FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171723963> ?p ?o ?g. }

• W2171723963 endingPage "590" @default.
• W2171723963 startingPage "578" @default.
• W2171723963 abstract "The MukB–MukE–MukF protein complex is essential for chromosome condensation and segregation in Escherichia coli. The central component of this complex, the MukB protein, is related functionally and structurally to the ubiquitous SMC (structural maintenance of chromosomes) proteins. In a manner similar to SMC, MukB requires the association of two accessory proteins (MukE and MukF) for its function. MukF is a constitutive dimer that bridges the interaction between MukB and MukE. While MukB can condense DNA on its own, it requires MukF and MukE to ensure proper chromosome segregation. Here, we present a novel structure of the E. coli MukE–MukF complex, in which the intricate crystal packing interactions reveal an alternative MukE dimerization interface spanning both N- and C-terminal winged-helix domains of the protein. The structure also unveils additional cross-linking interactions between adjacent MukE–MukF complexes mediated by MukE. A variant of MukE encompassing point mutations on one of these surfaces does not affect assembly of the MukB–MukE–MukF complex and yet cannot restore the temperature sensitivity of the mukE∷kan strain, suggesting that this surface may mediate critical protein–protein interactions between MukB–MukE–MukF complexes. Since the dimerization interface of MukE overlaps with the region of the protein that interacts with MukB in the MukB–MukE–MukF complex, we suggest that competing MukB–MukE and MukE–MukE interactions may regulate the formation of higher-order structures of bacterial condensin." @default.
• W2171723963 created "2016-06-24" @default.
• W2171723963 creator A5008675765 @default.
• W2171723963 creator A5074374757 @default.
• W2171723963 creator A5088464399 @default.
• W2171723963 date "2011-09-01" @default.
• W2171723963 modified "2023-10-03" @default.
• W2171723963 title "The Role of MukE in Assembling a Functional MukBEF Complex" @default.
• W2171723963 cites W1493829949 @default.
• W2171723963 cites W1506664007 @default.
• W2171723963 cites W1539796472 @default.
• W2171723963 cites W1566530928 @default.
• W2171723963 cites W1783552201 @default.
• W2171723963 cites W1972979596 @default.
• W2171723963 cites W1975317507 @default.
• W2171723963 cites W1993324014 @default.
• W2171723963 cites W2021690339 @default.
• W2171723963 cites W2022073880 @default.
• W2171723963 cites W2025870609 @default.
• W2171723963 cites W2029687104 @default.
• W2171723963 cites W2032660941 @default.
• W2171723963 cites W2044014219 @default.
• W2171723963 cites W2046897395 @default.
• W2171723963 cites W2048988399 @default.
• W2171723963 cites W2058017150 @default.
• W2171723963 cites W2059634393 @default.
• W2171723963 cites W2062009657 @default.
• W2171723963 cites W2074986801 @default.
• W2171723963 cites W2081021926 @default.
• W2171723963 cites W2091470046 @default.
• W2171723963 cites W2091693645 @default.
• W2171723963 cites W2099626292 @default.
• W2171723963 cites W2101002332 @default.
• W2171723963 cites W2107554748 @default.
• W2171723963 cites W2113787496 @default.
• W2171723963 cites W2117177914 @default.
• W2171723963 cites W2132389538 @default.
• W2171723963 cites W2140918642 @default.
• W2171723963 cites W2143644703 @default.
• W2171723963 cites W2144081223 @default.
• W2171723963 cites W2153882574 @default.
• W2171723963 cites W2163341755 @default.
• W2171723963 doi "https://doi.org/10.1016/j.jmb.2011.08.009" @default.
• W2171723963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3482342" @default.
• W2171723963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21855551" @default.
• W2171723963 hasPublicationYear "2011" @default.
• W2171723963 type Work @default.
• W2171723963 sameAs 2171723963 @default.
• W2171723963 citedByCount "20" @default.
• W2171723963 countsByYear W21717239632012 @default.
• W2171723963 countsByYear W21717239632013 @default.
• W2171723963 countsByYear W21717239632014 @default.
• W2171723963 countsByYear W21717239632015 @default.
• W2171723963 countsByYear W21717239632017 @default.
• W2171723963 countsByYear W21717239632018 @default.
• W2171723963 countsByYear W21717239632019 @default.
• W2171723963 countsByYear W21717239632020 @default.
• W2171723963 countsByYear W21717239632021 @default.
• W2171723963 countsByYear W21717239632022 @default.
• W2171723963 countsByYear W21717239632023 @default.
• W2171723963 crossrefType "journal-article" @default.
• W2171723963 hasAuthorship W2171723963A5008675765 @default.
• W2171723963 hasAuthorship W2171723963A5074374757 @default.
• W2171723963 hasAuthorship W2171723963A5088464399 @default.
• W2171723963 hasBestOaLocation W21717239632 @default.
• W2171723963 hasConcept C104317684 @default.
• W2171723963 hasConcept C11804247 @default.
• W2171723963 hasConcept C12554922 @default.
• W2171723963 hasConcept C14036430 @default.
• W2171723963 hasConcept C155790170 @default.
• W2171723963 hasConcept C185592680 @default.
• W2171723963 hasConcept C2778354886 @default.
• W2171723963 hasConcept C30481170 @default.
• W2171723963 hasConcept C53645450 @default.
• W2171723963 hasConcept C54355233 @default.
• W2171723963 hasConcept C62478195 @default.
• W2171723963 hasConcept C86803240 @default.
• W2171723963 hasConcept C95444343 @default.
• W2171723963 hasConceptScore W2171723963C104317684 @default.
• W2171723963 hasConceptScore W2171723963C11804247 @default.
• W2171723963 hasConceptScore W2171723963C12554922 @default.
• W2171723963 hasConceptScore W2171723963C14036430 @default.
• W2171723963 hasConceptScore W2171723963C155790170 @default.
• W2171723963 hasConceptScore W2171723963C185592680 @default.
• W2171723963 hasConceptScore W2171723963C2778354886 @default.
• W2171723963 hasConceptScore W2171723963C30481170 @default.
• W2171723963 hasConceptScore W2171723963C53645450 @default.
• W2171723963 hasConceptScore W2171723963C54355233 @default.
• W2171723963 hasConceptScore W2171723963C62478195 @default.
• W2171723963 hasConceptScore W2171723963C86803240 @default.
• W2171723963 hasConceptScore W2171723963C95444343 @default.
• W2171723963 hasIssue "4" @default.
• W2171723963 hasLocation W21717239631 @default.
• W2171723963 hasLocation W21717239632 @default.
• W2171723963 hasLocation W21717239633 @default.
• W2171723963 hasLocation W21717239634 @default.
• W2171723963 hasOpenAccess W2171723963 @default.
• W2171723963 hasPrimaryLocation W21717239631 @default.

• next