FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171695739> ?p ?o ?g. }

• W2171695739 endingPage "1776" @default.
• W2171695739 startingPage "1768" @default.
• W2171695739 abstract "Secondary lymphedema is a debilitating condition, and genetic factors predisposing to its development remain largely unknown. Adrenomedullin (AM) is peptide encoded, together with proadrenomedullin N-terminal peptide (PAMP), by the Adm gene (adrenomedullin gene). AM and its putative receptor calcitonin receptor-like receptor (CLR) are implicated in angiogenesis and lymphangiogenesis during embryogenesis and wound healing, suggesting their possible involvement in secondary lymphedema. To investigate whether AM deficiency predisposes to secondary lymphedema, we used heterozygous adult mice with Adm gene-knockin stop mutation, which selectively abrogated AM, but preserved PAMP, expression (Adm(AM+/Δ) animals). After hind limb skin incision, Adm messenger RNA expression was upregulated in wounded tissue of both Adm(AM+/+) and Adm(AM+/Δ) mice. However, only Adm(AM+/Δ) animals developed limb swelling and histopathological lymphedematous changes, including epidermal thickening, elevated collagen fiber density, and increased microvessel diameter. Secondary lymphedema was prevented when circulating AM levels in Adm(AM+/Δ) mice were restored by systemic peptide delivery. In human skin, CLR was expressed in tissue components affected by lymphedema, including epidermis, lymphatics, and blood vessels. Our study identified a previously unrecognized role for endogenous AM as a key factor in secondary lymphedema pathogenesis and provided experimental in vivo evidence of an underlying germ-line genetic predisposition to developing this disorder." @default.
• W2171695739 created "2016-06-24" @default.
• W2171695739 creator A5003873270 @default.
• W2171695739 creator A5040445316 @default.
• W2171695739 creator A5046807661 @default.
• W2171695739 creator A5049300446 @default.
• W2171695739 creator A5058021116 @default.
• W2171695739 creator A5063288234 @default.
• W2171695739 creator A5070863308 @default.
• W2171695739 creator A5078637552 @default.
• W2171695739 creator A5080266991 @default.
• W2171695739 creator A5091106436 @default.
• W2171695739 date "2013-07-01" @default.
• W2171695739 modified "2023-10-13" @default.
• W2171695739 title "Adrenomedullin Haploinsufficiency Predisposes to Secondary Lymphedema" @default.
• W2171695739 cites W1965031747 @default.
• W2171695739 cites W1965549777 @default.
• W2171695739 cites W1969253200 @default.
• W2171695739 cites W1969937534 @default.
• W2171695739 cites W1971863163 @default.
• W2171695739 cites W1981492597 @default.
• W2171695739 cites W1988070199 @default.
• W2171695739 cites W1996150185 @default.
• W2171695739 cites W1997811287 @default.
• W2171695739 cites W2001266662 @default.
• W2171695739 cites W2005485699 @default.
• W2171695739 cites W2006642493 @default.
• W2171695739 cites W2009205588 @default.
• W2171695739 cites W2010972818 @default.
• W2171695739 cites W2011135163 @default.
• W2171695739 cites W2013355011 @default.
• W2171695739 cites W2013443224 @default.
• W2171695739 cites W2026385925 @default.
• W2171695739 cites W2030866439 @default.
• W2171695739 cites W2032124298 @default.
• W2171695739 cites W2037979222 @default.
• W2171695739 cites W2043008229 @default.
• W2171695739 cites W2045094761 @default.
• W2171695739 cites W2048136910 @default.
• W2171695739 cites W2048220093 @default.
• W2171695739 cites W2050183466 @default.
• W2171695739 cites W2051038958 @default.
• W2171695739 cites W2052734341 @default.
• W2171695739 cites W2054181778 @default.
• W2171695739 cites W2056366878 @default.
• W2171695739 cites W2075529341 @default.
• W2171695739 cites W2076183128 @default.
• W2171695739 cites W2092419989 @default.
• W2171695739 cites W2097838494 @default.
• W2171695739 cites W2099703857 @default.
• W2171695739 cites W2101605059 @default.
• W2171695739 cites W2102917831 @default.
• W2171695739 cites W2103137526 @default.
• W2171695739 cites W2105250564 @default.
• W2171695739 cites W2108828143 @default.
• W2171695739 cites W2111661868 @default.
• W2171695739 cites W2113750989 @default.
• W2171695739 cites W2123992393 @default.
• W2171695739 cites W2129889492 @default.
• W2171695739 cites W2134283594 @default.
• W2171695739 cites W2138019675 @default.
• W2171695739 cites W2152176577 @default.
• W2171695739 cites W2170062405 @default.
• W2171695739 cites W4231871328 @default.
• W2171695739 cites W4243748055 @default.
• W2171695739 doi "https://doi.org/10.1038/jid.2013.47" @default.
• W2171695739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3682392" @default.
• W2171695739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23364478" @default.
• W2171695739 hasPublicationYear "2013" @default.
• W2171695739 type Work @default.
• W2171695739 sameAs 2171695739 @default.
• W2171695739 citedByCount "20" @default.
• W2171695739 countsByYear W21716957392013 @default.
• W2171695739 countsByYear W21716957392014 @default.
• W2171695739 countsByYear W21716957392015 @default.
• W2171695739 countsByYear W21716957392016 @default.
• W2171695739 countsByYear W21716957392017 @default.
• W2171695739 countsByYear W21716957392019 @default.
• W2171695739 countsByYear W21716957392021 @default.
• W2171695739 countsByYear W21716957392022 @default.
• W2171695739 countsByYear W21716957392023 @default.
• W2171695739 crossrefType "journal-article" @default.
• W2171695739 hasAuthorship W2171695739A5003873270 @default.
• W2171695739 hasAuthorship W2171695739A5040445316 @default.
• W2171695739 hasAuthorship W2171695739A5046807661 @default.
• W2171695739 hasAuthorship W2171695739A5049300446 @default.
• W2171695739 hasAuthorship W2171695739A5058021116 @default.
• W2171695739 hasAuthorship W2171695739A5063288234 @default.
• W2171695739 hasAuthorship W2171695739A5070863308 @default.
• W2171695739 hasAuthorship W2171695739A5078637552 @default.
• W2171695739 hasAuthorship W2171695739A5080266991 @default.
• W2171695739 hasAuthorship W2171695739A5091106436 @default.
• W2171695739 hasBestOaLocation W21716957391 @default.
• W2171695739 hasConcept C104317684 @default.
• W2171695739 hasConcept C121608353 @default.
• W2171695739 hasConcept C126322002 @default.
• W2171695739 hasConcept C127716648 @default.
• W2171695739 hasConcept C134018914 @default.

• next