FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171637756> ?p ?o ?g. }

• W2171637756 abstract "BackgroundMeningococcal polysaccharide (MPLS) vaccines protect against Serogroup C disease, but do not produce an immune response in infants less than two years of age. This limitation can be overcome by linking C polysaccharide to carrier proteins (‘conjugating’), to create meningococcal serogroup C conjugate (MCC) vaccines. In the absence of trial data, the immune response to vaccination has been considered to be a reasonable surrogate for vaccine protection.ObjectivesTo assess the immunogenicity, safety and efficacy of MCC vaccines for preventing meningitis and septicaemia.Search strategyWe searched the Cochrane Central Register Controlled Trials (CENTRAL) (The Cochrane Library Issue 3, 2005); MEDLINE (1966 to September, Week 1 2005); and EMBASE (1990 to June 2005) and references of studies.Selection criteriaRandomised controlled trials (RCTs) and controlled clinical trials (CCTs) in humans comparing MCC vaccines against a control vaccine or none. In the absence of any trials on vaccine efficacy, population-based observational studies about effectiveness were included.Data collection and analysisTwo authors independently screened the results of the literature searches, selected eligible studies, extracted the data and evaluated the quality of them.Main resultsThe studies showed that MCC vaccine was highly immunogenic in infants after two and three doses, in toddlers after one and two doses and in older age groups after one dose. In general higher titres were generated after MCC than after MPLS vaccines. Immunological hypo-responsiveness seen after repeated doses of MPLS vaccine may be overcome with MCC. Observational studies have documented a significant decline in meningococcal C disease in countries where MCC vaccines have been widely used. The timing of the vaccinations schedules, the specific conjugate used, and the vaccines given concomitantly or combined, may be important.Authors' conclusionsThe MCC vaccine appears to be safe, immunogenic and able to induce immunological memory in all age groups. Observational studies strongly suggest that MCC is clinically effective.Plain language summaryTraditional meningococcal polysaccharide (MPLS) vaccines protect against Serogroup C disease (caused by Neisseria meningitidis), but do not produce an immune response in infants less than two years of ageThis limitation can be overcome by linking C polysaccharide to carrier proteins (‘conjugating’), to create meningococcal serogroup C conjugate (MCC) vaccines. This review looks at MCC vaccines to protect young children against Serogroup C disease. Trials found that MCC induces an immune response against serogroup C in all age groups, but especially younger children for whom the immune response is greater than that of the traditional MPLS. It appears to be safe. Clinical efficacy of MCC could not be assessed from randomised controlled clinical trials (there were none). However, weaker evidence from observational studies showed a decrease in meningococcal C disease and meningococcal C carriage in countries where vaccines have been widely used." @default.
• W2171637756 created "2016-06-24" @default.
• W2171637756 creator A5006839148 @default.
• W2171637756 creator A5028745125 @default.
• W2171637756 creator A5085988231 @default.
• W2171637756 creator A5091058877 @default.
• W2171637756 date "2007-01-01" @default.
• W2171637756 modified "2023-09-26" @default.
• W2171637756 title "Cochrane review: Conjugate vaccines for preventing meningococcal C meningitis and septicaemia" @default.
• W2171637756 cites W1845075647 @default.
• W2171637756 cites W1965159450 @default.
• W2171637756 cites W1977302287 @default.
• W2171637756 cites W1982921264 @default.
• W2171637756 cites W1985729698 @default.
• W2171637756 cites W1986215651 @default.
• W2171637756 cites W1991237314 @default.
• W2171637756 cites W1993758434 @default.
• W2171637756 cites W2005143719 @default.
• W2171637756 cites W2025502898 @default.
• W2171637756 cites W2026005942 @default.
• W2171637756 cites W2026303279 @default.
• W2171637756 cites W2032334056 @default.
• W2171637756 cites W2035984862 @default.
• W2171637756 cites W2036187664 @default.
• W2171637756 cites W2042893798 @default.
• W2171637756 cites W2047369361 @default.
• W2171637756 cites W2049628926 @default.
• W2171637756 cites W2054478836 @default.
• W2171637756 cites W2055496928 @default.
• W2171637756 cites W2060925765 @default.
• W2171637756 cites W2067800172 @default.
• W2171637756 cites W2068368401 @default.
• W2171637756 cites W2069778238 @default.
• W2171637756 cites W2072666781 @default.
• W2171637756 cites W2078107959 @default.
• W2171637756 cites W2079581642 @default.
• W2171637756 cites W2080619688 @default.
• W2171637756 cites W2091543537 @default.
• W2171637756 cites W2093741541 @default.
• W2171637756 cites W2097602910 @default.
• W2171637756 cites W2098917747 @default.
• W2171637756 cites W2107271735 @default.
• W2171637756 cites W2107886759 @default.
• W2171637756 cites W2111803865 @default.
• W2171637756 cites W2111955880 @default.
• W2171637756 cites W2114663173 @default.
• W2171637756 cites W2115350923 @default.
• W2171637756 cites W2117982976 @default.
• W2171637756 cites W2118894762 @default.
• W2171637756 cites W2119917603 @default.
• W2171637756 cites W2123686037 @default.
• W2171637756 cites W2125575751 @default.
• W2171637756 cites W2128589740 @default.
• W2171637756 cites W2130460485 @default.
• W2171637756 cites W2130754817 @default.
• W2171637756 cites W2133533552 @default.
• W2171637756 cites W2134625575 @default.
• W2171637756 cites W2139565340 @default.
• W2171637756 cites W2147343091 @default.
• W2171637756 cites W2148076737 @default.
• W2171637756 cites W2148938842 @default.
• W2171637756 cites W2156339347 @default.
• W2171637756 cites W2157295868 @default.
• W2171637756 cites W2159480263 @default.
• W2171637756 cites W2159882102 @default.
• W2171637756 cites W2160828078 @default.
• W2171637756 cites W2160879811 @default.
• W2171637756 cites W2168225301 @default.
• W2171637756 cites W2171902734 @default.
• W2171637756 cites W2314760083 @default.
• W2171637756 cites W2317303250 @default.
• W2171637756 cites W66854821 @default.
• W2171637756 doi "https://doi.org/10.1002/ebch.126" @default.
• W2171637756 hasPublicationYear "2007" @default.
• W2171637756 type Work @default.
• W2171637756 sameAs 2171637756 @default.
• W2171637756 citedByCount "1" @default.
• W2171637756 countsByYear W21716377562012 @default.
• W2171637756 crossrefType "journal-article" @default.
• W2171637756 hasAuthorship W2171637756A5006839148 @default.
• W2171637756 hasAuthorship W2171637756A5028745125 @default.
• W2171637756 hasAuthorship W2171637756A5085988231 @default.
• W2171637756 hasAuthorship W2171637756A5091058877 @default.
• W2171637756 hasConcept C126322002 @default.
• W2171637756 hasConcept C168563851 @default.
• W2171637756 hasConcept C187212893 @default.
• W2171637756 hasConcept C203014093 @default.
• W2171637756 hasConcept C22070199 @default.
• W2171637756 hasConcept C23131810 @default.
• W2171637756 hasConcept C2776478404 @default.
• W2171637756 hasConcept C2778458888 @default.
• W2171637756 hasConcept C2779583294 @default.
• W2171637756 hasConcept C2780441014 @default.
• W2171637756 hasConcept C2780454893 @default.
• W2171637756 hasConcept C2780801004 @default.
• W2171637756 hasConcept C2780868878 @default.
• W2171637756 hasConcept C2781026528 @default.
• W2171637756 hasConcept C2908647359 @default.
• W2171637756 hasConcept C523546767 @default.
• W2171637756 hasConcept C535046627 @default.

• next