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- W2171569448 abstract "Within the testis, Sertoli cell is the primary target of pituitary FSH. Several growth factors have been described to be produced specifically by Sertoli cells and modulate male germ cell development through paracrine mechanisms. Some have been shown to act directly on spermatogonia such as GDNF, which acts on self-renewal of spermatogonial stem cells (SSCs) while inhibiting their differentiation; BMP4, which has both a proliferative and differentiative effect on these cells, and KL, which stimulates the KIT tyrosine-kinase receptor expressed by differentiating spermatogonia (but not by SSCs). KL not only controls the proliferative cycles of KIT positive spermatogonia, but it also stimulates the expression of genes that are specific of the early phases of meiosis, whereas the expression of typical spermatogonial markers is down-regulated. On the contrary, FGF9 acts as a meiotic inhibiting substance both in fetal gonocytes and in post-natal spermatogonia through the induction of the RNA-binding protein NANOS2. Vitamin A, which is metabolized to Retinoic Acid in Sertoli cells, controls both SSCs differentiation through KIT induction and NANOS2 inhibition, and meiotic entry of differentiating spermatogonia through STRA8 upregulation." @default.
- W2171569448 created "2016-06-24" @default.
- W2171569448 creator A5000467231 @default.
- W2171569448 creator A5081104839 @default.
- W2171569448 date "2013-01-01" @default.
- W2171569448 modified "2023-10-16" @default.
- W2171569448 title "Paracrine Mechanisms Involved in the Control of Early Stages of Mammalian Spermatogenesis" @default.
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- W2171569448 doi "https://doi.org/10.3389/fendo.2013.00181" @default.
- W2171569448 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3840353" @default.
- W2171569448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24324457" @default.
- W2171569448 hasPublicationYear "2013" @default.
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