Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171815237> ?p ?o ?g. }
- W2171815237 endingPage "90" @default.
- W2171815237 startingPage "79" @default.
- W2171815237 abstract "Substantial evidence collected from clinical data and experimental studies has indicated that CNS is not spared from diabetes complications. Impairments in CNS function are well documented in both type 1 and type 2 diabetic patients as well as in various animal models of diabetes, in terms of alterations in cognition, neuropsychology, neurobehavior, electrophysiology, structure, neurochemistry and apoptotic activities. These data suggest that primary diabetic encephalopathy exists as a definable diabetic complication. The mechanisms underlying this CNS complication are not clear. Experimental studies have suggested that neuronal apoptosis may play an important role in neuronal loss and impaired cognitive function. In diabetes multiple factors are responsible for neuronal apoptosis, such as a perturbed IGF system, hyperglycemia and the aging process itself. Recent data suggest that insulin/C-peptide deficiency may exert an eminent role. Administration of C-peptide partially corrects the perturbed IGF system in the brain and prevents neuronal apoptosis in hippocampus of type 1 diabetes. In neuroblastoma SH-SY5Y cells C-peptide provides a dose-dependent stimulation on cell proliferation and an anti-apoptotic effect as well. These studies provide a basis for administration of C-peptide as a potentially effective therapy for type 1 diabetes." @default.
- W2171815237 created "2016-06-24" @default.
- W2171815237 creator A5056437557 @default.
- W2171815237 creator A5077862962 @default.
- W2171815237 date "2004-01-01" @default.
- W2171815237 modified "2023-09-26" @default.
- W2171815237 title "C-peptide and Central Nervous System Complications in Diabetes" @default.
- W2171815237 cites W11052091 @default.
- W2171815237 cites W129984926 @default.
- W2171815237 cites W142505139 @default.
- W2171815237 cites W1479786696 @default.
- W2171815237 cites W1513089486 @default.
- W2171815237 cites W1566676785 @default.
- W2171815237 cites W176790561 @default.
- W2171815237 cites W189671908 @default.
- W2171815237 cites W1941856557 @default.
- W2171815237 cites W1964911695 @default.
- W2171815237 cites W1966215066 @default.
- W2171815237 cites W1967789041 @default.
- W2171815237 cites W1967829045 @default.
- W2171815237 cites W1968780567 @default.
- W2171815237 cites W1970102431 @default.
- W2171815237 cites W1970159422 @default.
- W2171815237 cites W1971708952 @default.
- W2171815237 cites W1973051283 @default.
- W2171815237 cites W1974588388 @default.
- W2171815237 cites W1977592390 @default.
- W2171815237 cites W1982045657 @default.
- W2171815237 cites W1982603788 @default.
- W2171815237 cites W1982794401 @default.
- W2171815237 cites W1984149465 @default.
- W2171815237 cites W1985219288 @default.
- W2171815237 cites W1985870422 @default.
- W2171815237 cites W1986228861 @default.
- W2171815237 cites W1988823437 @default.
- W2171815237 cites W1989244392 @default.
- W2171815237 cites W1990827407 @default.
- W2171815237 cites W1991865867 @default.
- W2171815237 cites W1991897193 @default.
- W2171815237 cites W1993179896 @default.
- W2171815237 cites W1998960746 @default.
- W2171815237 cites W1999351792 @default.
- W2171815237 cites W2001022831 @default.
- W2171815237 cites W2002521377 @default.
- W2171815237 cites W2003566202 @default.
- W2171815237 cites W2006184639 @default.
- W2171815237 cites W2007146531 @default.
- W2171815237 cites W2008563817 @default.
- W2171815237 cites W2008931703 @default.
- W2171815237 cites W2009726938 @default.
- W2171815237 cites W2010222033 @default.
- W2171815237 cites W2011539606 @default.
- W2171815237 cites W2012286557 @default.
- W2171815237 cites W2013949808 @default.
- W2171815237 cites W2014759828 @default.
- W2171815237 cites W2015157590 @default.
- W2171815237 cites W2015899437 @default.
- W2171815237 cites W2015903763 @default.
- W2171815237 cites W2018746320 @default.
- W2171815237 cites W2018803742 @default.
- W2171815237 cites W2019091647 @default.
- W2171815237 cites W2019561288 @default.
- W2171815237 cites W2022323467 @default.
- W2171815237 cites W2022741381 @default.
- W2171815237 cites W2025303448 @default.
- W2171815237 cites W2027417024 @default.
- W2171815237 cites W2028634634 @default.
- W2171815237 cites W2029479814 @default.
- W2171815237 cites W2029793355 @default.
- W2171815237 cites W2030893161 @default.
- W2171815237 cites W2031961864 @default.
- W2171815237 cites W2033003442 @default.
- W2171815237 cites W2034929109 @default.
- W2171815237 cites W2035695710 @default.
- W2171815237 cites W2036284058 @default.
- W2171815237 cites W2038453644 @default.
- W2171815237 cites W2039404300 @default.
- W2171815237 cites W2040948638 @default.
- W2171815237 cites W2042188765 @default.
- W2171815237 cites W2042222492 @default.
- W2171815237 cites W2042877410 @default.
- W2171815237 cites W2043626970 @default.
- W2171815237 cites W2049207423 @default.
- W2171815237 cites W2050640530 @default.
- W2171815237 cites W2051455962 @default.
- W2171815237 cites W2052369986 @default.
- W2171815237 cites W2053147791 @default.
- W2171815237 cites W2053623116 @default.
- W2171815237 cites W2054543840 @default.
- W2171815237 cites W2056027814 @default.
- W2171815237 cites W2057042201 @default.
- W2171815237 cites W2057043467 @default.
- W2171815237 cites W2057262715 @default.
- W2171815237 cites W2060925403 @default.
- W2171815237 cites W2061301012 @default.
- W2171815237 cites W2063510032 @default.
- W2171815237 cites W2066584241 @default.
- W2171815237 cites W2068187395 @default.