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- W217172344 abstract "Abstract : Numbers dendritic cells (DCs) increased 100-fold in pancreata of mice with acute pancreatitis to account for nearly 15% of intrapancreatic leukocytes. Intrapancreatic DCs acquired a distinct immune phenotype in mice with acute pancreatitis; they expressed higher levels of major histocompatibility complex II and CD86 and increased production of interleukin-6, MCP 1, and TNFa. DC over-expansion exacerbated disease. However, DCs were also required for pancreatic viability; the exocrine pancreas died in mice that were depleted of DCs and challenged with caerulein or L-arginine. All mice with pancreatitis that were depleted of DCs died from acinar cell death within 4 days. These data suggest that DC have simultaneous paradoxical pro-inflammatory and protective effects in pancreatitis. Further investigations are warranted." @default.
- W217172344 created "2016-06-24" @default.
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- W217172344 date "2015-09-01" @default.
- W217172344 modified "2023-09-24" @default.
- W217172344 title "Divergent Effects of Dendritic Cells on Pancreatitis" @default.
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- W217172344 doi "https://doi.org/10.21236/ada624310" @default.
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