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- W2171832017 endingPage "2095" @default.
- W2171832017 startingPage "2081" @default.
- W2171832017 abstract "Objective: We used the contingent negative variation (CNV), a slow negative shift in the human electroencephalogram, to investigate the effects of heavy chronic alcohol use on frontal lobe function. Methods: Event-related potentials (ERPs) were recorded from 30 heavy drinkers (HD) and 30 age-, sex-, and education-matched light or non-drinkers (LD), using a classical two-stimulus reaction time (RT) paradigm. Structural magnetic resonance images and neuropsychological tests were also administered. Results: The amplitude of the late CNV was significantly reduced in HD relative to light drinkers. Moreover, diminished CNV amplitudes in HD appear to be closely related to the amount of recent alcohol consumption. There were no significant differences in neuropsychological measures of frontal lobe function and frontal lobe volume between light and HD. However, in HD, reduced late CNV amplitudes were associated with decreased frontal lobe gray matter volume and poor performance on the Trail Making Test B. In LD but not in HD, late CNV amplitude correlated positively with RT, suggesting that the late CNV reflects some aspect of motor and cognitive preparation. Conclusions: The inverse relationships between frontal lobe gray matter volume, performance on the Trail Making Test B, and late CNV amplitude in HD suggest that the ERP abnormalities observed in the current study may be indices of alcohol-related damage to the frontal lobe. The lack of a significant relationship between CNV amplitude and RT in HD suggests that chronic heavy alcohol use may disrupt response preparation." @default.
- W2171832017 created "2016-06-24" @default.
- W2171832017 creator A5016655815 @default.
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- W2171832017 creator A5030259393 @default.
- W2171832017 creator A5043086041 @default.
- W2171832017 creator A5077461136 @default.
- W2171832017 date "2003-11-01" @default.
- W2171832017 modified "2023-10-16" @default.
- W2171832017 title "Abnormal CNV in chronic heavy drinkers" @default.
- W2171832017 cites W1532002900 @default.
- W2171832017 cites W1564954331 @default.
- W2171832017 cites W1717237246 @default.
- W2171832017 cites W1747187494 @default.
- W2171832017 cites W1964593594 @default.
- W2171832017 cites W1966719574 @default.
- W2171832017 cites W1967064690 @default.
- W2171832017 cites W1967570549 @default.
- W2171832017 cites W1970134745 @default.
- W2171832017 cites W1973020649 @default.
- W2171832017 cites W1975111110 @default.
- W2171832017 cites W1975891687 @default.
- W2171832017 cites W1976658908 @default.
- W2171832017 cites W1977647122 @default.
- W2171832017 cites W1980275523 @default.
- W2171832017 cites W1980955999 @default.
- W2171832017 cites W1983370377 @default.
- W2171832017 cites W1983865092 @default.
- W2171832017 cites W1984714084 @default.
- W2171832017 cites W1985406757 @default.
- W2171832017 cites W1986152450 @default.
- W2171832017 cites W1988137020 @default.
- W2171832017 cites W1991518315 @default.
- W2171832017 cites W1993882156 @default.
- W2171832017 cites W1997992117 @default.
- W2171832017 cites W1998263462 @default.
- W2171832017 cites W1999287710 @default.
- W2171832017 cites W2002247919 @default.
- W2171832017 cites W2003193193 @default.
- W2171832017 cites W2003555002 @default.
- W2171832017 cites W2005355876 @default.
- W2171832017 cites W2007315806 @default.
- W2171832017 cites W2010074472 @default.
- W2171832017 cites W2012532506 @default.
- W2171832017 cites W2013986699 @default.
- W2171832017 cites W2020702328 @default.
- W2171832017 cites W2021288198 @default.
- W2171832017 cites W2025509949 @default.
- W2171832017 cites W2028174874 @default.
- W2171832017 cites W2029182909 @default.
- W2171832017 cites W2033115610 @default.
- W2171832017 cites W2034715896 @default.
- W2171832017 cites W2035826919 @default.
- W2171832017 cites W2037140536 @default.
- W2171832017 cites W2039991528 @default.
- W2171832017 cites W2042546599 @default.
- W2171832017 cites W2044059679 @default.
- W2171832017 cites W2045538625 @default.
- W2171832017 cites W2046099486 @default.
- W2171832017 cites W2050687083 @default.
- W2171832017 cites W2053694359 @default.
- W2171832017 cites W2054986991 @default.
- W2171832017 cites W2060225459 @default.
- W2171832017 cites W2060952523 @default.
- W2171832017 cites W2063745998 @default.
- W2171832017 cites W2066343009 @default.
- W2171832017 cites W2067495470 @default.
- W2171832017 cites W2067606046 @default.
- W2171832017 cites W2071243708 @default.
- W2171832017 cites W2071911502 @default.
- W2171832017 cites W2076950966 @default.
- W2171832017 cites W2077298558 @default.
- W2171832017 cites W2077751480 @default.
- W2171832017 cites W2077947740 @default.
- W2171832017 cites W2078351862 @default.
- W2171832017 cites W2079450587 @default.
- W2171832017 cites W2082037206 @default.
- W2171832017 cites W2082105944 @default.
- W2171832017 cites W2085014172 @default.
- W2171832017 cites W2087528167 @default.
- W2171832017 cites W2088410872 @default.
- W2171832017 cites W2099071282 @default.
- W2171832017 cites W2104285522 @default.
- W2171832017 cites W2106761770 @default.
- W2171832017 cites W2108806570 @default.
- W2171832017 cites W2109208595 @default.
- W2171832017 cites W2109886793 @default.
- W2171832017 cites W2113224712 @default.
- W2171832017 cites W2119848633 @default.
- W2171832017 cites W2120357670 @default.
- W2171832017 cites W2121477985 @default.
- W2171832017 cites W2121904084 @default.
- W2171832017 cites W2122418275 @default.
- W2171832017 cites W2125504089 @default.
- W2171832017 cites W2130686832 @default.
- W2171832017 cites W2135148619 @default.
- W2171832017 cites W2136273577 @default.
- W2171832017 cites W2136851296 @default.