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• W2171709731 startingPage "7445" @default.
• W2171709731 abstract "Abstract CD4+ T cell help is essential for primary CD8+ T cell responses to noninflammatory Ags. IL-2 is one of the principal cytokines made by naive CD4+ T cells, and we show in this study that it is an essential component of help. Adoptively transferred naive CD4+ TCR-transgenic OT-II cells supported endogenous primary CD8+ T cell responses, but IL-2-deficient OT-II cells were unable to provide help, although they responded to Ag in vivo and up-regulated CD40 ligand in vitro. Wild -type OT-II cells helped endogenous CD8+ T cell responses in IL-2-deficient mice, but not in IL-2Rα-deficient mice. Thus, CD4+ T cell-derived IL-2 is essential for CD8+ T cell responses to noninflammatory, cell-associated Ags. We suggest that it is also a critical component of help for CD8+ T cell responses to pathogens, because protective memory also requires CD8+ T cell stimulation by IL-2 during priming." @default.
• W2171709731 created "2016-06-24" @default.
• W2171709731 creator A5062496736 @default.
• W2171709731 creator A5074416895 @default.
• W2171709731 date "2008-12-01" @default.
• W2171709731 modified "2023-10-18" @default.
• W2171709731 title "Cutting Edge: CD4+ T Cell-Derived IL-2 Is Essential for Help-Dependent Primary CD8+ T Cell Responses" @default.
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• W2171709731 doi "https://doi.org/10.4049/jimmunol.181.11.7445" @default.
• W2171709731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19017930" @default.
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