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- W2171567386 abstract "Gd-Ethoxybenzyl-DTPA (Gd-EOB-DTPA) is a highly water-soluble paramagnetic contrast agent. Due to its protein binding of about 10% and its lipophilic residue, Gd-EOB-DTPA exhibits both renal (30% of the dose) and hepatobiliary (70%) excretion in rats. Despite its lipohilic character, the compound displays a low toxicity (LD50 = 7.5 mmol/kg). T1-relaxivity of 5.3 liters mmol−1 s−1 in water, 8.7 liters mmol−1 s−1 in plasma, and 16.9 liters mmol−1 s−1 in rat liver together with the hepatocellular uptake explain the liverspecific contrast enhancement of Gd-EOB-DTPA. The diagnostic dose is considerably lower than the amount of Magnevist used in abdominal imaging. The preclinical studies suggest its clinical role as being a hepatobiliary contrast agent for MRI. © 1991 Academic Press, Inc." @default.
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- W2171567386 date "1991-12-01" @default.
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- W2171567386 title "A new lipophilic gadolinium chelate as a tissue-specific contrast medium for MRI" @default.
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- W2171567386 doi "https://doi.org/10.1002/mrm.1910220214" @default.
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