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- W2171831719 abstract "Abstract Disease relapse is a barrier to achieving therapeutic success after unrelated umbilical cord-blood transplantation (UCBT) for B-lineage acute lymphoblastic leukemia (B-ALL). While adoptive transfer of donor-derived tumor-specific T cells is a conceptually attractive approach to eliminating residual disease after allogeneic hematopoietic stem cell transplantation, adoptive immunotherapy after UCBT is constrained by the difficulty of generating antigen-specific T cells from functionally naive umbilical cord-blood (UCB)–derived T cells. Therefore, to generate T cells that recognize B-ALL, we have developed a chimeric immunoreceptor to redirect the specificity of T cells for CD19, a B-lineage antigen, and expressed this transgene in UCB-derived T cells. An ex vivo process, which is compliant with current good manufacturing practice for T-cell trials, has been developed to genetically modify and numerically expand UCB-derived T cells into CD19-specific effector cells. These are capable of CD19-restricted cytokine production and cytolysis in vitro, as well as mediating regression of CD19+ tumor and being selectively eliminated in vivo. Moreover, time-lapse microscopy of the genetically modified T-cell clones revealed an ability to lyse CD19+ tumor cells specifically and repetitively. These data provide the rationale for infusing UCB-derived CD19-specific T cells after UCBT to reduce the incidence of CD19+ B-ALL relapse." @default.
- W2171831719 created "2016-06-24" @default.
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- W2171831719 date "2006-04-01" @default.
- W2171831719 modified "2023-09-27" @default.
- W2171831719 title "Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy" @default.
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- W2171831719 doi "https://doi.org/10.1182/blood-2005-09-3904" @default.
- W2171831719 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1895371" @default.
- W2171831719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16352804" @default.
- W2171831719 hasPublicationYear "2006" @default.
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