. difficile spore germination, proliferation and cytotoxin production." @default.
- W2171559244 created "2016-06-24" @default.
- W2171559244 creator A5027928189 @default.
- W2171559244 creator A5032222523 @default.
- W2171559244 creator A5067909596 @default.
- W2171559244 creator A5086749897 @default.
- W2171559244 date "2006-09-06" @default.
- W2171559244 modified "2023-09-23" @default.
- W2171559244 title "Tigecycline does not induce proliferation or cytotoxin production by epidemic Clostridium difficile strains in a human gut model" @default.
- W2171559244 cites W1581962345 @default.
- W2171559244 cites W1821236203 @default.
- W2171559244 cites W1974640328 @default.
- W2171559244 cites W2073339113 @default.
- W2171559244 cites W2095874856 @default.
- W2171559244 cites W2096284531 @default.
- W2171559244 cites W2119853161 @default.
- W2171559244 cites W2156737450 @default.
- W2171559244 cites W2157261845 @default.
- W2171559244 doi "https://doi.org/10.1093/jac/dkl364" @default.
- W2171559244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17030519" @default.
- W2171559244 hasPublicationYear "2006" @default.
- W2171559244 type Work @default.
- W2171559244 sameAs 2171559244 @default.
- W2171559244 citedByCount "73" @default.
- W2171559244 countsByYear W21715592442012 @default.
- W2171559244 countsByYear W21715592442013 @default.
- W2171559244 countsByYear W21715592442014 @default.
- W2171559244 countsByYear W21715592442015 @default.
- W2171559244 countsByYear W21715592442016 @default.
- W2171559244 countsByYear W21715592442017 @default.
- W2171559244 countsByYear W21715592442018 @default.
- W2171559244 countsByYear W21715592442019 @default.
- W2171559244 countsByYear W21715592442020 @default.
- W2171559244 countsByYear W21715592442021 @default.
- W2171559244 countsByYear W21715592442022 @default.
- W2171559244 crossrefType "journal-article" @default.
- W2171559244 hasAuthorship W2171559244A5027928189 @default.
- W2171559244 hasAuthorship W2171559244A5032222523 @default.
- W2171559244 hasAuthorship W2171559244A5067909596 @default.
- W2171559244 hasAuthorship W2171559244A5086749897 @default.
- W2171559244 hasBestOaLocation W21715592441 @default.
- W2171559244 hasConcept C2777027569 @default.
- W2171559244 hasConcept C2780246119 @default.
- W2171559244 hasConcept C2994496256 @default.
- W2171559244 hasConcept C501593827 @default.
- W2171559244 hasConcept C86803240 @default.
- W2171559244 hasConcept C89423630 @default.
- W2171559244 hasConceptScore W2171559244C2777027569 @default.
- W2171559244 hasConceptScore W2171559244C2780246119 @default.
- W2171559244 hasConceptScore W2171559244C2994496256 @default.
- W2171559244 hasConceptScore W2171559244C501593827 @default.
- W2171559244 hasConceptScore W2171559244C86803240 @default.
- W2171559244 hasConceptScore W2171559244C89423630 @default.
- W2171559244 hasIssue "5" @default.
- W2171559244 hasLocation W21715592441 @default.
- W2171559244 hasLocation W21715592442 @default.
- W2171559244 hasOpenAccess W2171559244 @default.
- W2171559244 hasPrimaryLocation W21715592441 @default.
- W2171559244 hasRelatedWork W1996732592 @default.
- W2171559244 hasRelatedWork W2016617353 @default.
- W2171559244 hasRelatedWork W2063907463 @default.
- W2171559244 hasRelatedWork W2113335688 @default.
- W2171559244 hasRelatedWork W2121330060 @default.
- W2171559244 hasRelatedWork W2171559244 @default.
- W2171559244 hasRelatedWork W2324051063 @default.
- W2171559244 hasRelatedWork W2419047482 @default.
- W2171559244 hasRelatedWork W2801332876 @default.
- W2171559244 hasRelatedWork W3137540567 @default.
- W2171559244 hasVolume "58" @default.
- W2171559244 isParatext "false" @default.
- W2171559244 isRetracted "false" @default.
- W2171559244 magId "2171559244" @default.
- W2171559244 workType "article" @default.