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• W2171594570 endingPage "418" @default.
• W2171594570 startingPage "405" @default.
• W2171594570 abstract "Most therapeutic proteins in clinical trials or on the market are, to a variable extent, immunogenic. Formation of antidrug antibodies poses a risk that should be assessed during drug development, as it possibly compromises drug safety and alters pharmacokinetics. The generation of these antibodies is critically dependent on the presence of T helper cell epitopes, which have classically been identified by in vitro methods using blood cells from human donors. As a novel development, in silico methods that identify T cell epitopes have been coming on line. These methods are relatively inexpensive and allow the mapping of epitopes from virtually all human leukocyte antigen molecules derived from a wide genetic background. In vitro assays remain important, but guided by in silico data they can focus on selected peptides and human leukocyte antigen haplotypes, thereby significantly reducing time and cost." @default.
• W2171594570 created "2016-06-24" @default.
• W2171594570 creator A5013144378 @default.
• W2171594570 creator A5039190287 @default.
• W2171594570 creator A5041876254 @default.
• W2171594570 creator A5069115228 @default.
• W2171594570 creator A5072029578 @default.
• W2171594570 date "2007-02-19" @default.
• W2171594570 modified "2023-09-27" @default.
• W2171594570 title "Immunogenicity screening in protein drug development" @default.
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