FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171763216> ?p ?o ?g. }

• W2171763216 endingPage "31" @default.
• W2171763216 startingPage "23" @default.
• W2171763216 abstract "Background : Miltefosine is a new drug of choice for the treatment of visceral leishmaniasis. Numerous experimental studies have shown miltefosine is effective on Leishmania donovani , however, effectiveness of miltefosine in treatment of L. infantum is not fully understood. The aims of the present study were to evaluate cytotoxic effects of miltefosine on Iranian strain of L. infantum , and to determine its 50% inhibitory concentration (IC50) as well as lethal dose. Methods : Anti-L. infantum activity of miltefosine was studied by treatment of cultured promastigotes with various concentration of miltefosine. MTT assay was used to determine L. infantum viability and the results were expressed as IC50. Annexin-V FLUOS staining was performed to study apoptotic properties of this drug by using FACS flow cytometry. Results : Miltefosine led to dose-dependent death of L. infantum with features compatible with apoptosis including cell shrinkage, DNA laddering, and externalization of phosphatidylserine with preservation of integrity of plasma membrane . The 100% effect was achieved at 22 µM and IC50 after 48 hours of incubation was 7 µM. Conclusion : Miltefosine exerts cytotoxic effect on Iranian strain of L. infantum via an apoptosis-related mechanism." @default.
• W2171763216 created "2016-06-24" @default.
• W2171763216 creator A5012391978 @default.
• W2171763216 creator A5024840030 @default.
• W2171763216 creator A5034814138 @default.
• W2171763216 creator A5047943073 @default.
• W2171763216 creator A5054955085 @default.
• W2171763216 creator A5062283041 @default.
• W2171763216 creator A5066283471 @default.
• W2171763216 creator A5090479270 @default.
• W2171763216 date "2009-01-01" @default.
• W2171763216 modified "2023-09-24" @default.
• W2171763216 title "Induction of Apoptosis by Miltefosine in Iranian Strain of Leishmania infantum Promastigotes" @default.
• W2171763216 cites W1965298389 @default.
• W2171763216 cites W1967939212 @default.
• W2171763216 cites W2020216656 @default.
• W2171763216 cites W2032352006 @default.
• W2171763216 cites W2034149848 @default.
• W2171763216 cites W2037063107 @default.
• W2171763216 cites W2037082550 @default.
• W2171763216 cites W2049815105 @default.
• W2171763216 cites W2066954635 @default.
• W2171763216 cites W2069913623 @default.
• W2171763216 cites W2074844168 @default.
• W2171763216 cites W2082350013 @default.
• W2171763216 cites W2082820997 @default.
• W2171763216 cites W2083885985 @default.
• W2171763216 cites W2088005735 @default.
• W2171763216 cites W2110577295 @default.
• W2171763216 cites W2119733059 @default.
• W2171763216 cites W2137600992 @default.
• W2171763216 cites W2142530823 @default.
• W2171763216 cites W2150604586 @default.
• W2171763216 cites W2152855843 @default.
• W2171763216 cites W2156382913 @default.
• W2171763216 cites W2170956456 @default.
• W2171763216 cites W2202673642 @default.
• W2171763216 cites W2286181004 @default.
• W2171763216 cites W2295599156 @default.
• W2171763216 cites W2333858943 @default.
• W2171763216 hasPublicationYear "2009" @default.
• W2171763216 type Work @default.
• W2171763216 sameAs 2171763216 @default.
• W2171763216 citedByCount "4" @default.
• W2171763216 countsByYear W21717632162017 @default.
• W2171763216 crossrefType "journal-article" @default.
• W2171763216 hasAuthorship W2171763216A5012391978 @default.
• W2171763216 hasAuthorship W2171763216A5024840030 @default.
• W2171763216 hasAuthorship W2171763216A5034814138 @default.
• W2171763216 hasAuthorship W2171763216A5047943073 @default.
• W2171763216 hasAuthorship W2171763216A5054955085 @default.
• W2171763216 hasAuthorship W2171763216A5062283041 @default.
• W2171763216 hasAuthorship W2171763216A5066283471 @default.
• W2171763216 hasAuthorship W2171763216A5090479270 @default.
• W2171763216 hasConcept C136764020 @default.
• W2171763216 hasConcept C185592680 @default.
• W2171763216 hasConcept C190283241 @default.
• W2171763216 hasConcept C202751555 @default.
• W2171763216 hasConcept C203014093 @default.
• W2171763216 hasConcept C2776555147 @default.
• W2171763216 hasConcept C2777752497 @default.
• W2171763216 hasConcept C2778689377 @default.
• W2171763216 hasConcept C2778918659 @default.
• W2171763216 hasConcept C2779637612 @default.
• W2171763216 hasConcept C2780783641 @default.
• W2171763216 hasConcept C2781092759 @default.
• W2171763216 hasConcept C2781257258 @default.
• W2171763216 hasConcept C2781417161 @default.
• W2171763216 hasConcept C41008148 @default.
• W2171763216 hasConcept C41625074 @default.
• W2171763216 hasConcept C55493867 @default.
• W2171763216 hasConcept C71928629 @default.
• W2171763216 hasConcept C86803240 @default.
• W2171763216 hasConcept C88634738 @default.
• W2171763216 hasConcept C98274493 @default.
• W2171763216 hasConceptScore W2171763216C136764020 @default.
• W2171763216 hasConceptScore W2171763216C185592680 @default.
• W2171763216 hasConceptScore W2171763216C190283241 @default.
• W2171763216 hasConceptScore W2171763216C202751555 @default.
• W2171763216 hasConceptScore W2171763216C203014093 @default.
• W2171763216 hasConceptScore W2171763216C2776555147 @default.
• W2171763216 hasConceptScore W2171763216C2777752497 @default.
• W2171763216 hasConceptScore W2171763216C2778689377 @default.
• W2171763216 hasConceptScore W2171763216C2778918659 @default.
• W2171763216 hasConceptScore W2171763216C2779637612 @default.
• W2171763216 hasConceptScore W2171763216C2780783641 @default.
• W2171763216 hasConceptScore W2171763216C2781092759 @default.
• W2171763216 hasConceptScore W2171763216C2781257258 @default.
• W2171763216 hasConceptScore W2171763216C2781417161 @default.
• W2171763216 hasConceptScore W2171763216C41008148 @default.
• W2171763216 hasConceptScore W2171763216C41625074 @default.
• W2171763216 hasConceptScore W2171763216C55493867 @default.
• W2171763216 hasConceptScore W2171763216C71928629 @default.
• W2171763216 hasConceptScore W2171763216C86803240 @default.
• W2171763216 hasConceptScore W2171763216C88634738 @default.
• W2171763216 hasConceptScore W2171763216C98274493 @default.
• W2171763216 hasIssue "2" @default.
• W2171763216 hasLocation W21717632161 @default.

• next