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- W2171566512 abstract "The parameters of myelin development were ascertained in two specific regions of the corpus callosum in a series of cats aged 12 postnatal days through adult. The posteriormost portion of the splenium and the anterior-most portion of the genu were examined in cross section by using the electron microscope. Measurements were made to determine the age at which myelin first appeared, the number and distribution of myelinated fibers, the number and distribution of myelin lamellae, and cross-sectional area of ensheathed axons during development. The results indicate that myelination begins and ends earlier in the anterior region of the callosum. Measurements of myelin lamellae indicate similarities between anterior and posterior regions of the callosum, although development occurs earlier in the genu than in the splenium. No evidence was found for a sequence in the size of axons acquiring myelin sheaths, except that extremely small fibers are the last to begin myelinating. Myelination of the splenium of the corpus callosum begins at the very end of the behaviorial and physiological critical period for the corpus callosum's role in visual functional development (Elberger: Behav. Brain Res. 11:223–231, '84; Elberger and Smith: Exp. Brain Res. 57:213–223,'85). Since myelination of a pathway is used as an index of functional reliability, this indicates that the basis for the callosal role in developing visual functions is probably not based on its physiological input to visual cortex." @default.
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- W2171566512 date "1986-06-15" @default.
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- W2171566512 title "Myelination of the corpus callosum in the cat: Time course, topography, and functional implications" @default.
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- W2171566512 doi "https://doi.org/10.1002/cne.902480304" @default.
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