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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171782904> ?p ?o ?g. }

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• W2171782904 abstract "ABSTRACT A single-cytosine-deletion in the herpes simplex virus gene encoding thymidine kinase (TK) was previously found in an acyclovir-resistant clinical isolate. A laboratory strain engineered to carry this mutation did not generate sufficient TK activity for detection by plaque autoradiography, which detected 0.25% wild-type activity. However, a drug sensitivity assay suggested that extremely low levels of TK are generated by this virus. The virus was estimated to express 0.09% of wild-type TK activity via a ribosomal frameshift 24 nucleotides upstream of the mutation. Remarkably, this appeared to be sufficient active TK to support a low level of reactivation from latently infected mouse trigeminal ganglia." @default.
• W2171782904 created "2016-06-24" @default.
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• W2171782904 date "2007-08-01" @default.
• W2171782904 modified "2023-10-10" @default.
• W2171782904 title "Expression of Extremely Low Levels of Thymidine Kinase from an Acyclovir-Resistant Herpes Simplex Virus Mutant Supports Reactivation from Latently Infected Mouse Trigeminal Ganglia" @default.
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• W2171782904 doi "https://doi.org/10.1128/jvi.00484-07" @default.
• W2171782904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1951311" @default.
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