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• W2171769711 abstract "Psychopathy is a disorder that has typically been considered to result from a primary deficit in fear or empathy. Here the authors find that impulsive-antisocial psychopathic traits are correlated with hyper-reactivity of the dopaminergic reward system as measured with positron emission tomography and functional magnetic resonance imaging. Psychopathy is a personality disorder that is strongly linked to criminal behavior. Using [18F]fallypride positron emission tomography and blood oxygen level–dependent functional magnetic resonance imaging, we found that impulsive-antisocial psychopathic traits selectively predicted nucleus accumbens dopamine release and reward anticipation-related neural activity in response to pharmacological and monetary reinforcers, respectively. These findings suggest that neurochemical and neurophysiological hyper-reactivity of the dopaminergic reward system may comprise a neural substrate for impulsive-antisocial behavior and substance abuse in psychopathy." @default.
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• W2171769711 date "2010-03-14" @default.
• W2171769711 modified "2023-09-29" @default.
• W2171769711 title "Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits" @default.
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• W2171769711 doi "https://doi.org/10.1038/nn.2510" @default.
• W2171769711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2916168" @default.
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