FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171726487> ?p ?o ?g. }

• W2171726487 abstract "The 7-valent pneumococcal conjugate vaccine has been introduced in national immunisation programmes of most industrialised countries and recently in two African GAVI eligible countries (Rwanda and The Gambia). However the long term effects of PCV are still unclear, as beneficial direct and herd immunity effects might be countered by serotype replacement.A dynamic, age-structured, compartmental model of Streptococcus pneumoniae transmission was developed to predict the potential impact of PCV7 on the incidence of invasive disease accounting for both herd immunity and serotype replacement effects. The model was parameterised using epidemiological data from England and Wales and pre and post-vaccination surveillance data from the US.Model projections showed that serotype replacement plays a crucial role in determining the overall effect of a PCV7 vaccination programme and could reduce, negate or outweigh its beneficial impact. However, using the estimate of the competition parameter derived from the US post-vaccination experience, an infant vaccination programme would prevent 39,000 IPD cases in the 20 years after PCV7 introduction in the UK. Adding a catch-up campaign for under 2 or under 5 year olds would provide a further reduction of 1,200 or 3,300 IPD cases respectively, mostly in the first few years of the programme.This analysis suggests that a PCV vaccination programme would eradicate vaccine serotypes from circulation. However, the increase in carriage of non-vaccine serotypes, and the consequent increase in invasive disease, could reduce, negate or outweigh the benefit. These results are sensitive to changes in the protective effect of the vaccine, and, most importantly, to the level of competition between vaccine and non-vaccine types. The techniques developed here can be used to assess the introduction of vaccination programmes in developing countries and provide the basis for cost-effectiveness analyses." @default.
• W2171726487 created "2016-06-24" @default.
• W2171726487 creator A5008450204 @default.
• W2171726487 creator A5014566627 @default.
• W2171726487 creator A5054039682 @default.
• W2171726487 creator A5061900944 @default.
• W2171726487 creator A5077038458 @default.
• W2171726487 date "2010-04-08" @default.
• W2171726487 modified "2023-10-10" @default.
• W2171726487 title "Dynamic models of pneumococcal carriage and the impact of the Heptavalent Pneumococcal Conjugate Vaccine on invasive pneumococcal disease" @default.
• W2171726487 cites W1792758720 @default.
• W2171726487 cites W1865523903 @default.
• W2171726487 cites W1971935056 @default.
• W2171726487 cites W1984874957 @default.
• W2171726487 cites W1995090667 @default.
• W2171726487 cites W2000499723 @default.
• W2171726487 cites W2014639652 @default.
• W2171726487 cites W2014942315 @default.
• W2171726487 cites W2018407773 @default.
• W2171726487 cites W2018541880 @default.
• W2171726487 cites W2019294407 @default.
• W2171726487 cites W2023690749 @default.
• W2171726487 cites W2033992962 @default.
• W2171726487 cites W2039437872 @default.
• W2171726487 cites W2049386698 @default.
• W2171726487 cites W2056279541 @default.
• W2171726487 cites W2059608310 @default.
• W2171726487 cites W2060798023 @default.
• W2171726487 cites W2067301960 @default.
• W2171726487 cites W2068117377 @default.
• W2171726487 cites W2077913253 @default.
• W2171726487 cites W2084411853 @default.
• W2171726487 cites W2086203618 @default.
• W2171726487 cites W2094610210 @default.
• W2171726487 cites W2098218091 @default.
• W2171726487 cites W2098332275 @default.
• W2171726487 cites W2099759919 @default.
• W2171726487 cites W2105289911 @default.
• W2171726487 cites W2106710965 @default.
• W2171726487 cites W2108929426 @default.
• W2171726487 cites W2110780714 @default.
• W2171726487 cites W2111717771 @default.
• W2171726487 cites W2115116421 @default.
• W2171726487 cites W2116343700 @default.
• W2171726487 cites W2119422239 @default.
• W2171726487 cites W2121861720 @default.
• W2171726487 cites W2122598469 @default.
• W2171726487 cites W2128684438 @default.
• W2171726487 cites W2131411088 @default.
• W2171726487 cites W2131765138 @default.
• W2171726487 cites W2132149002 @default.
• W2171726487 cites W2135176459 @default.
• W2171726487 cites W2136061245 @default.
• W2171726487 cites W2138607660 @default.
• W2171726487 cites W2141461907 @default.
• W2171726487 cites W2142629602 @default.
• W2171726487 cites W2147768434 @default.
• W2171726487 cites W2153731590 @default.
• W2171726487 cites W2156158169 @default.
• W2171726487 cites W2156789991 @default.
• W2171726487 cites W2157809883 @default.
• W2171726487 cites W2157923998 @default.
• W2171726487 cites W2159301256 @default.
• W2171726487 cites W2159870543 @default.
• W2171726487 cites W2160636503 @default.
• W2171726487 cites W2160879811 @default.
• W2171726487 cites W2161944342 @default.
• W2171726487 cites W2162396363 @default.
• W2171726487 cites W2163480358 @default.
• W2171726487 cites W2167888974 @default.
• W2171726487 cites W2168059472 @default.
• W2171726487 cites W3025897641 @default.
• W2171726487 cites W4236032500 @default.
• W2171726487 cites W4237355411 @default.
• W2171726487 doi "https://doi.org/10.1186/1471-2334-10-90" @default.
• W2171726487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2867993" @default.
• W2171726487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20377886" @default.
• W2171726487 hasPublicationYear "2010" @default.
• W2171726487 type Work @default.
• W2171726487 sameAs 2171726487 @default.
• W2171726487 citedByCount "77" @default.
• W2171726487 countsByYear W21717264872012 @default.
• W2171726487 countsByYear W21717264872013 @default.
• W2171726487 countsByYear W21717264872014 @default.
• W2171726487 countsByYear W21717264872015 @default.
• W2171726487 countsByYear W21717264872016 @default.
• W2171726487 countsByYear W21717264872017 @default.
• W2171726487 countsByYear W21717264872018 @default.
• W2171726487 countsByYear W21717264872019 @default.
• W2171726487 countsByYear W21717264872020 @default.
• W2171726487 countsByYear W21717264872021 @default.
• W2171726487 countsByYear W21717264872023 @default.
• W2171726487 crossrefType "journal-article" @default.
• W2171726487 hasAuthorship W2171726487A5008450204 @default.
• W2171726487 hasAuthorship W2171726487A5014566627 @default.
• W2171726487 hasAuthorship W2171726487A5054039682 @default.
• W2171726487 hasAuthorship W2171726487A5061900944 @default.
• W2171726487 hasAuthorship W2171726487A5077038458 @default.
• W2171726487 hasBestOaLocation W21717264871 @default.
• W2171726487 hasConcept C10389963 @default.

• next