FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171789898> ?p ?o ?g. }

• W2171789898 endingPage "231" @default.
• W2171789898 startingPage "226" @default.
• W2171789898 abstract "To determine the specificity of the previously demonstrated competition of verapamil with radioligand binding to alpha-adrenergic receptors, we examined the interaction of calcium channel blockers with alpha 1- and alpha 2-adrenergic receptors on several tissues. Verapamil competed for [3H] prazosin binding to alpha 1-adrenergic receptors and for [3H]yohimbine binding to alpha 2-adrenergic receptors in several tissues (human platelets, rat kidney and heart, and cultured muscle cells) with dissociation constants of 0.6-6 microM. The calcium channel blockers D600, D591, fendiline, and prenylamine--which are structural analogues of verapamil--also competed for [3H]yohimbine binding to human platelets. Two other calcium channel blockers, diltiazem and nifedipine, did not compete for [3H] yohimbine binding to human platelets or [3H]prazosin binding to membranes prepared from rat ventricles. We used [3H]nitrendipine binding to identify putative calcium channels on rat myocardial membranes. Nifedipine and verapamil blocked these [3H]nitrendipine-binding sites on ventricular membranes, but epinephrine and prazosin did not, indicating that the ventricular alpha 1 receptors and calcium channels are distinct. We found no specific [3H]nitrendipine binding to human platelets. We conclude that the interaction of verapamil with alpha-adrenergic receptors is not receptor subtype or tissue specific, that interaction with alpha-adrenergic receptors is not a property of all calcium channel blockers, and that the interaction of verapamil with alpha-adrenergic receptors and its interaction with calcium channels occur at at least two distinct sites." @default.
• W2171789898 created "2016-06-24" @default.
• W2171789898 creator A5030513190 @default.
• W2171789898 creator A5055677266 @default.
• W2171789898 creator A5057877905 @default.
• W2171789898 creator A5084951057 @default.
• W2171789898 date "1983-02-01" @default.
• W2171789898 modified "2023-10-15" @default.
• W2171789898 title "Interaction of verapamil and other calcium channel blockers with alpha 1- and alpha 2-adrenergic receptors." @default.
• W2171789898 cites W1550978342 @default.
• W2171789898 cites W1933466673 @default.
• W2171789898 cites W1967325029 @default.
• W2171789898 cites W1980460799 @default.
• W2171789898 cites W1991516364 @default.
• W2171789898 cites W1996361797 @default.
• W2171789898 cites W2002825170 @default.
• W2171789898 cites W2002935418 @default.
• W2171789898 cites W2027212330 @default.
• W2171789898 cites W2033349407 @default.
• W2171789898 cites W2036309159 @default.
• W2171789898 cites W2043813981 @default.
• W2171789898 cites W2049907486 @default.
• W2171789898 cites W2065958436 @default.
• W2171789898 cites W2071057568 @default.
• W2171789898 cites W2077768830 @default.
• W2171789898 cites W2080771434 @default.
• W2171789898 cites W2173520866 @default.
• W2171789898 cites W2337097677 @default.
• W2171789898 cites W2405336766 @default.
• W2171789898 cites W2405966273 @default.
• W2171789898 cites W2409804777 @default.
• W2171789898 cites W2412661964 @default.
• W2171789898 cites W2412948067 @default.
• W2171789898 doi "https://doi.org/10.1161/01.res.52.2.226" @default.
• W2171789898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6297831" @default.
• W2171789898 hasPublicationYear "1983" @default.
• W2171789898 type Work @default.
• W2171789898 sameAs 2171789898 @default.
• W2171789898 citedByCount "171" @default.
• W2171789898 countsByYear W21717898982012 @default.
• W2171789898 countsByYear W21717898982014 @default.
• W2171789898 countsByYear W21717898982015 @default.
• W2171789898 countsByYear W21717898982017 @default.
• W2171789898 countsByYear W21717898982020 @default.
• W2171789898 countsByYear W21717898982022 @default.
• W2171789898 countsByYear W21717898982023 @default.
• W2171789898 crossrefType "journal-article" @default.
• W2171789898 hasAuthorship W2171789898A5030513190 @default.
• W2171789898 hasAuthorship W2171789898A5055677266 @default.
• W2171789898 hasAuthorship W2171789898A5057877905 @default.
• W2171789898 hasAuthorship W2171789898A5084951057 @default.
• W2171789898 hasBestOaLocation W21717898981 @default.
• W2171789898 hasConcept C126322002 @default.
• W2171789898 hasConcept C134018914 @default.
• W2171789898 hasConcept C170493617 @default.
• W2171789898 hasConcept C185592680 @default.
• W2171789898 hasConcept C18699975 @default.
• W2171789898 hasConcept C2776741139 @default.
• W2171789898 hasConcept C2776885963 @default.
• W2171789898 hasConcept C2777022698 @default.
• W2171789898 hasConcept C2777676773 @default.
• W2171789898 hasConcept C2780548744 @default.
• W2171789898 hasConcept C2780648677 @default.
• W2171789898 hasConcept C40465926 @default.
• W2171789898 hasConcept C519063684 @default.
• W2171789898 hasConcept C55493867 @default.
• W2171789898 hasConcept C71924100 @default.
• W2171789898 hasConcept C85520022 @default.
• W2171789898 hasConcept C86803240 @default.
• W2171789898 hasConcept C98274493 @default.
• W2171789898 hasConceptScore W2171789898C126322002 @default.
• W2171789898 hasConceptScore W2171789898C134018914 @default.
• W2171789898 hasConceptScore W2171789898C170493617 @default.
• W2171789898 hasConceptScore W2171789898C185592680 @default.
• W2171789898 hasConceptScore W2171789898C18699975 @default.
• W2171789898 hasConceptScore W2171789898C2776741139 @default.
• W2171789898 hasConceptScore W2171789898C2776885963 @default.
• W2171789898 hasConceptScore W2171789898C2777022698 @default.
• W2171789898 hasConceptScore W2171789898C2777676773 @default.
• W2171789898 hasConceptScore W2171789898C2780548744 @default.
• W2171789898 hasConceptScore W2171789898C2780648677 @default.
• W2171789898 hasConceptScore W2171789898C40465926 @default.
• W2171789898 hasConceptScore W2171789898C519063684 @default.
• W2171789898 hasConceptScore W2171789898C55493867 @default.
• W2171789898 hasConceptScore W2171789898C71924100 @default.
• W2171789898 hasConceptScore W2171789898C85520022 @default.
• W2171789898 hasConceptScore W2171789898C86803240 @default.
• W2171789898 hasConceptScore W2171789898C98274493 @default.
• W2171789898 hasIssue "2" @default.
• W2171789898 hasLocation W21717898981 @default.
• W2171789898 hasLocation W21717898982 @default.
• W2171789898 hasOpenAccess W2171789898 @default.
• W2171789898 hasPrimaryLocation W21717898981 @default.
• W2171789898 hasRelatedWork W1487650343 @default.
• W2171789898 hasRelatedWork W1897175743 @default.
• W2171789898 hasRelatedWork W1963649833 @default.
• W2171789898 hasRelatedWork W2019826876 @default.
• W2171789898 hasRelatedWork W2066206614 @default.

• next