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• W2171805892 abstract "200-MHz scanning acoustic microscopy (SAM) and synchrotron radiation μCT (SR-μCT) were used to assess microstructural parameters, acoustic impedance Z and tissue degree of mineralization of bone (DMB) in site-matched regions of interest in femoral bone of two inbred strains. Transverse femoral sections taken from 5 C57BL/[email protected] (B6) and 5 C3H/[email protected] (C3H) mice (5.5 months old) were explored. Mass density ρ, elastic coefficient c11 and Young's modulus E1 were locally derived in the distal epiphysis, distal metaphysis for trabecular bone and mid-diaphysis for cortical bone using a rule-of-mixture model. Structural parameter estimations obtained from X-ray tomographic and acoustic images were almost identical. Both strains had the same bone diameter, but the C3H mice had greater cortical thickness and smaller cancellous diameter than did B6 mice. The average DMB and impedance values were in the range between 1.13 and 1.33 g cm− 3 and 5.8 and 7.8 Mrayl, respectively. All tissue parameters were lower in B6 mice than in C3H mice. However, interstrain differences of DMB were much less (up to 3.8%) than differences of Z (up to 13.2%). SAM and SR-μCT fulfill the requirement for a simultaneous evaluation of cortical bone microstructure and material properties at the tissue level. However, SAM provides a quantitative estimate of elastic properties at the tissue level that cannot be captured by SR-μCT. The strong differences in the measured acoustic impedances among the two inbred strains indicate that the impedance is a good parameter to detect genetic variations of the skeletal phenotype in small animal models." @default.
• W2171805892 created "2016-06-24" @default.
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• W2171805892 date "2007-12-01" @default.
• W2171805892 modified "2023-10-13" @default.
• W2171805892 title "Variations of microstructure, mineral density and tissue elasticity in B6/C3H mice" @default.
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• W2171805892 doi "https://doi.org/10.1016/j.bone.2007.08.042" @default.
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