Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171722641> ?p ?o ?g. }
- W2171722641 endingPage "1466" @default.
- W2171722641 startingPage "1459" @default.
- W2171722641 abstract "Autophagy is an important mechanism used by macrophages to kill intracellular pathogens. The results reported in this study demonstrate that autophagy is also involved in the macrophage killing of the extracellular enteropathogen Citrobacter rodentium after phagocytosis. The process was significantly impaired in macrophages isolated from mice chronically infected with the helminth parasite Heligmosomoides polygyrus. The H. polygyrus-mediated inhibition of autophagy was Th2 dependent because it was not observed in macrophages isolated from helminth-infected STAT6-deficient mice. Moreover, autophagy of Citrobacter was inhibited by treating macrophages with IL-4 and IL-13. The effect of H. polygyrus on autophagy was associated with decreased expression and processing of L chain protein 3 (LC3), a key component of the autophagic machinery. The helminth-induced inhibition of LC3 expression and processing was STAT6 dependent and could be recapitulated by treatment of macrophages with IL-4 and IL-13. Knockdown of LC3 significantly inhibited autophagic killing of Citrobacter, attesting to the functional importance of the H. polygyrus-mediated downregulation of this process. These observations reveal a new aspect of the immunosuppressive effects of helminth infection and provide mechanistic insights into our earlier finding that H. polygyrus significantly worsens the in vivo course of Citrobacter infection." @default.
- W2171722641 created "2016-06-24" @default.
- W2171722641 creator A5002816827 @default.
- W2171722641 creator A5009580471 @default.
- W2171722641 creator A5023681698 @default.
- W2171722641 creator A5025812393 @default.
- W2171722641 creator A5028770057 @default.
- W2171722641 creator A5047903848 @default.
- W2171722641 creator A5051993838 @default.
- W2171722641 creator A5056408708 @default.
- W2171722641 creator A5071231661 @default.
- W2171722641 creator A5083908936 @default.
- W2171722641 date "2012-06-25" @default.
- W2171722641 modified "2023-10-14" @default.
- W2171722641 title "Helminth Infection Impairs Autophagy-Mediated Killing of Bacterial Enteropathogens by Macrophages" @default.
- W2171722641 cites W1774566179 @default.
- W2171722641 cites W1978751572 @default.
- W2171722641 cites W1989821468 @default.
- W2171722641 cites W1997236289 @default.
- W2171722641 cites W2003084688 @default.
- W2171722641 cites W2008833365 @default.
- W2171722641 cites W2012264087 @default.
- W2171722641 cites W2012451546 @default.
- W2171722641 cites W2014700733 @default.
- W2171722641 cites W2015141049 @default.
- W2171722641 cites W2019951158 @default.
- W2171722641 cites W2048705639 @default.
- W2171722641 cites W2049528479 @default.
- W2171722641 cites W2056628895 @default.
- W2171722641 cites W2060529168 @default.
- W2171722641 cites W2071928163 @default.
- W2171722641 cites W2073151343 @default.
- W2171722641 cites W2096745765 @default.
- W2171722641 cites W2096853390 @default.
- W2171722641 cites W2100403561 @default.
- W2171722641 cites W2100466458 @default.
- W2171722641 cites W2104161841 @default.
- W2171722641 cites W2106944985 @default.
- W2171722641 cites W2108205859 @default.
- W2171722641 cites W2110474686 @default.
- W2171722641 cites W2113697701 @default.
- W2171722641 cites W2114993203 @default.
- W2171722641 cites W2126766345 @default.
- W2171722641 cites W2131089732 @default.
- W2171722641 cites W2133235033 @default.
- W2171722641 cites W2133667312 @default.
- W2171722641 cites W2141165347 @default.
- W2171722641 cites W2147193342 @default.
- W2171722641 cites W2153685214 @default.
- W2171722641 cites W2164778558 @default.
- W2171722641 cites W2323322844 @default.
- W2171722641 cites W97697689 @default.
- W2171722641 doi "https://doi.org/10.4049/jimmunol.1200484" @default.
- W2171722641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3423331" @default.
- W2171722641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22732589" @default.
- W2171722641 hasPublicationYear "2012" @default.
- W2171722641 type Work @default.
- W2171722641 sameAs 2171722641 @default.
- W2171722641 citedByCount "38" @default.
- W2171722641 countsByYear W21717226412013 @default.
- W2171722641 countsByYear W21717226412014 @default.
- W2171722641 countsByYear W21717226412015 @default.
- W2171722641 countsByYear W21717226412016 @default.
- W2171722641 countsByYear W21717226412017 @default.
- W2171722641 countsByYear W21717226412018 @default.
- W2171722641 countsByYear W21717226412019 @default.
- W2171722641 countsByYear W21717226412020 @default.
- W2171722641 countsByYear W21717226412021 @default.
- W2171722641 countsByYear W21717226412022 @default.
- W2171722641 countsByYear W21717226412023 @default.
- W2171722641 crossrefType "journal-article" @default.
- W2171722641 hasAuthorship W2171722641A5002816827 @default.
- W2171722641 hasAuthorship W2171722641A5009580471 @default.
- W2171722641 hasAuthorship W2171722641A5023681698 @default.
- W2171722641 hasAuthorship W2171722641A5025812393 @default.
- W2171722641 hasAuthorship W2171722641A5028770057 @default.
- W2171722641 hasAuthorship W2171722641A5047903848 @default.
- W2171722641 hasAuthorship W2171722641A5051993838 @default.
- W2171722641 hasAuthorship W2171722641A5056408708 @default.
- W2171722641 hasAuthorship W2171722641A5071231661 @default.
- W2171722641 hasAuthorship W2171722641A5083908936 @default.
- W2171722641 hasBestOaLocation W21717226411 @default.
- W2171722641 hasConcept C104317684 @default.
- W2171722641 hasConcept C127561419 @default.
- W2171722641 hasConcept C190283241 @default.
- W2171722641 hasConcept C202751555 @default.
- W2171722641 hasConcept C203014093 @default.
- W2171722641 hasConcept C203522944 @default.
- W2171722641 hasConcept C2775945818 @default.
- W2171722641 hasConcept C2778885919 @default.
- W2171722641 hasConcept C2778910516 @default.
- W2171722641 hasConcept C2779244956 @default.
- W2171722641 hasConcept C2910319489 @default.
- W2171722641 hasConcept C547475151 @default.
- W2171722641 hasConcept C55493867 @default.
- W2171722641 hasConcept C86803240 @default.
- W2171722641 hasConcept C8891405 @default.
- W2171722641 hasConcept C89423630 @default.