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• W2171662488 abstract "The genomic architecture of African populations is poorly understood and there is considerable variation between ethno‐linguistic groups. Genome‐wide approaches have been extensively applied to search for genetic associations to complex traits in Europeans, but rarely in Africans. This is largely attributed to lower levels of funding, poor infrastructure and public health systems, and to the small pool of trained scientists. High levels of genetic variation and underlying population structure in Africans present significant challenges, but lower levels of linkage disequilibrium provide an opportunity for more effective localisation of causal variants. High throughput technologies, including dense genotyping arrays, genome sequencing and epigenome studies, together with plummeting costs, are making research more affordable, even for African scientists. Understanding the interactions between genome structure and environmental influences is essential to interpreting their contributions to the increase in infectious diseases and non‐communicable diseases, exacerbated by adverse environments and lifestyle choices. The unique genome dynamics in African populations have an important role to play in understanding human health and susceptibility to disease." @default.
• W2171662488 created "2016-06-24" @default.
• W2171662488 creator A5055162088 @default.
• W2171662488 date "2012-07-30" @default.
• W2171662488 modified "2023-10-18" @default.
• W2171662488 title "Africa: Continent of genome contrasts with implications for biomedical research and health" @default.
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• W2171662488 doi "https://doi.org/10.1016/j.febslet.2012.07.061" @default.
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