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• W2171662092 abstract "Viral protein R (Vpr) encoded by HIV-1 is a facultative inducer of apoptosis. When added to intact cells or purified mitochondria, micromolar and submicromolar doses of synthetic Vpr cause a rapid dissipation of the mitochondrial transmembrane potential (ΔΨm), as well as the mitochondrial release of apoptogenic proteins such as cytochrome c or apoptosis inducing factor. The same structural motifs relevant for cell killing are responsible for the mitochondriotoxic effects of Vpr. Both mitochondrial and cytotoxic Vpr effects are prevented by Bcl-2, an inhibitor of the permeability transition pore complex (PTPC). Coincubation of purified organelles revealed that nuclear apoptosis is only induced by Vpr when mitochondria are present yet can be abolished by PTPC inhibitors. Vpr favors the permeabilization of artificial membranes containing the purified PTPC or defined PTPC components such as the adenine nucleotide translocator (ANT) combined with Bax. Again, this effect is prevented by addition of recombinant Bcl-2. The Vpr COOH terminus binds purified ANT, as well as a molecular complex containing ANT and the voltage-dependent anion channel (VDAC), another PTPC component. Yeast strains lacking ANT or VDAC are less susceptible to Vpr-induced killing than control cells yet recover Vpr sensitivity when retransfected with yeast ANT or human VDAC. Hence, Vpr induces apoptosis via a direct effect on the mitochondrial PTPC." @default.
• W2171662092 created "2016-06-24" @default.
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• W2171662092 date "2000-01-03" @default.
• W2171662092 modified "2023-10-12" @default.
• W2171662092 title "The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore" @default.
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• W2171662092 cites W1575666495 @default.
• W2171662092 cites W1633538413 @default.
• W2171662092 cites W1658514113 @default.
• W2171662092 cites W1823160263 @default.
• W2171662092 cites W1843376861 @default.
• W2171662092 cites W1845459216 @default.
• W2171662092 cites W1919819709 @default.
• W2171662092 cites W1961313548 @default.
• W2171662092 cites W1979129905 @default.
• W2171662092 cites W1981483033 @default.
• W2171662092 cites W1982687089 @default.
• W2171662092 cites W1985903968 @default.
• W2171662092 cites W1989819854 @default.
• W2171662092 cites W1991947087 @default.
• W2171662092 cites W1998175560 @default.
• W2171662092 cites W2003868334 @default.
• W2171662092 cites W2005430818 @default.
• W2171662092 cites W2006409246 @default.
• W2171662092 cites W2007150582 @default.
• W2171662092 cites W2008757391 @default.
• W2171662092 cites W2012173926 @default.
• W2171662092 cites W2013004567 @default.
• W2171662092 cites W2013319326 @default.
• W2171662092 cites W2020321505 @default.
• W2171662092 cites W2022883845 @default.
• W2171662092 cites W2027214164 @default.
• W2171662092 cites W2032119196 @default.
• W2171662092 cites W2035799757 @default.
• W2171662092 cites W2038055601 @default.
• W2171662092 cites W2043631238 @default.
• W2171662092 cites W2046104345 @default.
• W2171662092 cites W2049938816 @default.
• W2171662092 cites W2049958866 @default.
• W2171662092 cites W2070497052 @default.
• W2171662092 cites W2074634235 @default.
• W2171662092 cites W2075749235 @default.
• W2171662092 cites W2087480936 @default.
• W2171662092 cites W2089135460 @default.
• W2171662092 cites W2091613514 @default.
• W2171662092 cites W2099644089 @default.
• W2171662092 cites W2099782613 @default.
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• W2171662092 cites W2108131089 @default.
• W2171662092 cites W2108779766 @default.
• W2171662092 cites W2110357545 @default.
• W2171662092 cites W2116014786 @default.
• W2171662092 cites W2130866079 @default.
• W2171662092 cites W2142301272 @default.
• W2171662092 cites W2147357406 @default.
• W2171662092 cites W2149321851 @default.
• W2171662092 cites W2149967205 @default.
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• W2171662092 doi "https://doi.org/10.1084/jem.191.1.33" @default.
• W2171662092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2195797" @default.
• W2171662092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10620603" @default.
• W2171662092 hasPublicationYear "2000" @default.
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