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- W2171572656 abstract "Abstract The rise in serum calcitonin (Δ‐CT 240 min ) has been measured during hypercalcemia induced by i.v. infusion of calcium gluconate. This calcium infusion test was used in a prospective screening for medullary carcinoma of the thyroid (MCT) in 4 families with Sipple's syndrome as well as in 3 sporadic cases of MCT. In 16 normal controls Δ‐CT 240 was ‐0.2‐+0.5 ng/ml (mean ± 2 S.D.). Δ‐CT 240 was normal in 2 patients with chronic hypocalcemia. In all 14 MCT patients Δ‐CT 240 was markedly higher (min‐max 2.2–630 ng/ml), i.e. no false negatives were found. However, in these cases, the diagnosis was already evident from basal serum calcitonin (S‐CT), which up to now has been our most sensitive diagnostic technique for MCT. 19 first‐degree relatives of patients with Sipple's syndrome presented no signs of MCT. In 14 of these Δ‐CT240 was normal (“healthy relatives”), but in 5 it was slightly elevated, intermediate between the controls and the MCT patients. These 5 borderline cases were more sharply delineated from normal by Δ‐CT 240 than by S‐CT. Thus our calcium infusion test seems to be the most sensitive method for early diagnosis of occult MCT. We recommend the calcium infusion test for: ( a ) screening for MCT in all Sipple relatives with normal or only slightly elevated basal S‐CT, ( b ) postoperative control in both sporadic and hereditary MCT, ( c ) investigation of supposed non‐MCT tumours with calcitonin production." @default.
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- W2171572656 date "1975-01-12" @default.
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- W2171572656 title "SERUM CALCITONIN RESPONSE TO INDUCED HYPERCALCEMIA" @default.
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- W2171572656 doi "https://doi.org/10.1111/j.0954-6820.1975.tb04936.x" @default.
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