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• W2171716457 endingPage "3134" @default.
• W2171716457 startingPage "3124" @default.
• W2171716457 abstract "The host response to viral infection involves the secretion of multiple cytokines which alter immune function and viral replication. These proteins activate several signal transduction pathways in infected cells which must be integrated to regulate cellular and viral gene expression. In this report, we demonstrate that specific transcription factors induced by distinct cytokines regulate HIV transcription by competitive binding to the p300 coactivator. Interferon-alpha (IFN-alpha) was found to inhibit NF-kappaB-dependent HIV gene expression stimulated by tumor necrosis factor-alpha (TNF-alpha). This inhibition was mediated by binding of the IFN-alpha signal transducer and activator of transcription 2, Stat2, to a specific domain of p300 which also binds to the RelA (p65) subunit of NF-kappaB. p300 was found to be limiting with respect to RelA (p65) and Stat2, and this effect was reversed by overexpression of p300. Inhibition by Stat2 was specific for NF-kappaB and was not mediated by Stat1, which is also induced by IFN-alpha. Gene activation induced by the Stat2 transcription domain was also inhibited by expression of RelA. These results demonstrate that HIV transcription can be regulated in the nucleus by competitive binding of specific cytokine-induced transcription factors to a discrete domain of a transcriptional coactivator." @default.
• W2171716457 created "2016-06-24" @default.
• W2171716457 creator A5038548969 @default.
• W2171716457 creator A5061211279 @default.
• W2171716457 creator A5069280887 @default.
• W2171716457 date "1998-06-01" @default.
• W2171716457 modified "2023-10-16" @default.
• W2171716457 title "Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300" @default.
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• W2171716457 doi "https://doi.org/10.1093/emboj/17.11.3124" @default.
• W2171716457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1170651" @default.
• W2171716457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9606194" @default.
• W2171716457 hasPublicationYear "1998" @default.
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