FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171696410> ?p ?o ?g. }

• W2171696410 endingPage "2486" @default.
• W2171696410 startingPage "2481" @default.
• W2171696410 abstract "Glutamine (Gln) and arginine (Arg) are conditionally essential amino acids with immunomodulatory properties. The aim of the study was to assess the effects of Gln and Arg alone or in combination on cytokine release by cultured colonic biopsies from patients with active Crohn's disease (CD). Ten consecutive patients [mean (range) age 26 (18-39) y] with active colonic CD (mean CD activity index: 383.7 +/- 129.8) were prospectively included in the study. Eight colonic biopsies were obtained via a colonoscopy and incubated during 18 h with low (physiological) or high (pharmacological) doses of Arg (0.1 or 2 mmol/L designated as Arg(low) or Arg(high), respectively) and Gln (0.6 or 10 mmol/L designated as Gln(low) or Gln(high), respectively). The concentrations of cytokines [interleukin (IL)-4, IL-10, IL-8, IL-6, tumor necrosis factor-alpha (TNFalpha), IL-1beta, interferon-gamma) were assessed by ELISA, and nitric oxide (NO) production was evaluated by Griess assay. Nuclear factor (NF)-kappaB p65 subunit, inhibitor of NFkappaB-alpha, and p38 mitogen-activated protein kinase (MAPK) were assessed by immunoblotting. Arg(high)/Gln(high) decreased the production of TNFalpha, IL-1beta, IL-8, and IL-6 (each P < 0.01). Arg(low)/Gln(high) decreased IL-6 and IL-8 production (both P < 0.01), whereas Arg(high)/Gln(low) did not affect cytokine and NO production. Arg(low)/Gln(high) and Arg(high)/Gln(high) decreased NF-kappaB p65 subunit expression, whereas p38 MAPK was decreased only by Arg(high)/Gln(high). Combined pharmacological doses of Arg and Gln decreased TNFalpha and the main proinflammatory cytokines release in active colonic CD biopsies via NF-kappaB and p38 MAPK pathways. These results could be the basis of prospective studies evaluating the effects of enteral supply of combined Arg and Gln during active CD." @default.
• W2171696410 created "2016-06-24" @default.
• W2171696410 creator A5011959066 @default.
• W2171696410 creator A5017285164 @default.
• W2171696410 creator A5023350135 @default.
• W2171696410 creator A5024120174 @default.
• W2171696410 creator A5034526107 @default.
• W2171696410 creator A5052704963 @default.
• W2171696410 creator A5065655219 @default.
• W2171696410 creator A5072898235 @default.
• W2171696410 creator A5073099637 @default.
• W2171696410 creator A5090970254 @default.
• W2171696410 date "2008-12-01" @default.
• W2171696410 modified "2023-10-11" @default.
• W2171696410 title "Combined Glutamine and Arginine Decrease Proinflammatory Cytokine Production by Biopsies from Crohn’s Patients in Association with Changes in Nuclear Factor-κB and p38 Mitogen-Activated Protein Kinase Pathways3" @default.
• W2171696410 cites W1524470153 @default.
• W2171696410 cites W1597142286 @default.
• W2171696410 cites W1896932421 @default.
• W2171696410 cites W1897551156 @default.
• W2171696410 cites W1901447316 @default.
• W2171696410 cites W1945745413 @default.
• W2171696410 cites W1966051238 @default.
• W2171696410 cites W1973661325 @default.
• W2171696410 cites W1976883702 @default.
• W2171696410 cites W1978512742 @default.
• W2171696410 cites W1986242902 @default.
• W2171696410 cites W1990615754 @default.
• W2171696410 cites W1995915603 @default.
• W2171696410 cites W1999855196 @default.
• W2171696410 cites W2002150254 @default.
• W2171696410 cites W2004925182 @default.
• W2171696410 cites W2005177957 @default.
• W2171696410 cites W2009964993 @default.
• W2171696410 cites W2037673353 @default.
• W2171696410 cites W2045274529 @default.
• W2171696410 cites W2048729604 @default.
• W2171696410 cites W2052683847 @default.
• W2171696410 cites W2053456880 @default.
• W2171696410 cites W2054172123 @default.
• W2171696410 cites W2063882975 @default.
• W2171696410 cites W2064393193 @default.
• W2171696410 cites W2069738824 @default.
• W2171696410 cites W2073409943 @default.
• W2171696410 cites W2075569471 @default.
• W2171696410 cites W2077511764 @default.
• W2171696410 cites W2085637472 @default.
• W2171696410 cites W2085641816 @default.
• W2171696410 cites W2089215754 @default.
• W2171696410 cites W2095164057 @default.
• W2171696410 cites W2107723500 @default.
• W2171696410 cites W2110214097 @default.
• W2171696410 cites W2127758731 @default.
• W2171696410 cites W2149085554 @default.
• W2171696410 cites W2155125073 @default.
• W2171696410 cites W2167415932 @default.
• W2171696410 cites W2171484002 @default.
• W2171696410 cites W2235485292 @default.
• W2171696410 cites W2419604885 @default.
• W2171696410 cites W2490211911 @default.
• W2171696410 cites W275343085 @default.
• W2171696410 cites W2952154786 @default.
• W2171696410 cites W4292198229 @default.
• W2171696410 cites W4376848734 @default.
• W2171696410 doi "https://doi.org/10.3945/jn.108.099127" @default.
• W2171696410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19022976" @default.
• W2171696410 hasPublicationYear "2008" @default.
• W2171696410 type Work @default.
• W2171696410 sameAs 2171696410 @default.
• W2171696410 citedByCount "75" @default.
• W2171696410 countsByYear W21716964102012 @default.
• W2171696410 countsByYear W21716964102013 @default.
• W2171696410 countsByYear W21716964102014 @default.
• W2171696410 countsByYear W21716964102015 @default.
• W2171696410 countsByYear W21716964102016 @default.
• W2171696410 countsByYear W21716964102017 @default.
• W2171696410 countsByYear W21716964102018 @default.
• W2171696410 countsByYear W21716964102019 @default.
• W2171696410 countsByYear W21716964102020 @default.
• W2171696410 countsByYear W21716964102021 @default.
• W2171696410 countsByYear W21716964102022 @default.
• W2171696410 countsByYear W21716964102023 @default.
• W2171696410 crossrefType "journal-article" @default.
• W2171696410 hasAuthorship W2171696410A5011959066 @default.
• W2171696410 hasAuthorship W2171696410A5017285164 @default.
• W2171696410 hasAuthorship W2171696410A5023350135 @default.
• W2171696410 hasAuthorship W2171696410A5024120174 @default.
• W2171696410 hasAuthorship W2171696410A5034526107 @default.
• W2171696410 hasAuthorship W2171696410A5052704963 @default.
• W2171696410 hasAuthorship W2171696410A5065655219 @default.
• W2171696410 hasAuthorship W2171696410A5072898235 @default.
• W2171696410 hasAuthorship W2171696410A5073099637 @default.
• W2171696410 hasAuthorship W2171696410A5090970254 @default.
• W2171696410 hasBestOaLocation W21716964101 @default.
• W2171696410 hasConcept C126322002 @default.
• W2171696410 hasConcept C134018914 @default.
• W2171696410 hasConcept C164027704 @default.
• W2171696410 hasConcept C17991360 @default.
• W2171696410 hasConcept C184235292 @default.

• next