FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171569289> ?p ?o ?g. }

• W2171569289 endingPage "G259" @default.
• W2171569289 startingPage "G252" @default.
• W2171569289 abstract "In cirrhosis, despite augmented blood volume, effective circulating volume is decreased. This implies abnormal regulation of blood volume, i.e., venous pooling. Because gut veins are the main blood reservoir, we studied mesenteric venous capacitance and compliance in a rat model of cirrhosis. Cirrhosis was induced by bile duct ligation (4 wk). Controls were sham operated. Changes in first-order mesenteric vein diameters induced by drugs, hemorrhage, and stepwise increases in portal pressure (inflatable cuff) were directly observed by intravital microscopy. Effects of nitric oxide on responses to acute graded hemorrhage were studied by use of selective NO synthase (NOS) isoform inhibitors. Pressures were related to diameters to assess capacitance and compliance. Compared with controls, cirrhotic rats demonstrated increased mesenteric venous capacitance and decreased compliance. Norepinephrine induced venoconstriction but did not affect compliance. Prazosin markedly diminished compliance in controls but not cirrhotics. Conversely, the nonspecific NOS inhibitor N-nitro-l-arginine methyl ester (l-NAME) decreased compliance in cirrhotics, but not controls. Tetrodotoxin venodilated controls, venoconstricted cirrhotics, and markedly decreased compliance in both groups. When hemorrhaged, controls rapidly venoconstricted to compensate for initial hypotension, whereas cirrhotic rats remained hypotensive because venoconstriction was severely blunted. Pretreatment with l-NAME or the selective neuronal NOS inhibitors S-methyl-l-thiocitrulline and 7-nitroindazole normalized the homeostatic responses of cirrhotic rats, whereas the selective endothelial-constitutive NOS inhibitor N-iminoethyl-l-ornithine did not affect the response. In conclusion, mesenteric veins of cirrhotic rats showed enhanced capacitance, attenuated compensatory constrictive response to hemorrhage, and decreased compliance. The first two abnormalities were caused by neuronal NOS-derived nitric oxide." @default.
• W2171569289 created "2016-06-24" @default.
• W2171569289 creator A5015064556 @default.
• W2171569289 creator A5042678528 @default.
• W2171569289 creator A5058129634 @default.
• W2171569289 creator A5067383696 @default.
• W2171569289 creator A5077803327 @default.
• W2171569289 date "2008-08-01" @default.
• W2171569289 modified "2023-09-27" @default.
• W2171569289 title "Altered mesenteric venous capacitance and volume pooling in cirrhotic rats are mediated by nitric oxide" @default.
• W2171569289 cites W1575024810 @default.
• W2171569289 cites W1664488112 @default.
• W2171569289 cites W1847829426 @default.
• W2171569289 cites W1957251632 @default.
• W2171569289 cites W1975239399 @default.
• W2171569289 cites W1996675559 @default.
• W2171569289 cites W1997652125 @default.
• W2171569289 cites W1999661407 @default.
• W2171569289 cites W2009802087 @default.
• W2171569289 cites W2010240783 @default.
• W2171569289 cites W2020019965 @default.
• W2171569289 cites W2048173082 @default.
• W2171569289 cites W2054641887 @default.
• W2171569289 cites W2055288459 @default.
• W2171569289 cites W2058108960 @default.
• W2171569289 cites W2061949683 @default.
• W2171569289 cites W2062818431 @default.
• W2171569289 cites W2068116361 @default.
• W2171569289 cites W2080262837 @default.
• W2171569289 cites W2089231497 @default.
• W2171569289 cites W2097389213 @default.
• W2171569289 cites W2106547133 @default.
• W2171569289 cites W2123478843 @default.
• W2171569289 cites W2124959346 @default.
• W2171569289 cites W2140325096 @default.
• W2171569289 cites W2158514988 @default.
• W2171569289 cites W2159876288 @default.
• W2171569289 cites W2160233898 @default.
• W2171569289 cites W2187813586 @default.
• W2171569289 cites W2191019337 @default.
• W2171569289 cites W2285539767 @default.
• W2171569289 cites W2410637486 @default.
• W2171569289 doi "https://doi.org/10.1152/ajpgi.00436.2007" @default.
• W2171569289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18556420" @default.
• W2171569289 hasPublicationYear "2008" @default.
• W2171569289 type Work @default.
• W2171569289 sameAs 2171569289 @default.
• W2171569289 citedByCount "12" @default.
• W2171569289 countsByYear W21715692892012 @default.
• W2171569289 countsByYear W21715692892013 @default.
• W2171569289 countsByYear W21715692892015 @default.
• W2171569289 countsByYear W21715692892016 @default.
• W2171569289 countsByYear W21715692892023 @default.
• W2171569289 crossrefType "journal-article" @default.
• W2171569289 hasAuthorship W2171569289A5015064556 @default.
• W2171569289 hasAuthorship W2171569289A5042678528 @default.
• W2171569289 hasAuthorship W2171569289A5058129634 @default.
• W2171569289 hasAuthorship W2171569289A5067383696 @default.
• W2171569289 hasAuthorship W2171569289A5077803327 @default.
• W2171569289 hasConcept C126322002 @default.
• W2171569289 hasConcept C134018914 @default.
• W2171569289 hasConcept C15744967 @default.
• W2171569289 hasConcept C2777214474 @default.
• W2171569289 hasConcept C2777622882 @default.
• W2171569289 hasConcept C2778808290 @default.
• W2171569289 hasConcept C2779065481 @default.
• W2171569289 hasConcept C2779961880 @default.
• W2171569289 hasConcept C2781460075 @default.
• W2171569289 hasConcept C37557685 @default.
• W2171569289 hasConcept C42219234 @default.
• W2171569289 hasConcept C519581460 @default.
• W2171569289 hasConcept C56900294 @default.
• W2171569289 hasConcept C71924100 @default.
• W2171569289 hasConcept C77805123 @default.
• W2171569289 hasConceptScore W2171569289C126322002 @default.
• W2171569289 hasConceptScore W2171569289C134018914 @default.
• W2171569289 hasConceptScore W2171569289C15744967 @default.
• W2171569289 hasConceptScore W2171569289C2777214474 @default.
• W2171569289 hasConceptScore W2171569289C2777622882 @default.
• W2171569289 hasConceptScore W2171569289C2778808290 @default.
• W2171569289 hasConceptScore W2171569289C2779065481 @default.
• W2171569289 hasConceptScore W2171569289C2779961880 @default.
• W2171569289 hasConceptScore W2171569289C2781460075 @default.
• W2171569289 hasConceptScore W2171569289C37557685 @default.
• W2171569289 hasConceptScore W2171569289C42219234 @default.
• W2171569289 hasConceptScore W2171569289C519581460 @default.
• W2171569289 hasConceptScore W2171569289C56900294 @default.
• W2171569289 hasConceptScore W2171569289C71924100 @default.
• W2171569289 hasConceptScore W2171569289C77805123 @default.
• W2171569289 hasIssue "2" @default.
• W2171569289 hasLocation W21715692891 @default.
• W2171569289 hasLocation W21715692892 @default.
• W2171569289 hasOpenAccess W2171569289 @default.
• W2171569289 hasPrimaryLocation W21715692891 @default.
• W2171569289 hasRelatedWork W154779024 @default.
• W2171569289 hasRelatedWork W2001539686 @default.
• W2171569289 hasRelatedWork W2024102156 @default.
• W2171569289 hasRelatedWork W2045471268 @default.

• next