FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171595778> ?p ?o ?g. }

• W2171595778 endingPage "640" @default.
• W2171595778 startingPage "633" @default.
• W2171595778 abstract "Summary Background A considerable body of human and animal experimental evidence links monoaminergic systems and cognition. Monoamine oxidase inhibitors ( MAOI s), being able to enhance monoaminergic transmission and having neuroprotective properties, might represent a promising therapeutic strategy in cognitive impairment in Alzheimer's disease ( AD ) and other dementias. Methods The MAO ‐A and MAO ‐B inhibition profile of N‐(furan‐2‐ylmethyl)‐N‐prop‐2‐yn‐1‐amine derivates (compounds 1–3) were evaluated by fluorimetric method and their absorption, distribution, metabolism, excretion, and toxicity ( ADMET ) properties estimated. The effects of the selected compound 1, N‐(furan‐2‐ylmethyl)‐N‐methylprop‐2‐yn‐1‐amine (F2 MPA ), were evaluated on the basic synaptic transmission, long‐term potentiation ( LTP ), and excitability in the dentate gyrus (DG) of the hippocampus of anesthetized rats. Results F2MPA is a partially reversible inhibitor of hMAO ‐B, with moderate to good ADMET properties and drug‐likeness. Intraperitoneal administration of 1 mg/kg F2MPA greatly enhanced basic synaptic transmission, induced LTP, and potentiated electrically induced LTP in the dentate gyrus. Moreover, F2MPA did not modify seizure threshold of pilocarpine‐induced convulsion in CD1 mice. Conclusion Our findings suggest that, the MAO ‐B inhibitor, F2 MPA improves DG synaptic transmission without triggering pathological hyperexcitability. Therefore, F2 MPA shows promise as a potential cognition‐enhancing therapeutic drug." @default.
• W2171595778 created "2016-06-24" @default.
• W2171595778 creator A5030733407 @default.
• W2171595778 creator A5036119658 @default.
• W2171595778 creator A5044493452 @default.
• W2171595778 creator A5048038667 @default.
• W2171595778 creator A5052444783 @default.
• W2171595778 creator A5061458064 @default.
• W2171595778 creator A5071785591 @default.
• W2171595778 creator A5079852388 @default.
• W2171595778 creator A5082905681 @default.
• W2171595778 creator A5084849836 @default.
• W2171595778 creator A5085576479 @default.
• W2171595778 creator A5086168624 @default.
• W2171595778 date "2014-05-21" @default.
• W2171595778 modified "2023-09-25" @default.
• W2171595778 title "<i>N</i>-(furan-2-ylmethyl)-<i>N</i>-methylprop-2-yn-1-amine (F2MPA): A Potential Cognitive Enhancer with MAO Inhibitor Properties" @default.
• W2171595778 cites W1566951632 @default.
• W2171595778 cites W1964545163 @default.
• W2171595778 cites W1969887156 @default.
• W2171595778 cites W1970084030 @default.
• W2171595778 cites W1981749670 @default.
• W2171595778 cites W1983333448 @default.
• W2171595778 cites W1986092078 @default.
• W2171595778 cites W1993323116 @default.
• W2171595778 cites W2001405361 @default.
• W2171595778 cites W2009756075 @default.
• W2171595778 cites W2009782005 @default.
• W2171595778 cites W2024332866 @default.
• W2171595778 cites W2033773654 @default.
• W2171595778 cites W2037059312 @default.
• W2171595778 cites W2046725479 @default.
• W2171595778 cites W2049038171 @default.
• W2171595778 cites W2049368373 @default.
• W2171595778 cites W2049511526 @default.
• W2171595778 cites W2054621581 @default.
• W2171595778 cites W2055686915 @default.
• W2171595778 cites W2070271019 @default.
• W2171595778 cites W2071248144 @default.
• W2171595778 cites W2072064154 @default.
• W2171595778 cites W2081651340 @default.
• W2171595778 cites W2084647936 @default.
• W2171595778 cites W2089897685 @default.
• W2171595778 cites W2091505318 @default.
• W2171595778 cites W2092849271 @default.
• W2171595778 cites W2093689511 @default.
• W2171595778 cites W2131697773 @default.
• W2171595778 cites W2161451109 @default.
• W2171595778 cites W2171584675 @default.
• W2171595778 cites W2302113434 @default.
• W2171595778 cites W2335647911 @default.
• W2171595778 cites W2910523044 @default.
• W2171595778 doi "https://doi.org/10.1111/cns.12284" @default.
• W2171595778 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6493173" @default.
• W2171595778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24848125" @default.
• W2171595778 hasPublicationYear "2014" @default.
• W2171595778 type Work @default.
• W2171595778 sameAs 2171595778 @default.
• W2171595778 citedByCount "7" @default.
• W2171595778 countsByYear W21715957782015 @default.
• W2171595778 countsByYear W21715957782016 @default.
• W2171595778 countsByYear W21715957782017 @default.
• W2171595778 countsByYear W21715957782018 @default.
• W2171595778 countsByYear W21715957782019 @default.
• W2171595778 countsByYear W21715957782021 @default.
• W2171595778 crossrefType "journal-article" @default.
• W2171595778 hasAuthorship W2171595778A5030733407 @default.
• W2171595778 hasAuthorship W2171595778A5036119658 @default.
• W2171595778 hasAuthorship W2171595778A5044493452 @default.
• W2171595778 hasAuthorship W2171595778A5048038667 @default.
• W2171595778 hasAuthorship W2171595778A5052444783 @default.
• W2171595778 hasAuthorship W2171595778A5061458064 @default.
• W2171595778 hasAuthorship W2171595778A5071785591 @default.
• W2171595778 hasAuthorship W2171595778A5079852388 @default.
• W2171595778 hasAuthorship W2171595778A5082905681 @default.
• W2171595778 hasAuthorship W2171595778A5084849836 @default.
• W2171595778 hasAuthorship W2171595778A5085576479 @default.
• W2171595778 hasAuthorship W2171595778A5086168624 @default.
• W2171595778 hasBestOaLocation W21715957781 @default.
• W2171595778 hasConcept C15744967 @default.
• W2171595778 hasConcept C169760540 @default.
• W2171595778 hasConcept C170493617 @default.
• W2171595778 hasConcept C185592680 @default.
• W2171595778 hasConcept C187714386 @default.
• W2171595778 hasConcept C25274449 @default.
• W2171595778 hasConcept C2775858608 @default.
• W2171595778 hasConcept C2775864247 @default.
• W2171595778 hasConcept C2776464000 @default.
• W2171595778 hasConcept C2778186239 @default.
• W2171595778 hasConcept C2781161787 @default.
• W2171595778 hasConcept C42251903 @default.
• W2171595778 hasConcept C55493867 @default.
• W2171595778 hasConcept C71924100 @default.
• W2171595778 hasConcept C98274493 @default.
• W2171595778 hasConceptScore W2171595778C15744967 @default.
• W2171595778 hasConceptScore W2171595778C169760540 @default.
• W2171595778 hasConceptScore W2171595778C170493617 @default.
• W2171595778 hasConceptScore W2171595778C185592680 @default.

• next