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- W2171818152 abstract "Significance Alzheimer’s disease (AD) is a devastating disease that results in the progressive cognitive deficits of elderly and has become one of major social and economic burdens worldwide. There is no effective drug or therapy to prevent or halt the progressive cognitive dysfunctions due to the complex mechanisms such as accumulation of amyloid-β (Aβ), increase in oxidative stress, and formation of neurofibrillary tangle that drive the development of the disease. We found here that Edaravone, a drug that has been used for ischemic stroke, is able to prevent and treat AD by targeting multiple pathways of AD pathogenesis and rescuing the cognitive deficits of a mouse model of AD. Our study suggests Edaravone is a promising drug candidate for AD." @default.
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- W2171818152 date "2015-04-06" @default.
- W2171818152 modified "2023-10-16" @default.
- W2171818152 title "Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits" @default.
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- W2171818152 doi "https://doi.org/10.1073/pnas.1422998112" @default.
- W2171818152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4413288" @default.
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